Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis
| العنوان: | Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis |
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| المؤلفون: | Georg A. Böhmig, Morton J. Cowan, Nicolaas Schaap, Cyril Garrouste, E.M. Dauber, Søren Schwartz Sørensen, Michael Eder, Michael Kammer, Hideki Ishida, Anette Bachmann, Ulrich A. Duffner, Christoph Schwarz, Gabriela A. Berlakovich, Tepsiri Chongkrairatanakul, Sergio Alvarez, Thomas Wekerle, Rommel Ravanan, Niels Jacobsen, Michael Medinger, Heinz Regele, Martina Koch, Rainer Oberbauer, Robert S. Gaston, Brett Cullis, Masouridi Levrat Stavroula |
| المصدر: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 19, iss 2 American Journal of Transplantation Eder, M, Schwarz, C, Kammer, M, Jacobsen, N, Stavroula, M L, Cowan, M J, Chongkrairatanakul, T, Gaston, R, Ravanan, R, Ishida, H, Bachmann, A, Alvarez, S, Koch, M, Garrouste, C, Duffner, U A, Cullis, B, Schaap, N, Medinger, M, Sørensen, S S, Dauber, E-M, Böhmig, G, Regele, H, Berlakovich, G A, Wekerle, T & Oberbauer, R 2019, ' Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis ', American Journal of Transplantation, vol. 19, no. 2, pp. 475-487 . https://doi.org/10.1111/ajt.14970Test American Journal of Transplantation, 19, 475-487 American Journal of Transplantation, 19, 2, pp. 475-487 |
| بيانات النشر: | eScholarship, University of California, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Kidney Disease, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], medicine.medical_treatment, kidney transplantation/nephrology, tolerance: clinical, Hematopoietic stem cell transplantation, 030230 surgery, Regenerative Medicine, Medical and Health Sciences, Kidney Failure, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Living Donors, Immunology and Allergy, Pharmacology (medical), Chronic, Kidney transplantation, dysfunction, Graft Survival, Hematopoietic Stem Cell Transplantation, Immunosuppression, Clinical Science, Middle Aged, Prognosis, Allografts, Combined Modality Therapy, practice, Survival Rate, Tolerance induction, surgical procedures, operative, Original Article, 030211 gastroenterology & hepatology, Female, 6.4 Surgery, Immunosuppressive Agents, Homologous, Adult, medicine.medical_specialty, bone marrow, Adolescent, kidney (allograft) function, Renal and urogenital, Urology, nephrology, Renal function, kidney transplantation, kidney (allograft) function/dysfunction, clinical research/practice, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, medicine, Transplantation, Homologous, Humans, bone marrow/hematopoietic stem cell transplantation, Dialysis, Creatinine, Transplantation, business.industry, Evaluation of treatments and therapeutic interventions, Organ Transplantation, Stem Cell Research, medicine.disease, Kidney Transplantation, chemistry, clinical research, Case-Control Studies, Kidney Failure, Chronic, clinical [tolerance], Surgery, ORIGINAL ARTICLES, business, Follow-Up Studies |
| الوصف: | Tolerance induction through simultaneous hematopoietic stem cell and renal transplantation has shown promising results, but it is hampered by the toxicity of preconditioning therapies and graft‐versus‐host disease (GVHD). Moreover, renal function has never been compared to conventionally transplanted patients, thus, whether donor‐specific tolerance results in improved outcomes remains unanswered. We collected follow‐up data of published cases of renal transplantations after hematopoietic stem cell transplantation from the same donor and compared patient and transplant kidney survival as well as function with caliper‐matched living‐donor renal transplantations from the Austrian dialysis and transplant registry. Overall, 22 tolerant and 20 control patients were included (median observation period 10 years [range 11 months to 26 years]). In the tolerant group, no renal allograft loss was reported, whereas 3 were lost in the control group. Median creatinine levels were 85 μmol/l (interquartile range [IQR] 72‐99) in the tolerant cohort and 118 μmol/l (IQR 99‐143) in the control group. Mixed linear‐model showed around 29% lower average creatinine levels throughout follow‐up in the tolerant group (P A long‐term follow‐up analysis shows stable renal graft function without immunosuppression and no graft loss in patients receiving renal transplantation after hematopoietic stem cell transplantation from the same donor. |
| وصف الملف: | application/pdf |
| تدمد: | 1600-6135 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dc32622bc53d90ab112f3590d70c0fTest https://escholarship.org/uc/item/0f16n45sTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e3dc32622bc53d90ab112f3590d70c0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16006135 |
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