نتائج البحث - "John S. Millar"

1

ApoC-III helical structure determines its ability to bind plasma lipoproteins and inhibit Lipoprotein Lipase-mediated triglyceride lipolysis

المؤلفون: Cecilia Vitali, Sumeet A. Khetarpal, Daniel J. Rader, John S. Millar, Sissel Lund-Katz, S. Walter Englander, Sylvia Stankov, Nicholas J. Hand, Michael C. Phillips, Leland Mayne

مصطلحات موضوعية: chemistry.chemical_classification, Very low-density lipoprotein, Lipoprotein lipase, Apolipoprotein B, biology, Triglyceride, Chemistry, Amino acid, chemistry.chemical_compound, Biochemistry, Helix, biology.protein, lipids (amino acids, peptides, and proteins), Alpha helix, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a500570d2f526eaf1ccbd1d3815d4b7cTest
https://doi.org/10.1101/2020.07.02.183178Test

2

Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins

المؤلفون: Michael G. Levin, Jeffrey T. Billheimer, John S. Millar, Sumeet A. Khetarpal, Joseph Park, Takashi Kuwano, Daniel J. Rader, Pradeep Natarajan, Derek Klarin, Cecilia Vitali, Papasani V. Subbaiah, Dhavamani Sugasini, Akhil Pampana

المصدر: PLoS Genetics, Vol 17, Iss 9, p e1009802 (2021)
PLoS Genetics

مصطلحات موضوعية: Endothelial lipase, Cancer Research, Hydrolases, QH426-470, Biochemistry, Fats, Mice, chemistry.chemical_compound, Medicine and Health Sciences, Lipases, Phospholipids, Genetics (clinical), chemistry.chemical_classification, Lipoprotein lipase, biology, Hydrolysis, Chemical Reactions, Postprandial Period, Lipids, Enzymes, Chemistry, Physical Sciences, lipids (amino acids, peptides, and proteins), Energy source, Research Article, Polyunsaturated fatty acid, medicine.medical_specialty, Lipolysis, Lipoproteins, Mutation, Missense, Diet, High-Fat, Internal medicine, Genetics, medicine, Animals, Humans, Lipase, Molecular Biology, Triglycerides, Ecology, Evolution, Behavior and Systematics, Nutrition, Triglyceride, Biology and Life Sciences, Proteins, Human Genetics, Diet, Endocrinology, chemistry, Liposomes, Enzymology, biology.protein, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af2e6182a90739aa574f13c5345882bTest
https://doi.org/10.1371/journal.pgen.1009802Test

3

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages—Brief Report

المؤلفون: Daniel J. Rader, Jeffrey T. Billheimer, Michael C. Phillips, Melanie A. Hachet, Muredach P. Reilly, Hongfeng Jiang, Babak Razani, Wenjun Li, Junichiro Tohyama, Jianting Shi, Robert C. Bauer, Hanrui Zhang, Chenyi Xue, John S. Millar

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 37:2156-2160

مصطلحات موضوعية: 0301 basic medicine, Time Factors, Genotype, Apolipoprotein B, Induced Pluripotent Stem Cells, Interleukin-1beta, Biology, Transfection, Gene Expression Regulation, Enzymologic, Article, 03 medical and health sciences, chemistry.chemical_compound, Sterol esterase, Humans, Chemokine CCL5, Gene Editing, chemistry.chemical_classification, Apolipoprotein A-I, Interleukin-6, Hydrolysis, Macrophages, Cell Differentiation, Hep G2 Cells, Sterol Esterase, Molecular biology, Lipoproteins, LDL, HEK293 Cells, Phenotype, 030104 developmental biology, Enzyme, ATP Binding Cassette Transporter 1, chemistry, Biochemistry, Gene Knockdown Techniques, ABCA1, Apolipoprotein B-100, Proteolysis, biology.protein, Cholesteryl ester, Cholesterol Esters, CRISPR-Cas Systems, Lysosomes, Cardiology and Cardiovascular Medicine, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e55c3c605b1e38c9b963a926dc5a5aTest
https://doi.org/10.1161/atvbaha.117.310023Test

4

Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis

المؤلفون: John S. Millar, Swapnil V. Shewale, Raymond N. Sequeira, Daniel J. Rader, Minal B. Mehta, Nicholas J. Hand

المصدر: Journal of Biological Chemistry. 292:10444-10454

مصطلحات موضوعية: Blood Glucose, 0301 basic medicine, medicine.medical_specialty, Phosphatase, Biology, Biochemistry, Gene Expression Regulation, Enzymologic, Energy homeostasis, Glycogen debranching enzyme, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein Phosphatase 1, Internal medicine, medicine, Animals, Glucose homeostasis, Glycogen synthase, Molecular Biology, Mice, Knockout, Glycogen, Gluconeogenesis, Fasting, Cell Biology, Metabolism, 030104 developmental biology, Endocrinology, Liver, chemistry, Organ Specificity, 030220 oncology & carcinogenesis, Glucose-6-Phosphatase, biology.protein, Phosphorylation, Energy Metabolism, Phosphoenolpyruvate carboxykinase, Phosphoenolpyruvate Carboxykinase (ATP)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c03904ce5327452d79306e2875e0ef3Test
https://doi.org/10.1074/jbc.m116.766329Test

5

Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E[S]

المصدر: Journal of Lipid Research, Vol 58, Iss 6, Pp 1214-1220 (2017)

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, medicine.medical_specialty, Very low-density lipoprotein, Statin, medicine.drug_class, Atorvastatin, cholesteryl ester transfer protein, QD415-436, 030204 cardiovascular system & hematology, Biochemistry, statins, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Anacetrapib, Internal medicine, Cholesterylester transfer protein, medicine, polycyclic compounds, lipoprotein metabolism, Triglyceride, biology, Chemistry, nutritional and metabolic diseases, Cell Biology, Metabolism, 3. Good health, drug therapy, 030104 developmental biology, kinetics, plasma lipid transfer proteins, biology.protein, lipids (amino acids, peptides, and proteins), medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab49cfcd207050f0bf4065fd06b15e2Test
http://www.sciencedirect.com/science/article/pii/S0022227520310130Test

6

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans

المصدر: Journal of Lipid Research, Vol 58, Iss 4, Pp 752-762 (2017)

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Agonist, Adolescent, medicine.drug_class, QD415-436, 030204 cardiovascular system & hematology, Biology, Pharmacology, Biochemistry, Feces, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, In vivo, medicine, Animals, Humans, Distribution (pharmacology), Macrophage, Liver X receptor, Research Articles, Aged, Liver X Receptors, Macrophages, Cholesterol, HDL, Reverse cholesterol transport, Biological Transport, Cell Biology, Mononuclear phagocyte system, Middle Aged, Atherosclerosis, lipoproteins, Cholesterol, 030104 developmental biology, Liver, chemistry, high density lipoprotein, Immunology, Cholesteryl ester, Nanoparticles, Female, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a62d8e481687a201a84014e01be9e8cTest
https://doi.org/10.1194/jlr.m075226Test

7

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

المؤلفون: William R. Lagor, Junichiro Tohyama, Daniel J. Rader, Tomoyuki Yasuda, Eleonora Cipollari, Xin Bi, Jeffrey T. Billheimer, John S. Millar, Hannah J Szapary, Takashi Kuwano, Nicholas N. Lyssenko

المصدر: Journal of Lipid Research, Vol 58, Iss 4, Pp 731-741 (2017)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, QD415-436, High-Density Lipoproteins, Pre-beta, 030204 cardiovascular system & hematology, Biochemistry, Excretion, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, In vivo, Internal medicine, Phospholipid transfer protein, medicine, Animals, Humans, Phospholipid Transfer Proteins, Research Articles, Sequence Deletion, phospholipid transfer protein activity, Cholesterol, Cholesterol, HDL, Reverse cholesterol transport, Biological Transport, Cell Biology, Metabolism, Dependovirus, high density lipoprotein/metabolism, animal models, macrophages, 030104 developmental biology, Gene Expression Regulation, Liver, chemistry, lipids (amino acids, peptides, and proteins), Efflux, ATP binding cassette transporter A1, atherosclerosis, Lipoproteins, HDL, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8b06193acd151667bb831e703d32c2Test
http://www.sciencedirect.com/science/article/pii/S0022227520338505Test

8

Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiationin vitro

المؤلفون: Micah Romer, Judith B. Grinspan, John S. Millar, Brigid K. Jensen, Sangwon F. Kim, Hubert Monnerie, Kelly L. Jordan-Sciutto

المصدر: Journal of Neurochemistry. 140:53-67

مصطلحات موضوعية: Male, 0301 basic medicine, Pyrrolidines, Cellular differentiation, digestive system, Biochemistry, Article, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Myelin, 0302 clinical medicine, polycyclic compounds, medicine, Animals, Transcription factor, Cells, Cultured, Sterol Regulatory Element Binding Proteins, biology, Serine Endopeptidases, Oligodendrocyte differentiation, food and beverages, Cell Differentiation, Lipid metabolism, Oligodendrocyte, Sterol regulatory element-binding protein, Myelin basic protein, Oligodendroglia, 030104 developmental biology, medicine.anatomical_structure, Animals, Newborn, biology.protein, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertases, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca8bb19756e3da3c613b84e0559c7dTest
https://doi.org/10.1111/jnc.13721Test

9

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

المؤلفون: Michael C. Phillips, Chad A. Mirkin, Daniel J. Rader, Duyen Quach, C. Shad Thaxton, Nicholas N. Lyssenko, Kasey C. Vickers, John S. Millar, Andrea J. Luthi, Kaylin M. McMahon

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 56, Iss 5, Pp 972-985 (2015)

مصطلحات موضوعية: ATP-binding cassette transporter G1, Cardiotonic Agents, Lipoproteins, Phospholipid, Drug Evaluation, Preclinical, QD415-436, ATP-binding cassette transporter A1, Coronary Artery Disease, 030204 cardiovascular system & hematology, Biology, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, High-density lipoprotein, Drug Stability, scavenger receptor class B type I, Cricetinae, Animals, Scavenger receptor, Research Articles, Phospholipids, 030304 developmental biology, ATP Binding Cassette Transporter, Subfamily G, Member 1, 0303 health sciences, Apolipoprotein A-I, Cholesterol, Macrophages, Molecular Mimicry, Biological Transport, Cell Biology, Scavenger Receptors, Class B, ATP Binding Cassette Transporter 1, chemistry, ABCG1, ABCA1, biology.protein, Nanoparticles, lipids (amino acids, peptides, and proteins), ATP-Binding Cassette Transporters, Efflux, Gold, atherosclerosis, cholesterol efflux

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0550abb1901911bc2d06d1f118adbb66Test
http://europepmc.org/articles/PMC4409287Test

10

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress

المؤلفون: Ali Javaheri, Evanthia E. Pashos, Edward E. Morrisey, Donna M. Conlon, Wenli Yang, Ying Liu, Jahangir Iqbal, Daniel J. Rader, Stephen A. Duncan, Xin Bi, John S. Millar, Robert A. Hegele, Marina Cuchel, Jianting Shi, Hailey I. Edelstein, Katherine J. Slovik, M. Mahmood Hussain

المصدر: Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein B, Induced Pluripotent Stem Cells, General Biochemistry, Genetics and Molecular Biology, Microsomal triglyceride transfer protein, Article, 03 medical and health sciences, apoB, Stress, Physiological, iPSC-derived hepatocytes and cardiomyocytes, medicine, Humans, Secretion, Myocytes, Cardiac, abetaliproteinemia, Induced pluripotent stem cell, lcsh:QH301-705.5, Apolipoproteins B, Gene Editing, ABL, biology, lipid accumulation, Abetalipoproteinemia, Lipid metabolism, medicine.disease, cardiac stress, Cell biology, 030104 developmental biology, Phenotype, lcsh:Biology (General), Biochemistry, biology.protein, Hepatocytes, lipids (amino acids, peptides, and proteins), Carrier Proteins, Intracellular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca22ad42cbd699b2109eefcd7e177f6dTest
https://pubmed.ncbi.nlm.nih.gov/28514664Test

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