Antioxidative/oxidative effects and retarding osteoconductivity of ciprofloxacin-loaded porous polyvinyl alcohol/bioactive glass hybrid
| العنوان: | Antioxidative/oxidative effects and retarding osteoconductivity of ciprofloxacin-loaded porous polyvinyl alcohol/bioactive glass hybrid |
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| المؤلفون: | Tarek Rebai, Hafed Elfeki, Khansa Chaabouni, Salha Boulila, Riadh Badraoui, Amany A. Mostafa, Hassane Oudadesse, Bertrand Lefeuvre, Fatma Makni-Ayedi, Mostafa Mabrouk, Allal Barroug, Abdelfattah Elfeki |
| المساهمون: | Faculté des Sciences de Sfax, Université de Sfax - University of Sfax, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Sfax Faculty of Medicine, National Research Centre - NRC (EGYPT), Université Cadi Ayyad [Marrakech] (UCA), Histology and Orthopaedic and Traumatology laboratory, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Medical and Biological Engineering and Computing Medical and Biological Engineering and Computing, Springer Verlag, 2017, 55 (1), pp.17-32. ⟨10.1007/s11517-016-1473-1⟩ Medical and Biological Engineering and Computing, 2017, 55 (1), pp.17-32. ⟨10.1007/s11517-016-1473-1⟩ |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Bone Regeneration, Antioxidant, medicine.medical_treatment, 02 engineering and technology, Antioxidants, Computer Applications, law.invention, chemistry.chemical_compound, Implants, Experimental, law, Ciprofloxacin, chemistry.chemical_classification, Tissue Scaffolds, biology, integumentary system, Glutathione peroxidase, Imaging / Radiology, Prooxidant, Melting, Catalase, 021001 nanoscience & nanotechnology, Malondialdehyde, 3. Good health, Computer Science Applications, Biochemistry, Bioactive glass, Ovariectomized rat, Alkaline phosphatase, Female, 0210 nano-technology, Porosity, Acid Phosphatase, Biomedical Engineering, Thiobarbituric Acid Reactive Substances, Bone and Bones, Superoxide dismutase, 03 medical and health sciences, medicine, Animals, [CHIM]Chemical Sciences, Rats, Wistar, Glutathione Peroxidase, Superoxide Dismutase, Spectrophotometry, Atomic, Acid phosphatase, Bioglass, Alkaline Phosphatase, Oxidative Stress, Retard, 030104 developmental biology, chemistry, Human Physiology, Polyvinyl Alcohol, Microscopy, Electron, Scanning, biology.protein, Glass, Nuclear chemistry |
| الوصف: | International audience; This study investigated the effect of bioglass (melting)-polyvinyl alcohol (BG (M)-PVA) and bioglass (melting)-polyvinyl alcohol-20 %ciprofloxacin (BG(M)-PVA-20Cip) in improving antioxidant activity and regenerating bone capacity. These composites were implanted in femoral condyles of ovariectomized Wistar rats and compared to that of controls groups. After the different period of implantation (15, 30, 60 and 90 days), the treatment of ovariectomized rats with BG(M)-PVA-20Cip showed a significantly higher malondialdehyde concentration when compared to that of BG(M)-PVA group. The superoxide dismutase, glutathione peroxidase and catalase in BG(M)-PVA-20Cip group showed significantly lower activities when compared to those in BG(M)-PVA group. So, BG(M)-PVA is more tolerated by organism than BG(M)-PVA-20Cip. Moreover, the alkaline phosphatase and acid phosphatase activities showed an excellent osteoinductive property of BG (M)-PVA. This property decreased with the presence of ciprofloxacin which is confirmed by histopathological analysis. Several physicochemical techniques showed a rapid reduction in Si and Na in one hand and an accelerator rise in Ca and P ions concentrations in other hand in BG(M)-PVA than in the BG(M)-PVA-20Cip. Therefore, the incorporation of ciprofloxacin in BG(M)-PVA is characterized by a prooxidant effect in oxidant–antioxidant balance at the beginning of treatment and a retard effect of formation of apatitic phase |
| اللغة: | English |
| تدمد: | 0140-0118 1741-0444 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce33e75e40b37f851bb8a8865606432Test https://hal-univ-rennes1.archives-ouvertes.fr/hal-01307769Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7ce33e75e40b37f851bb8a8865606432 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01400118 17410444 |
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