Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial
| العنوان: | Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial |
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| المؤلفون: | Celis-Morales, Carlos, Marsaux, Cyril F.M., Livingstone, Katherine M., Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Fallaize, Rosalind, Macready, Anna L., O’Donovan, Clarr, Woolhead, Clara, Forster, Hannah, Kolossa, Silvia, Daniel, Hannelore, Moschonis, George, Mavrogianni, Christina, Manios, Yannis, Surwillo, Agnieszka, Traczyk, Iwona, Drevon, Christian A., Grimaldi, Keith, Bouwman, Jildau, Gibney, Mike J., Walsh, Marianne C., Gibney, Eileen R., Brennan, Lorraine, Lovegrove, Julie A., Martinez, J. Alfredo, Saris, Wim H.M., Mathers, John C. |
| المساهمون: | Promovendi NTM, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - HB/BW section A, RS: NUTRIM - R1 - Metabolic Syndrome |
| المصدر: | American Journal of Clinical Nutrition, 105(5), 1204-1213. Oxford University Press American Journal of Clinical Nutrition, 5, 105, 1204-1213 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Health Knowledge, Attitudes, Practice, Adolescent, Genotype, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Biomedical Innovation, Genetic Counseling, Disclosure, Polymorphism, Single Nucleotide, Young Adult, Life, Risk Factors, Weight Loss, Humans, TECHNOLOGY, Genetic Predisposition to Disease, Obesity, INTERNET, Biology, Alleles, Adiposity, Body Weight, Personalized nutrition, ADULTS, Middle Aged, Weight, WEB, BODY-MASS INDEX, Europe, PHYSICAL-ACTIVITY, MSB - Microbiology and Systems Biology, Adipose Tissue, Randomized controlled trial, Female, ELSS - Earth, Life and Social Sciences, Waist Circumference, FTO, Healthy Living, INTERVENTIONS |
| الوصف: | Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesityrelated traits compared with the benefits of conventional one-size-fitsall advice. Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition. Design: A total of 683 participants (women: 51%; age range: 18'73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6. Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight andWC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm(-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)]. Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at clinicaltrials.gov as NCT01530139. © 2017 American Society for Nutrition. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0002-9165 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1309d35455ece94616bf7afa4a2567a8Test http://resolver.tudelft.nl/uuid:242226e5-f4f9-43bf-a534-cd473c07e2f6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....1309d35455ece94616bf7afa4a2567a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00029165 |
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