Pneumococcal Capsular Switching: A Historical Perspective
| العنوان: | Pneumococcal Capsular Switching: A Historical Perspective |
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| المؤلفون: | Wyres, KL, Lambertsen, LM, Croucher, NJ, McGee, L, Von Gottberg, A, Linares, J, Jacobs, MR, Kristinsson, KG, Beall, BW, Klugman, KP, Parkhill, J, Hakenbeck, R, Bentley, SD, Brueggemann, AB |
| المساهمون: | Medical Research Council (MRC) |
| المصدر: | The Journal of Infectious Diseases |
| بيانات النشر: | Oxford University Press, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Immunology, Molecular Sequence Data, STREPTOCOCCUS-PNEUMONIAE, UNITED-STATES, CHILDREN, Microbiology, EVOLUTIONARY GENETICS, INVASIVE-DISEASE, Evolution, Molecular, Major Articles and Brief Reports, CLONE, LOCUS, Humans, serotype, Serotyping, Capsule, Bacterial Capsules, Science & Technology, Bacteria, Base Sequence, HEAT-SHOCK, switching, 11 Medical And Health Sciences, 06 Biological Sciences, PNEUMONIAE SEROTYPE 14, Infectious Diseases, Streptococcus pneumoniae, Genes, Bacterial, Genetic Loci, Life Sciences & Biomedicine, CONJUGATE VACCINE, pneumococcus, Sequence Alignment, Multilocus Sequence Typing |
| الوصف: | Background . Changes in serotype prevalence among pneumococcal populations result from both serotype replacement and serotype (capsular) switching. Temporal changes in serotype distributions are well documented, but the contribution of capsular switching to such changes is unknown. Furthermore, it is unclear to what extent vaccine-induced selective pressures drive capsular switching. Methods . Serotype and multilocus sequence typing data for 426 pneumococci dated from 1937 through 2007 were analyzed. Whole-genome sequence data for a subset of isola tes were used to investigate capsular switching events. Results . We identi fi ed 36 independent capsular switch events, 18 of which were explored in detail with whole- genome sequence data. Recombination fragment lengths were estimated for 11 events and ranged from approximately 19.0 kb to ≥ 58.2 kb. Two events took place no later than 1960, and the imported DNA included the capsular locus and the nearby penicillin-binding protein genes pbp2x and pbp1a . Conclusions . Capsular switching has been a regular occurrence among pneumococcal populations throughout the past 7 decades. Recombination of large DNA fragments (>30 kb), sometimes including the capsular locus and penicil- lin-binding protein genes, predated both vaccine introducti on and widespread antibiotic use. This type of recombina- tion has likely been an intrinsic feature throughout the history of pneumococcal evolution. |
| اللغة: | English |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c7723a6216bc34c3ef29fa2ee728beaTest http://europepmc.org/articles/PMC3537446Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....3c7723a6216bc34c3ef29fa2ee728bea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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