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المؤلفون: U. Helena Danielson, Helena Nordström, Tom Dzus, Valeria Napolitano, Giulia Opassi, Gerhard Klebe, Arne Lundin, Francesca Magari
المصدر: Protein Science
Protein Science : A Publication of the Protein Societyمصطلحات موضوعية: Chagas disease, Thermal shift assay, Trypanosoma cruzi, Fragment-based lead discovery, Farnesyl pyrophosphate, SPR, Biochemistry, Pyrophosphate, Catalysis, Article, Cofactor, 03 medical and health sciences, chemistry.chemical_compound, Magnesium, Luciferase, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, 030302 biochemistry & molecular biology, Biochemistry and Molecular Biology, Geranyltranstransferase, fragment screening, Articles, Surface Plasmon Resonance, binding efficiency, biology.organism_classification, farnesyl pyrophosphate synthase, chemistry, biology.protein, Target protein, Biokemi och molekylärbiologi
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4244925221396853671363436167464eTest
https://doi.org/10.1002/pro.3834Test -
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المؤلفون: Grzegorz M Popowicz, Jos Buijs, Valeria Napolitano, Giulia Opassi, U. Helena Danielson, Hanna Björkelund, Grzegorz Dubin, João Crispim Encarnação, Hélène Munier-Lehmann, Karl Andersson
المساهمون: Ridgeview Instruments AB [Uppsala, Sueden], Department of Immunology, Genetics and Pathology [Uppsala, Sueden] (IGP), Uppsala University, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Department of Chemistry [Uppsala, Sueden], Biomedical Center = Biomedicinskt centrum [Uppsala, Sueden] (BMC), Uppsala University-Uppsala University, Malopolska Centre of Biotechnology [Krakow] (MCB), Helmholtz-Zentrum München (HZM), Center for Integrated Protein Science (CIPSM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Helmholtz-Zentrum München (HZM)-Ludwig Maximilian University of Munich [Germany] (LMU München), Chimie et Biocatalyse, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], This project has received funding from the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014–2020) under the Marie Sklodowska‐Curie Grant Agreement No. 675555, Accelerated Early staGe drug discovery (AEGIS)., Microscopic imaging was performed with equipment maintained by the BioVis Platform at Uppsala University. We thank to Dr Arie Geerlof and Dr André Mourão (Institute of Structural Biology, Helmholtz Zentrum München) for providing help on protein expression and purification of the STxB constructs., European Project: 675555,H2020,H2020-MSCA-ITN-2015,AEGIS(2016), Helmholtz Zentrum München = German Research Center for Environmental Health, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU)-Helmholtz Zentrum München = German Research Center for Environmental Health, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: FEBS Lett. 594, 2406-2420 (2020)
FEBS Letters
FEBS Letters, Wiley, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩
FEBS Letters, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩مصطلحات موضوعية: media_common.quotation_subject, [SDV]Life Sciences [q-bio], Cell, education, Biophysics, Globotriaosylceramide, cell surface receptor, Biological Transport, Active, Shiga Toxins, Biochemistry, real-time cell-binding assays, 03 medical and health sciences, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], Structural Biology, Cell surface receptor, receptor internalization, Neoplasms, Genetics, medicine, binding kinetics, cancer, Humans, Internalization, Molecular Biology, Binding Kinetics, Cancer, Cell Surface Receptor, Real-time Cell-binding Assays, Receptor Internalization, Shiga Toxin, real-time cell- binding assays, 030304 developmental biology, media_common, 0303 health sciences, Drug Carriers, Chemistry, Trihexosylceramides, 030302 biochemistry & molecular biology, Biochemistry and Molecular Biology, Cell Biology, Shiga toxin, Small molecule, Receptor–ligand kinetics, 3. Good health, Cell biology, ddc, medicine.anatomical_structure, Cancer cell, Biological Assay, K562 Cells, HT29 Cells, Intracellular, Biokemi och molekylärbiologi
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4182f413821e2c51a52d6f7a9bf9a7ffTest
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59243Test