المؤلفون: Chiara Borsari, Matthias P. Wymann, Martina De Pascale

المصدر: Chemmedchem

مصطلحات موضوعية: mTOR inhibitors, Structural similarity, Allosteric regulation, physicochemical properties, Blood–brain barrier, Biochemistry, binding modes, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, chemical scaffolds, Drug Discovery, medicine, BBB permeability, Humans, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, 030304 developmental biology, Pharmacology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, TOR Serine-Threonine Kinases, Organic Chemistry, Cancer, Minireviews, medicine.disease, Chemical space, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Molecular Medicine, Minireview

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610b11369182775aec800164fa18275dTest
https://doi.org/10.1002/cmdc.202100332Test

المؤلفون: Min Zhang, Han-Yue Qiu, Peng-Fei Wang

المصدر: Expert Opinion on Therapeutic Patents. 31:965-975

مصطلحات موضوعية: Cancer therapy, Antineoplastic Agents, 01 natural sciences, Patents as Topic, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Neoplasms, Drug Discovery, Animals, Humans, Medicine, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Pharmacology, Tumor biology, business.industry, Kinase, TOR Serine-Threonine Kinases, General Medicine, Discovery and development of mTOR inhibitors, 0104 chemical sciences, Cancer treatment, Atp competitive, 010404 medicinal & biomolecular chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f47ac51206b54f8c942d2fffa71b8b6Test
https://doi.org/10.1080/13543776.2021.1940137Test

المؤلفون: Li Li, Fang Wang, Yanling Jing, Chunjia Li, Lianmei Wang, Hongbing Yan, Caifeng Long, Kemei Liu, Aihua Liang, Xinyu Zhang, Yanan Wang, Hongbing Zhang, Yi Chen, Fangming Liu

المصدر: Journal of Cellular Physiology. 236:8110-8121

مصطلحات موضوعية: 0301 basic medicine, Physiology, Clinical Biochemistry, HSP27 Heat-Shock Proteins, Cardiomyopathy, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Gene expression, medicine, Animals, Myocytes, Cardiac, Promoter Regions, Genetic, Mechanistic target of rapamycin, Heat-Shock Proteins, PI3K/AKT/mTOR pathway, Mice, Knockout, Fetus, biology, TOR Serine-Threonine Kinases, Autophagy, MTOR Inhibitors, Cell Biology, medicine.disease, Crystallins, eye diseases, Cell biology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, biology.protein, sense organs, TSC1, Cardiomyopathies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f51fa4a71b1919dd5fcb02e157f5813Test
https://doi.org/10.1002/jcp.30465Test

المؤلفون: Nisreen Shamseddine, Namita Joshi, Xin Gao, Linlin Luo, Xingyue Huang

المصدر: Immunotherapy. 13:387-395

مصطلحات موضوعية: Adult, Male, endocrine system, medicine.medical_specialty, Immunology, Graft vs Host Disease, Disease, Medication Adherence, Time-to-Treatment, Insurance Claim Review, 03 medical and health sciences, Continuation, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, Outcome Assessment, Health Care, Extracorporeal Photopheresis, medicine, Humans, Immunology and Allergy, Continuation rate, Retrospective Studies, business.industry, Retrospective cohort study, Imatinib, Health Care Costs, MTOR Inhibitors, Middle Aged, medicine.disease, United States, Graft-versus-host disease, Oncology, Photopheresis, 030220 oncology & carcinogenesis, Chronic Disease, Imatinib Mesylate, Health Resources, Female, business, Resource utilization, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3297108108dc047d6bda21297d33c3Test
https://doi.org/10.2217/imt-2020-0310Test

المؤلفون: David Ebuka Arthur, Jibrin Noah Akoji, Riadh Sahnoun, Greatman C. Okafor, Karimatu Lami Abdullahi, Charles Mgbemena, Samira A. Abdullahi

المصدر: Bulletin of the National Research Centre, Vol 45, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Stereochemistry, Hydrogen interaction, Binding energy, Food and drug administration, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mole, Receptor, lcsh:Science, PI3K/AKT/mTOR pathway, 030304 developmental biology, General Environmental Science, SBDD, 0303 health sciences, Hydrogen bond, Hydrophobic interaction, Ligand (biochemistry), Discovery and development of mTOR inhibitors, chemistry, 030220 oncology & carcinogenesis, Molecular docking, General Earth and Planetary Sciences, lcsh:Q, Drug, Adenosine triphosphate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b530a5f1e6a6450dd168e97d15f717Test
https://doaj.org/article/89f67ef9a17f43c58284770b1b9814d9Test

المؤلفون: Sumit Aggarwal, Sumit Singh Verma, Subash C. Gupta, Sadhna Aggarwal

المصدر: Seminars in Cancer Biology. 68:8-20

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.drug_class, Antineoplastic Agents, Breast Neoplasms, Antimetabolite, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Drug Discovery, medicine, Animals, Humans, Intensive care medicine, Triple-negative breast cancer, Aromatase inhibitor, business.industry, Drug Repositioning, Computational Biology, Cancer, medicine.disease, Discovery and development of mTOR inhibitors, Drug repositioning, 030104 developmental biology, Drug development, 030220 oncology & carcinogenesis, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702f5b98f1929849198dd3eabc7e1d82Test
https://doi.org/10.1016/j.semcancer.2019.09.012Test

المؤلفون: Matteo Santoni, Camillo Porta, Mimma Rizzo

المصدر: Journal of Onco-Nephrology. 4:153-164

مصطلحات موضوعية: 0301 basic medicine, business.industry, medicine.medical_treatment, Immunotherapy, medicine.disease, Discovery and development of mTOR inhibitors, Vascular endothelial growth factor, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Renal cell carcinoma, 030220 oncology & carcinogenesis, Cancer research, Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::10ef544052cb0af64cfaa698fd6f745cTest
https://doi.org/10.1177/2399369320943609Test

المؤلفون: Veronica Mollica, Antonio Lopez-Beltran, Francesco Massari, Alessia Cimadamore, Ilaria Maggio, Michelangelo Fiorentino, Eugenio Brunocilla, Liang Cheng, Francesca Giunchi, Riccardo Schiavina, Alessandro Rizzo, Rodolfo Montironi

المساهمون: Mollica V., Maggio I., Lopez-Beltran A., Montironi R., Cimadamore A., Cheng L., Rizzo A., Giunchi F., Schiavina R., Fiorentino M., Brunocilla E., Massari F.

المصدر: Expert Review of Anticancer Therapy. 20:755-763

مصطلحات موضوعية: 0301 basic medicine, Metastatic Urothelial Carcinoma, Combination therapy, Receptor, ErbB-2, Immune checkpoint inhibitors, Poly ADP ribose polymerase, Disease, Poly(ADP-ribose) Polymerase Inhibitors, DDR, PI3K, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Antineoplastic Combined Chemotherapy Protocols, Humans, DNA damage repair, Urothelial cancer, Medicine, Pharmacology (medical), PARP inhibitors, Immune Checkpoint Inhibitors, urothelial carcinoma, PI3K/AKT/mTOR pathway, Neoplasm Staging, Carcinoma, Transitional Cell, business.industry, TOR Serine-Threonine Kinases, HER-2, mTOR, Discovery and development of mTOR inhibitors, PARP inhibitor, 030104 developmental biology, Urinary Bladder Neoplasms, Oncology, 030220 oncology & carcinogenesis, Cancer research, business

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97aeadce830c00f905b74248e83e9037Test
https://doi.org/10.1080/14737140.2020.1807334Test

المؤلفون: Sunyu Chen, Yang Feng, Zhanhao Xiao, Jiankun Wang

المصدر: Bioscience, Biotechnology, and Biochemistry. 84:989-996

مصطلحات موضوعية: Cartilage, Articular, Male, 0301 basic medicine, Apoptosis, Protective Agents, Autophagy-Related Protein 7, Applied Microbiology and Biotechnology, Biochemistry, Chondrocyte, Autophagy-Related Protein 5, Analytical Chemistry, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Chondrocytes, 0302 clinical medicine, Downregulation and upregulation, Transduction, Genetic, Autophagy, medicine, Humans, Glycosides, Molecular Biology, Protein kinase B, Cells, Cultured, PI3K/AKT/mTOR pathway, Aged, Cell Proliferation, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, General Medicine, Middle Aged, Osteoarthritis, Knee, Discovery and development of mTOR inhibitors, Up-Regulation, Cell biology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Beclin-1, Female, Signal Transduction, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7894d5b376cd0b49d67fbb2f4b4b83cfTest
https://doi.org/10.1080/09168451.2020.1717925Test

المؤلفون: Nicola Fusco, Antonio Ghidini, Gianluca Tomasello, Francesco Grossi, Fausto Petrelli, Andrea Botticelli, Michele Ghidini, Giulia Grizzi, Tommaso Savio, Mary Cabiddu

المصدر: Cancer Management and Research, Vol Volume 12, Pp 675-686 (2020)
Cancer Management and Research

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Estrogen receptor, Review, Palbociclib, lcsh:RC254-282, Aromatase inhibitors, Breast cancer, CDK 4/6 inhibitors, MTOR inhibitors, Neoadjuvant endocrine therapy, PI3K inhibitors, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Abemaciclib, Everolimus, business.industry, Cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Hormonal therapy, business, Tamoxifen, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1827d1c140e47f6f8a458a2962ff8f54Test
https://doi.org/10.2147/cmar.s202965Test