Microbiologically documented infections after adult allogeneic hematopoietic cell transplantation: A 5-year analysis within the Swiss Transplant Cohort study
| العنوان: | Microbiologically documented infections after adult allogeneic hematopoietic cell transplantation: A 5-year analysis within the Swiss Transplant Cohort study |
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| المؤلفون: | Vu, Diem-Lan, Dayer, Julie-Anne, Masouridi-Levrat, Stavroula, Combescure, Christophe, Boely, Elsa, Khanna, Nina, Mueller, Nicolas J, Kleber, Martina, Medinger, Michael, Halter, Joerg, Passweg, Jakob, Müller, Antonia M, Schanz, Urs, Chalandon, Yves, Neofytos, Dionysios, van Delden, Christian, Kaiser, Laurent, Swiss Transplant Cohort Study |
| المساهمون: | Toso, Christian, University of Zurich, Vu, Diem-Lan |
| المصدر: | Transplant Infectious Disease, Vol. 22, No 4 (2020) P. e13289 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Time Factors, Databases, Factual, 10255 Clinic for Thoracic Surgery, 2747 Transplantation, 030230 surgery, 10234 Clinic for Infectious Diseases, 0302 clinical medicine, Recurrence, Risk Factors, hemic and lymphatic diseases, Cumulative incidence, ddc:616, education.field_of_study, ddc:618, ddc:617, Allogeneic cell transplantation, Hematopoietic Stem Cell Transplantation, Bacterial Infections, Middle Aged, 3. Good health, Infectious Diseases, surgical procedures, operative, Virus Diseases, 10209 Clinic for Cardiology, 030211 gastroenterology & hepatology, Female, Infection, Switzerland, Cohort study, Adult, medicine.medical_specialty, Adolescent, Population, Congenital cytomegalovirus infection, 610 Medicine & health, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Transplantation, Homologous, Mortality, education, Aged, Proportional Hazards Models, Retrospective Studies, Transplantation, Proportional hazards model, business.industry, Retrospective cohort study, 2725 Infectious Diseases, medicine.disease, Mycoses, 10032 Clinic for Oncology and Hematology, Complication, business |
| الوصف: | BACKGROUND: Infections are an important complication after allogeneic hematopoietic cell transplantation (allo-HCT). The present study aimed at determining the landscape of infections occurring in a large cohort of allo-HCT patients, as well as associated risk factors for infections and for one-year non-relapse mortality. METHODS: This is a retrospective cohort study using STCS and EBMT databases to assess the one-year incidence rate of infection, as well as risk factors for infections and for one-year non-relapse mortality among adult allo-HCT patients transplanted between 2010 and 2014 in Switzerland. Univariable and multivariable quasi-Poisson and multivariable Cox regression models were used. RESULTS: Of 553 patients included, 486 had an infection with a global incidence rate of 3.66 infections per patient-year. Among a total of 1534 infections analyzed, viral infections were predominant (n = 1138, 74.2%), followed by bacterial (n = 343, 22.4%) and fungal (n = 53, 3.5%) infections. At one year, the cumulative incidence of relapse and non-relapse mortality was 26% and 16%, respectively. 195 (35.3%) of patients had at least one episode of severe graft-versus-host-disease (GvHD). A center effect was observed, and underlying disease, donor type, cytomegalovirus serological constellation, and GvHD were also associated with the incidence rate of infections. There was an increased risk for one-year non-relapse mortality associated with all pathogens, specifically within two months of infection, and this remained true beyond 2 months of a fungal infection. CONCLUSION: Despite advances to limit infections in this population, they still occur in most allo-HCT patients with a major impact on survival at 1 year. |
| تدمد: | 1399-3062 1398-2273 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feba653e907f25ce52302b2d3234525Test https://pubmed.ncbi.nlm.nih.gov/32277837Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....0feba653e907f25ce52302b2d3234525 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993062 13982273 |
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