Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions
| العنوان: | Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions |
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| المؤلفون: | Sandra Gegunde, Amparo Alfonso, Rebeca Alvariño, Eva Alonso, Luis M. Botana |
| المساهمون: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela Universidad de Santiago de Compostela (USC) Frontiers in Immunology Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell physiology, lcsh:Immunologic diseases. Allergy, T-Lymphocytes, Immunology, Gene Expression, Cypa, Inflammation, 030204 cardiovascular system & hematology, Ligands, migration, 03 medical and health sciences, Cyclophilins, Structure-Activity Relationship, 0302 clinical medicine, Cyclophilin A inhibitors, Cell surface receptor, Drug Discovery, CD147 receptor, medicine, T lymphocyte, Immunology and Allergy, Humans, Receptor, Cyclophilin, Migration, Original Research, Biological Products, biology, Chemistry, Chemotaxis, cyclophilin A inhibitors, Cell migration, biology.organism_classification, 3. Good health, Cell biology, 030104 developmental biology, inflammation, cyclophilin, Disease Susceptibility, medicine.symptom, lcsh:RC581-607, Biomarkers, Protein Binding |
| الوصف: | Cyclophilins (Cyps) are a group of peptidyl-prolyl cis/trans isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions. Their receptor, CD147, also participates in the development and progression of the inflammatory response. Nevertheless, the main function of Cyps and their receptor are yet to be deciphered. The release of CypA and the expression of the CD147 receptor in activated T lymphocytes were already described, however, no data are available about other Cyps in these cells. Therefore, in the present work intra and extracellular CypA, B and C levels were measured followed by induced inflammatory conditions. After activation of T lymphocytes by incubation with concanavalin A, both intra and extracellular Cyps levels and the CD147 membrane receptor expression were increased leading to cell migration towards circulating CypA and CypB as chemoattractants. When CypA was modulated by natural and synthetic compounds, the inflammatory cascade was avoided including T cell migration. Our results strengthen the relationship between CypA, B, and C, their receptor, and the inflammatory process in human T lymphocytes, associating CypC with these cells for the first time The research leading to these results has received funding from the following FEDER cofunded-grants. From Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, Spain, 2017 GRC GI-1682 (ED431C 2017/01). From CDTI and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad, Spain, ISCIII/PI19/01248, ISCIII/PI19/00879. In European Union, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX. SG was supported by a fellowship from FIDIS, Spain SI |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9c0ebab767978768f443cd1c5aa5d2Test https://www.frontiersin.org/articles/10.3389/fimmu.2021.609196/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d9c0ebab767978768f443cd1c5aa5d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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