أعرض في EDS

Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms

التفاصيل البيبلوغرافية
العنوان: Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms
المؤلفون: Edith Bigot-Corbel, Cédric Cleyrat, Eun Ho Eunice Choi, Laura Dufeu, Jean-Marc Gombert, François Girodon, Sophie Allain-Maillet, Nicolas Mennesson, Adrien Bosseboeuf, Yannick Le Bris, Olivier Mansier, Eric Lippert, Magali Pettazzoni, Sylvie Hermouet, Mégane Bostoën
المساهمون: Molecular Mechanisms of Chronic Inflammation in Hematological Diseases (CRCINA-ÉQUIPE 16), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), The University of New Mexico [Albuquerque], Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Hématologie [CHU Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, CHRU Brest - Service d'Hématologie (CHU-Brest-Hemato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA-ÉQUIPE 10), Service d'Hématologie [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'immunologie [CHU Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Service d'Hématologie Clinique (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Biochimie et Biologie Moléculaire Grand Est [HCL, Lyon] (Centre de Biologie et de Pathologie), Hospices Civils de Lyon (HCL), Laboratoire de Biochimie [Nantes], Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Bernardo, Elizabeth
المصدر: Cancers
Cancers, MDPI, 2020, 12 (9), pp.E2446. ⟨10.3390/cancers12092446⟩
Cancers, 2020, 12 (9), pp.E2446. ⟨10.3390/cancers12092446⟩
Cancers, Vol 12, Iss 2446, p 2446 (2020)
Volume 12
Issue 9
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, IL-1Rα, medicine.medical_treatment, Clone (cell biology), interleukin-1β (IL-1β), Inflammation, [SDV.CAN]Life Sciences [q-bio]/Cancer, myeloproliferative neoplasms (MPNs), CALR exon 9 mutants, IP-10, medicine.disease_cause, lcsh:RC254-282, leptin, Article, Autoimmunity, Proinflammatory cytokine, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Polycythemia vera, JAK2V617F, [SDV.CAN] Life Sciences [q-bio]/Cancer, glucolipids, hemic and lymphatic diseases, medicine, article clinique, auto-immunity, antigenic stimulation, business.industry, CRISPR technology, UT-7, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, glucosylsphingosine (GlcSph), cytokines, 3. Good health, Interleukin 33, 030104 developmental biology, Cytokine, Oncology, inflammation, 030220 oncology & carcinogenesis, Immunology, IL-33, medicine.symptom, business
الوصف: Inflammatory cytokines play a major role in myeloproliferative neoplasms (MPNs) as regulators of the MPN clone and as mediators of clinical symptoms and complications. Firstly, we investigated the effect of JAK2V617F on 42 molecules linked to inflammation. For JAK2V617F-mutated patients, the JAK2V617F allele burden (%JAK2V617F) correlated with the levels of IL-1&beta
IL-1R&alpha
IP-10 and leptin in polycythemia vera (PV), and with IL-33 in ET
for all other molecules, no correlation was found. Cytokine production was also studied in the human megakaryocytic cell line UT-7. Wild-type UT-7 cells secreted 27/42 cytokines measured. UT-7 clones expressing 50% or 75% JAK2V617F were generated, in which the production of IL-1&beta
IP-10 and RANTES was increased
other cytokines were not affected. Secondly, we searched for causes of chronic inflammation in MPNs other than driver mutations. Since antigen-driven selection is increasingly implicated in the pathogenesis of blood malignancies, we investigated whether proinflammatory glucosylsphingosine (GlcSph) may play a role in MPNs. We report that 20% (15/75) of MPN patients presented with anti-GlcSph IgGs, distinguished by elevated levels of 11 cytokines. In summary, only IL-1&beta
and IP-10 were linked to JAK2V617F both in patients and in UT-7 cells
other inflammation-linked cytokines in excess in MPNs were not. For subsets of MPN patients, a possible cause of inflammation may be auto-immunity against glucolipids.
وصف الملف: application/pdf
تدمد: 2072-6694
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7809f8c9ddf86ce1f6dca09a3c5ee978Test
https://pubmed.ncbi.nlm.nih.gov/32872203Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....7809f8c9ddf86ce1f6dca09a3c5ee978
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20726694