المؤلفون: Filippo Mirabella, Marco Rasile, Eliana Lauranzano, Michela Matteoli

المصدر: The Febs Journal

مصطلحات موضوعية: 0301 basic medicine, Brain vasculature, Coronavirus disease 2019 (COVID-19), long‐COVID, Neuronal migration, State‐Of‐The‐Art Reviews, blood–brain barrier, Bioinformatics, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, COVID‐19, synapse, Animals, Humans, State‐Of‐The‐Art Review, Medicine, prenatal viral infection, Pregnancy Complications, Infectious, neurovascular unit, Perinatal infections, Molecular Biology, maternal immune activation, business.industry, Mental Disorders, Brain, COVID-19, Cell Biology, Neurovascular bundle, medicine.disease, cytokines, 030104 developmental biology, inflammation, Prenatal Exposure Delayed Effects, 030220 oncology & carcinogenesis, Damages, Etiology, Female, hemorrhage, business

الوصف: Intragravidic and perinatal infections, acting through either direct viral effect or immune‐mediated responses, are recognized causes of liability for neurodevelopmental disorders in the progeny. The large amounts of epidemiological data and the wealth of information deriving from animal models of gestational infections have contributed to delineate, in the last years, possible underpinning mechanisms for this phenomenon, including defects in neuronal migration, impaired spine and synaptic development, and altered activation of microglia. Recently, dysfunctions of the neurovascular unit and anomalies of the brain vasculature have unexpectedly emerged as potential causes at the origin of behavioral abnormalities and psychiatric disorders consequent to prenatal and perinatal infections. This review aims to discuss the up‐to‐date literature evidence pointing to the neurovascular unit and brain vasculature damages as the etiological mechanisms in neurodevelopmental syndromes. We focus on the inflammatory events consequent to intragravidic viral infections as well as on the direct viral effects as the potential primary triggers. These authors hope that a timely review of the literature will help to envision promising research directions, also relevant for the present and future COVID‐19 longitudinal studies.
Intragravidic and perinatal infections are recognized causes of liability for neurodevelopmental disorders in the progeny. This review aims to discuss the up‐to‐date evidence pointing to the neurovascular unit and brain vasculature damages as the etiological mechanisms. We focus on the inflammatory events consequent to intragravidic viral infections as well as on the direct viral effects as the potential primary triggers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e817ef187786eef526660ff0b0f216fTest
https://doi.org/10.1111/febs.16020Test

المؤلفون: Marco Morreale, Filippo Mirabella, Francesco Paolo La Mantia, Roberto Scaffaro

المصدر: Macromolecular Materials and Engineering. 296:141-150

مصطلحات موضوعية: chemistry.chemical_compound, Materials science, Lactide, Polymers and Plastics, Rheology, Chemical engineering, Scale (ratio), chemistry, General Chemical Engineering, Organic Chemistry, Materials Chemistry, macromolecular substances, Composite material

الوصف: Poly(lacticacid)(PLA)hasbeengainingarisinginterestoverthe last years as a biodegradable and environmental-friendly substitute of traditional non-biodegradable poly-mers.Several ways exist to synthesize PLA, however, poly-merization through lactide formation is the most used onindustrial scale, allowing to obtain optimum results interms of mechanical and thermal properties.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f2265567d0d8bf33a5df02c9b37ba66bTest
https://doi.org/10.1002/mame.201000221Test