Neurological consequences of neurovascular unit and brain vasculature damages: potential risks for pregnancy infections and COVID‐19‐babies
| العنوان: | Neurological consequences of neurovascular unit and brain vasculature damages: potential risks for pregnancy infections and COVID‐19‐babies |
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| المؤلفون: | Filippo Mirabella, Marco Rasile, Eliana Lauranzano, Michela Matteoli |
| المصدر: | The Febs Journal |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Brain vasculature, Coronavirus disease 2019 (COVID-19), long‐COVID, Neuronal migration, State‐Of‐The‐Art Reviews, blood–brain barrier, Bioinformatics, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, COVID‐19, synapse, Animals, Humans, State‐Of‐The‐Art Review, Medicine, prenatal viral infection, Pregnancy Complications, Infectious, neurovascular unit, Perinatal infections, Molecular Biology, maternal immune activation, business.industry, Mental Disorders, Brain, COVID-19, Cell Biology, Neurovascular bundle, medicine.disease, cytokines, 030104 developmental biology, inflammation, Prenatal Exposure Delayed Effects, 030220 oncology & carcinogenesis, Damages, Etiology, Female, hemorrhage, business |
| الوصف: | Intragravidic and perinatal infections, acting through either direct viral effect or immune‐mediated responses, are recognized causes of liability for neurodevelopmental disorders in the progeny. The large amounts of epidemiological data and the wealth of information deriving from animal models of gestational infections have contributed to delineate, in the last years, possible underpinning mechanisms for this phenomenon, including defects in neuronal migration, impaired spine and synaptic development, and altered activation of microglia. Recently, dysfunctions of the neurovascular unit and anomalies of the brain vasculature have unexpectedly emerged as potential causes at the origin of behavioral abnormalities and psychiatric disorders consequent to prenatal and perinatal infections. This review aims to discuss the up‐to‐date literature evidence pointing to the neurovascular unit and brain vasculature damages as the etiological mechanisms in neurodevelopmental syndromes. We focus on the inflammatory events consequent to intragravidic viral infections as well as on the direct viral effects as the potential primary triggers. These authors hope that a timely review of the literature will help to envision promising research directions, also relevant for the present and future COVID‐19 longitudinal studies. Intragravidic and perinatal infections are recognized causes of liability for neurodevelopmental disorders in the progeny. This review aims to discuss the up‐to‐date evidence pointing to the neurovascular unit and brain vasculature damages as the etiological mechanisms. We focus on the inflammatory events consequent to intragravidic viral infections as well as on the direct viral effects as the potential primary triggers. |
| تدمد: | 1742-4658 1742-464X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e817ef187786eef526660ff0b0f216fTest https://doi.org/10.1111/febs.16020Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8e817ef187786eef526660ff0b0f216f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17424658 1742464X |
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