نتائج البحث

1

Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

المؤلفون: Raymond Evers, Shinji Yamazaki, Loeckie de Zwart

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 55-67 (2022)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Quinidine, Adult, Male, Physiologically based pharmacokinetic modelling, Digoxin, endocrine system diseases, Metabolic Clearance Rate, RM1-950, Pharmacology, Models, Biological, Article, Young Adult, Pharmacokinetics, In vivo, medicine, polycyclic compounds, Humans, Pharmacology (medical), Computer Simulation, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, biology, Dose-Response Relationship, Drug, integumentary system, Chemistry, Research, Transporter, Articles, Middle Aged, In vitro, female genital diseases and pregnancy complications, Dabigatran, Intestines, carbohydrates (lipids), Verapamil, Modeling and Simulation, Area Under Curve, biology.protein, Female, Therapeutics. Pharmacology, Itraconazole, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7452e9e21c70c96573c9224133ea1136Test
https://doaj.org/article/85d43d144eb645dc92ef1b14fa39c67cTest

2

MALAT1 shuttled by extracellular vesicles promotes M1 polarization of macrophages to induce acute pancreatitis via miR‐181a‐5p/HMGB1 axis

المؤلفون: Jie Liu, Rui Zhang, Longfei Pan, Zhong Liu, Zhuo Peng, Honghong Pei, Zequn Niu, Yanxia Gao, Liming Wang

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: Male, Apoptosis, Mice, Databases, Genetic, HMGB1 Protein, MALAT1, biology, Chemistry, NF-kappa B, Middle Aged, Long non-coding RNA, Hedgehog signaling pathway, Cell biology, long non‐coding RNA, metastasis‐associated lung adenocarcinoma transcript‐1, Molecular Medicine, Female, RNA, Long Noncoding, Original Article, Disease Susceptibility, Signal Transduction, Adult, acute pancreatitis, HMGB1, M1 polarization of macrophages, Extracellular Vesicles, Downregulation and upregulation, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Gene Silencing, high‐mobility group box 1 protein, Aged, Gene Expression Profiling, Macrophages, Original Articles, Cell Biology, Macrophage Activation, medicine.disease, Toll-Like Receptor 4, Disease Models, Animal, MicroRNAs, Gene Expression Regulation, Pancreatitis, microRNA‐181a‐5p, TLR4, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27df26b7f48ddb68d1f834cedeb2b07Test
https://doi.org/10.1111/jcmm.16844Test

3

Relationship of hemoglobin level and plasma coproporphyrin‐I concentrations as an endogenous probe for phenotyping OATP1B

المؤلفون: Masahiro Nakatochi, Michiaki Kubo, Keiko Ohno, Teruhide Koyama, Ayako Oda, Chisato Yoshijima, Ritei Uehara, Yukihide Momozawa, Yosuke Suzuki, Yuri Sasamoto

المصدر: Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 4, Pp 1403-1411 (2021)

مصطلحات موضوعية: Adult, Male, Coproporphyrins, medicine.medical_specialty, Population, Endogeny, RM1-950, Heme, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, Hemoglobins, Basal (phylogenetics), Polymorphism (computer science), Internal medicine, medicine, Humans, Precision Medicine, General Pharmacology, Toxicology and Pharmaceutics, Allele, education, Alleles, Aged, education.field_of_study, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Research, General Neuroscience, Articles, General Medicine, Middle Aged, Organic anion-transporting polypeptide, Endocrinology, biology.protein, Biomarker (medicine), Female, Therapeutics. Pharmacology, Hemoglobin, Public aspects of medicine, RA1-1270, Biomarkers, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd4de6e96882d14c08ee0350bf37c7dTest
https://doi.org/10.1111/cts.12996Test

4

Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis

المؤلفون: Márton Doleschall, Anikó Somogyi, Magdolna Herold, Zoltán Herold, Attila Patócs, Peter Nagy

المصدر: Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 865-873 (2020)
Journal of Diabetes Investigation

مصطلحات موضوعية: 0301 basic medicine, Male, Endocrinology, Diabetes and Metabolism, Neuroendocrine tumors, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Prospective Studies, biology, C-Peptide, Glutamate Decarboxylase, Chromogranin A, Enterochromaffin‐like cell hyperplasia, General Medicine, Articles, Hyperplasia, Clinical Science and Care, Autoimmune gastritis, Gastritis, Disease Progression, Biomarker (medicine), Female, Original Article, Adult, medicine.medical_specialty, endocrine system, Enterochromaffin-like Cells, Autoimmune Gastritis, 030209 endocrinology & metabolism, Diseases of the endocrine glands. Clinical endocrinology, Autoimmune Diseases, 03 medical and health sciences, Islets of Langerhans, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Autoantibodies, Glycated Hemoglobin, Type 1 diabetes, Hungary, business.industry, medicine.disease, RC648-665, 030104 developmental biology, Diabetes Mellitus, Type 1, chemistry, biology.protein, Glycated hemoglobin, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741a714d78d44aaf78f9e4604804fd0eTest
https://doaj.org/article/3dbcf3ebbb9e4c5da1e3b87698b4805eTest

5

Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic Regulation ofBTBandCNCHomolog 2 by the MethyltransferaseEZH2

المؤلفون: Shingo Nakayamada, Masanobu Ueno, Tong Zhang, Mingzeng Zhang, Maiko Hajime, Naoaki Ohkubo, Shigeru Iwata, Hiroko Miyata, Jie Fan, Kaoru Yamagata, Yasuyuki Todoroki, He Hao, Yoshiya Tanaka

المصدر: Arthritis & Rheumatology. 72:1143-1153

مصطلحات موضوعية: Adult, Male, X-Box Binding Protein 1, 0301 basic medicine, Methyltransferase, Plasma Cells, Immunology, B-cell receptor, mTORC1, Mechanistic Target of Rapamycin Complex 1, CD19, Epigenesis, Genetic, 03 medical and health sciences, chemistry.chemical_compound, Methionine, 0302 clinical medicine, Rheumatology, Interferon, medicine, Humans, Lupus Erythematosus, Systemic, Syk Kinase, Immunology and Allergy, Enhancer of Zeste Homolog 2 Protein, Amino Acids, Cells, Cultured, B cell, Autoantibodies, chemistry.chemical_classification, biology, Precursor Cells, B-Lymphoid, Cell Differentiation, Middle Aged, Amino acid, Cell biology, Basic-Leucine Zipper Transcription Factors, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, chemistry, Case-Control Studies, biology.protein, Female, Positive Regulatory Domain I-Binding Factor 1, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f83c76a30bddc46586697dcc78ae03Test
https://doi.org/10.1002/art.41208Test

6

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

المؤلفون: Shuichi Hashimoto, Hiromitsu Morita, Akimitsu Hiraki, Shohei Yoshimoto, Fumie Tanaka

المصدر: Cancer Medicine, Vol 8, Iss 18, Pp 7822-7832 (2019)
Cancer Medicine

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, Adolescent, Cell, medicine.disease_cause, lcsh:RC254-282, Malignant transformation, ameloblastoma, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Humans, Radiology, Nuclear Medicine and imaging, Epithelial–mesenchymal transition, Hypoxia, Ameloblastoma, Aged, Original Research, Cancer Biology, odontogenic tumors, transforming growth factor beta, epithelial‐mesenchymal transition, biology, Chemistry, Gene Expression Profiling, Zinc Finger E-box-Binding Homeobox 1, Transforming growth factor beta, Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Immunohistochemistry, Cell Transformation, Neoplastic, 030104 developmental biology, HIF1A, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Carcinogenesis, carcinogenesis, Transforming growth factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d66ea9e982e349a0b95730d9a9531dTest
https://doi.org/10.1002/cam4.2667Test

7

Protein‐carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle

المؤلفون: Stewart Jeromson, Jessica R. Dent, Zhe Song, Leigh Breen, Simon W. Jones, Andrew Philp, Nathan Hodson, James Murray, D. Lee Hamilton, Mary F. O’Leary, Thomas Nicholson

المصدر: Experimental Physiology. 105:2178-2189

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Physiology, Muscle Fibers, Skeletal, Carbohydrates, P70-S6 Kinase 1, mTORC1, 030204 cardiovascular system & hematology, Cell Line, Eating, Mice, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Animals, Humans, Kinase activity, Muscle, Skeletal, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Cellular localization, Nutrition and Dietetics, biology, Myogenesis, Chemistry, TOR Serine-Threonine Kinases, fungi, Skeletal muscle, General Medicine, Middle Aged, Class III Phosphatidylinositol 3-Kinases, Endocrinology, medicine.anatomical_structure, biology.protein, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bf3f9c38af16ea81a3f00a8f595157Test
https://doi.org/10.1113/ep088805Test

8

Synergistic effect of ibrutinib and CD19 CAR‐T cells on Raji cells in vivo and in vitro

المؤلفون: Yanyu Jiang, Q Deng, Rui Zhang, Lei Sun, Juan Mu, Meijing Liu, Zheng Li, Xuelin Wang

المصدر: Cancer Science

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, programmed cell death‐ligand 1, T-Lymphocytes, Chronic lymphocytic leukemia, Cell, Immunotherapy, Adoptive, Mice, chemistry.chemical_compound, Basic and Clinical Immunology, Raji cell line, 0302 clinical medicine, Piperidines, hemic and lymphatic diseases, chimeric antigen receptor, medicine.diagnostic_test, biology, Chemistry, General Medicine, Middle Aged, Combined Modality Therapy, Raji cell, Treatment Outcome, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Ibrutinib, Original Article, Female, Lymphoma, Large B-Cell, Diffuse, Adult, STAT3 Transcription Factor, Antigens, CD19, Receptors, Antigen, T-Cell, Bruton tyrosine kinase inhibitor, CD19, Immunophenotyping, Flow cytometry, 03 medical and health sciences, In vivo, Cell Line, Tumor, Biomarkers, Tumor, medicine, tumor microenvironment, Animals, Humans, Protein Kinase Inhibitors, Aged, Neoplasm Staging, Tumor microenvironment, Adenine, Original Articles, medicine.disease, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, biology.protein, Cancer research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49d2425f68eed7413004c23fbb5d00bTest
https://doi.org/10.1111/cas.14638Test

9

Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type II Diabetes Mellitus

المؤلفون: Alexander T. Hillel, Ruth J. Davis, Hsiu-Wen Tsai, Kevin M. Motz, Dacheng Ding, Ioan A. Lina

المصدر: Laryngoscope

مصطلحات موضوعية: Male, endocrine system diseases, Biopsy, Iatrogenic Disease, Constriction, Pathologic, Phenformin, Oxidative Phosphorylation, chemistry.chemical_compound, Tracheostomy, 0302 clinical medicine, Myofibroblasts, 030223 otorhinolaryngology, Cells, Cultured, biology, Middle Aged, Metformin, Trachea, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Amobarbital, Female, Tracheal Stenosis, Glycolysis, Myofibroblast, Muscle Contraction, medicine.drug, Adult, Glottis, medicine.medical_specialty, Primary Cell Culture, Article, Contractility, Cicatrix, Young Adult, 03 medical and health sciences, Internal medicine, Intubation, Intratracheal, medicine, Humans, Hypoglycemic Agents, Fibroblast, Aged, Cell Proliferation, business.industry, nutritional and metabolic diseases, Laryngostenosis, Fibronectin, Collagen, type I, alpha 1, Endocrinology, Diabetes Mellitus, Type 2, Otorhinolaryngology, chemistry, Case-Control Studies, biology.protein, Energy Metabolism, business, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d48ca1ac1d15b39afc6fb0f8868387Test
https://doi.org/10.1002/lary.29026Test

10

Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver

المؤلفون: Xiaojuan Yu, Youzhi Xu, Wenjie Lu, Qianqian Sun, Wentong Chen, Jie Jiang, Hu Xu, Ning Liu, Hongquan Wei

المصدر: The FASEB Journal. 34:13474-13493

مصطلحات موضوعية: Adult, Male, STAT3 Transcription Factor, 0301 basic medicine, medicine.medical_specialty, Hyperuricemia, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, In vivo, Internal medicine, Phosphatidylcholine, Lipidomics, Genetics, medicine, Animals, Humans, STAT3, Molecular Biology, Triglycerides, biology, 1-Acylglycerophosphocholine O-Acyltransferase, nutritional and metabolic diseases, Hep G2 Cells, Middle Aged, medicine.disease, In vitro, Uric Acid, Lipoproteins, LDL, Mice, Inbred C57BL, Cholesterol, 030104 developmental biology, Endocrinology, Liver, chemistry, Case-Control Studies, Gene Knockdown Techniques, biology.protein, Uric acid, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, 030217 neurology & neurosurgery, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f171057dd1544584c4a125b5cd1aed55Test
https://doi.org/10.1096/fj.202000950rTest

تنقيح النتائج