Live virus neutralization testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2
| العنوان: | Live virus neutralization testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2 |
|---|---|
| المؤلفون: | Saade, Carla, Gonzalez, Claudia, Bal, Antonin, Valette, Martine, Saker, Kahina, Lina, Bruno, Josset, Laurence, Trabaud, Mary-Anne, Thiery, Guillaume, Botelho-Nevers, Elisabeth, Paul, Stéphane, Verhoeven, Paul, Bourlet, Thomas, Pillet, Sylvie, Morfin, Florence, Trouillet-Assant, Sophie, Pozzetto, Bruno, on behalf of COVID-SER study group |
| المصدر: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Letter, COVID-19 Vaccines, SARS-CoV-2, COVID-19, Antibodies, Viral, Antibodies, Neutralizing, 20H/501Y.V2, Neutralization Tests, 20I/501Y.V1, Humans, live virus neutralization test, variant of concern, humoral response, 20B |
| الوصف: | SARS-CoV-2 mutations appeared recently and can lead to conformational changes in the spike protein and probably induce modifications in antigenicity. We assessed the neutralizing capacity of antibodies to prevent cell infection, using a live virus neutralization test with different strains [19A (initial one), 20B (B.1.1.241 lineage), 20I/501Y.V1 (B.1.1.7 lineage), and 20H/501Y.V2 (B.1.351 lineage)] in serum samples collected from different populations: two-dose vaccinated COVID-19-naive healthcare workers (HCWs; Pfizer-BioNTech BNT161b2), 6-months post mild COVID-19 HCWs, and critical COVID-19 patients. No significant difference was observed between the 20B and 19A isolates for HCWs with mild COVID-19 and critical patients. However, a significant decrease in neutralization ability was found for 20I/501Y.V1 in comparison with 19A isolate for critical patients and HCWs 6-months post infection. Concerning 20H/501Y.V2, all populations had a significant reduction in neutralizing antibody titers in comparison with the 19A isolate. Interestingly, a significant difference in neutralization capacity was observed for vaccinated HCWs between the two variants but not in the convalescent groups. |
| اللغة: | English |
| تدمد: | 2222-1751 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::4a11f240820c3e2af38ee1fe34dcf151Test http://europepmc.org/articles/PMC8330769Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........4a11f240820c3e2af38ee1fe34dcf151 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22221751 |
|---|