المؤلفون: Hao Qiang, Qihui Sun, Xi Zheng, Ming Qi, Mengzhen Chen, Nengneng Luo, Chao Xu, Xiaohui Ye

المصدر: Journal of Materials Science. 58:8178-8188

مصطلحات موضوعية: Mechanics of Materials, Mechanical Engineering, General Materials Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ab65730dd9fbb4d41d1772414460e31eTest
https://doi.org/10.1007/s10853-023-08509-0Test

المؤلفون: Ting Liu, Lei Sun, Zhi-zhao Li, Kun Yang, Jia-min Chen, Xiao-yi Han, Li-ming Qi, Xin-gang Zhou, Peng Wang

المصدر: BMC Gastroenterology. 23

مصطلحات موضوعية: Gastroenterology, General Medicine

الوصف: Background RNA methylation is a crucial in many biological functions, and its aberrant regulation is associated with cancer progression. N6-Methyladenosine (m6A), 5-Methylcytosine (m5C), N1-methyladenosine (m1A) are common modifications of RNA methylation. However, the effect of methylation of m6A/m5C/m1A in hepatocellular carcinoma (HCC) remains unclear. Method The transcriptome datasets, clinic information, and mutational data of 48 m6A/m5C/m1A regulator genes were acquired from the TCGA database, and the prognostic hazard model was established by univariate and Least absolute shrinkage and selection operator (Lasso) regression. The multivariate regression was performed to determine whether the risk score was an independent prognostic indicator. Kaplan–Meier survival analysis and ROC curve analysis were used to evaluate the predictive ability of the risk model. Decision curve analysis（DCA）analysis was conducted to estimate the clinical utility of the risk model. We further analyzed the association between risk score and functional enrichment, tumor immune microenvironment, and somatic mutation. Result The four-gene (YTHDF1, YBX1, TRMT10C, TRMT61A) risk signature was constructed. The high-risk group had shorter overall survival (OS) than the low-risk group. Univariate and multivariate regression analysis indicated that risk score was an independent prognostic indicator. Risk scores in male group, T3 + T4 group and Stage III + IV group were higher in female group, T1 + T2 group and stage I + II group. The AUC values for 1-, 2-, and 3-year OS in the TCGA dataset were 0.764, 0.693, and 0.689, respectively. DCA analysis showed that the risk score had a higher clinical net benefit in 1- and 2-year OS than other clinical features.The risk score was positively related to some immune cell infiltration and most immune checkpoints. Conclusion We developed a novel m6A/m5C/m1A regulator genes' prognostic model, which could be applied as a latent prognostic tool for HCC and might guide the choice of immunotherapies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::aa6493f1b3cb5ea8f982458072bd5b45Test
https://doi.org/10.1186/s12876-023-02776-6Test

المؤلفون: Hongmei Jing, Li Yang, Junyuan Qi, Lugui Qiu, Chengcheng Fu, Junmin Li, Min Yang, Ming Qi, Ni Fan, Jia Ji, Jiajia Lu, Yunan Li, Jie Jin

المصدر: Annals of Hematology. 101:2679-2690

مصطلحات موضوعية: China, Antineoplastic Combined Chemotherapy Protocols, Humans, Antibodies, Monoclonal, Hematology, General Medicine, Multiple Myeloma, Progression-Free Survival, Dexamethasone

الوصف: Daratumumab monotherapy demonstrated favorable safety and efficacy in relapsed/refractory multiple myeloma (RRMM) patients in the global phase 1/2 GEN501 and phase 2 SIRIUS studies. MMY1003 evaluated daratumumab monotherapy specifically in Chinese patients with RRMM. This 3-part, open-label, phase 1, dose-escalation study included patients with ≥ 2 prior lines of therapy. Part 3 included patients who had received a proteasome inhibitor (PI) and immunomodulatory drug (IMiD) and experienced disease progression on their last regimen. Patients received intravenous daratumumab 8 mg/kg or 16 mg/kg in part 1 and 16 mg/kg in parts 2 + 3. Primary endpoints were dose-limiting toxicity (DLT; part 1), pharmacokinetics (parts 1 + 2), and adverse events (AEs). Fifty patients enrolled. The first 3 patients in part 1 received daratumumab 8 mg/kg; remaining patients in parts 1–3 received daratumumab 16 mg/kg. In the daratumumab 16 mg/kg group (n = 47), patients received a median of 4 prior lines of therapy; 32% were refractory to a PI and IMiD, and 79% were refractory to their last prior therapy. No DLTs occurred. Thirty-six (77%) patients reported grade 3/4 treatment-emergent AEs. Thirteen (28%) patients experienced infusion-related reactions. At an 18.5-month median follow-up, overall response rate was 43%. Median progression-free survival (PFS) and overall survival (OS) were 6.7 months and not reached, respectively; 12-month PFS and OS rates were 35% and 70%. Pharmacokinetic results (n = 22) were consistent with other studies. Safety, pharmacokinetics, and efficacy of daratumumab monotherapy were confirmed in Chinese patients with RRMM. This trial is registered on ClinicalTrials.gov (NCT02852837).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d6c442099665628df7a6e25f60d163Test
https://doi.org/10.1007/s00277-022-04951-3Test

المؤلفون: Chang-Lin, Wang, Ming-Zhou, Gao, Xiang-Ju, Gao, Xiang-Yu, Mu, Jie-Qiong, Wang, Dong-Mei, Gao, Ming-Qi, Qiao

المصدر: Chinese Journal of Integrative Medicine. 29:566-576

مصطلحات موضوعية: Complementary and alternative medicine, Pharmacology (medical), General Medicine

الوصف: Nodular goiter has become increasingly prevalent in recent years. Clinically, there has been a burgeoning interest in nodular goiter due to the risk of progression to thyroid cancer. This review aims to provide a comprehensive summary of the mechanisms underlying the therapeutic effect of Chinese medicine (CM) in nodular goiter. Articles were systematically retrieved from databases, including PubMed, Web of Science and China National Knowledge Infrastructure. New evidence showed that CM exhibited multi-pathway and multi-target characteristics in the treatment of nodular goiter, involving hypothalamus-pituitary-thyroid axis, oxidative stress, blood rheology, cell proliferation, apoptosis, and autophagy, especially inhibition of cell proliferation and promotion of cell apoptosis, involving multiple signal pathways and a variety of cytokines. This review provides a scientific basis for the therapeutic use of CM against nodular goiter. Nonetheless, future studies are warranted to identify more regulatory genes and pathways to provide new approaches for the treatment of nodular goiter.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0803480289b0d51a60affa78f6fefa67Test
https://doi.org/10.1007/s11655-022-3724-3Test

المؤلفون: Yi Chen, Tao Lin, Chang-Bing Wang, Wan-Li Liang, Guang-Wan Lian, Mark Zanin, Sook-San Wong, Xin-Gui Tian, Jia-Yu Zhong, Ying-Ying Zhang, Jia-Hui Xie, Ling-Ling Zheng, Fei-Yan Chen, Run Dang, Ming-Qi Zhao, Yi-Yu Yang, Rong Zhou, Bing Zhu

المصدر: World Journal of Pediatrics. 18:545-552

مصطلحات موضوعية: Adenovirus Infections, Human, China, Molecular Epidemiology, Adenoviruses, Human, Pediatrics, Perinatology and Child Health, COVID-19, Humans, Infant, Female, Child, Respiratory Tract Infections, Phylogeny, Retrospective Studies

الوصف: Background Human adenovirus (HAdV) infection can cause a variety of diseases. It is a major pathogen of pediatric acute respiratory tract infections (ARIs) and can be life-threatening in younger children. We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou, China. Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021. HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis. Results Before the COVID-19 outbreak in Guangzhou, the annual frequency of adenovirus infection detected during this period ranged from 3.92% to 13.58%, with an epidemic peak every four to five years. HAdV demonstrated a clear seasonal distribution, with the lowest positivity in March and peaking during summer (July or August) every year. A significant increase in HAdV cases was recorded for 2018 and 2019, which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7. The latter was associated with a more severe disease compared to HAdV-3. The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38% but increased to 20% in severe cases. After COVID-19 emerged, HAdV cases dropped to 2.68%, suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community. Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c54809c86ab9beef721c9bc3fcfc8e1Test
https://doi.org/10.1007/s12519-022-00590-wTest

المؤلفون: Tong Liu, Xiangyu Wang, Zhikai Cao, Yue Xu, Zhongfen An, Fuzhou Song, Feng Shi, Ze-Ming Qi, Lingcui Zhang

المصدر: Journal of Materials Science: Materials in Electronics. 33:12573-12583

مصطلحات موضوعية: Electrical and Electronic Engineering, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::01900259dac1afc5c7cc332e4a0373bdTest
https://doi.org/10.1007/s10854-022-08173-1Test

المؤلفون: Wen Wang, Qiao He, Ming-qi Wang, Jia-yue Xu, Peng Ji, Rui Zhang, Kang Zou, Xin Sun

المصدر: Chinese Journal of Integrative Medicine.

مصطلحات موضوعية: Complementary and alternative medicine, Pharmacology (medical), General Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::09f860585713a32f770b8d991bedc2faTest
https://doi.org/10.1007/s11655-023-3634-zTest

المؤلفون: Philippe Moreau, Ajai Chari, Albert Oriol, Joaquin Martinez-Lopez, Mathias Haenel, Cyrille Touzeau, Sikander Ailawadhi, Britta Besemer, Javier de la Rubia Comos, Cristina Encinas, Maria-Victoria Mateos, Hans Salwender, Paula Rodriguez-Otero, Cyrille Hulin, Lionel Karlin, Anna Sureda Balari, Joan Bargay, Lotfi Benboubker, Laura Rosiñol, Stefano Tarantolo, Howard Terebelo, Shiyi Yang, Jianping Wang, Ivo Nnane, Ming Qi, Michele Kosh, Maria Delioukina, Hartmut Goldschmidt

المصدر: Blood Cancer Journal. 13

مصطلحات موضوعية: Oncology, Hematology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::159281194542272c0e2bc7a33199eb3dTest
https://doi.org/10.1038/s41408-023-00805-xTest

المؤلفون: Yibo Lu, Qing Fang, Ming Qi, Xiaoliang Li, Xingyu Zhang, Yuwan Lin, Ying Xiang, Qihua Fu, Bo Wang

المصدر: Communications Biology. 6

مصطلحات موضوعية: Medicine (miscellaneous), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology

الوصف: Copy number variations (CNVs) have long been recognized as pathogenic factors for congenital heart disease (CHD). Few CHD associated CNVs could be interpreted as dosage effect due to disruption of coding sequences. Emerging evidences have highlighted the regulatory roles of long noncoding RNAs (lncRNAs) in cardiac development. Whereas it remains unexplored whether lncRNAs within CNVs (CNV-lncRNAs) could contribute to the etiology of CHD associated CNVs. Here we constructed coexpression networks involving CNV-lncRNAs within CHD associated CNVs and protein coding genes using the human organ developmental transcriptomic data, and showed that CNV-lncRNAs within 10 of the non-syndromic CHD associated CNVs clustered in the most significant heart correlated module, and had highly correlated coexpression with multiple key CHD genes. HSALNG0104472 within 15q11.2 region was identified as a hub CNV-lncRNA with heart-biased expression and validated experimentally. Our results indicated that HSALNG0104472 should be a main effector responsible for cardiac defects of 15q11.2 deletion through regulating cardiomyocytes differentiation. Our findings suggested that CNV-lncRNAs could potentially contribute to the pathologies of a maximum proportion of 68.4% (13/19) of non-syndromic CHD associated CNVs. These results indicated that explaining the pathogenesis of CHD associated CNVs should take account of the noncoding regions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::342275b4d3aa5284a4c039a97219f758Test
https://doi.org/10.1038/s42003-023-04565-zTest

المؤلفون: Xiangyu Wang, En-Cai Xiao, Lingcui Zhang, Yue Xu, Tong Liu, Junzhi Yi, Kaixin Song, Ze-ming Qi, Feng Shi

المصدر: Journal of Materials Science: Materials in Electronics. 33:7708-7717

مصطلحات موضوعية: Electrical and Electronic Engineering, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::dd36d6f37f6f686d2a1268e07689841eTest
https://doi.org/10.1007/s10854-022-07922-6Test