A haplotype-led approach to increase the precision of wheat breeding
| العنوان: | A haplotype-led approach to increase the precision of wheat breeding |
|---|---|
| المؤلفون: | Ricardo H. Ramirez-Gonzalez, Simon Orford, Manuel Spannagl, Jemima Brinton, Curtis J. Pozniak, James Simmonds, Sean Walkowiak, Simon Griffiths, Cristobal Uauy, Georg Haberer, Luzie U. Wingen, Wheat Genome |
| المصدر: | Comm. Biol. 3:712 (2020) Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020) Communications Biology |
| بيانات النشر: | Nature Research, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Plant genetics, Genotyping Techniques, QH301-705.5, Population, Medicine (miscellaneous), Biology, 01 natural sciences, Genome, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Genetic variation, Biology (General), education, Genotyping, Triticum, Genetic diversity, education.field_of_study, business.industry, Haplotype, Genetic Variation, food and beverages, Genomics, Biotechnology, Plant Breeding, 030104 developmental biology, Haplotypes, General Agricultural and Biological Sciences, business, Genome, Plant, 010606 plant biology & botany |
| الوصف: | Crop productivity must increase at unprecedented rates to meet the needs of the growing worldwide population. Exploiting natural variation for the genetic improvement of crops plays a central role in increasing productivity. Although current genomic technologies can be used for high-throughput identification of genetic variation, methods for efficiently exploiting this genetic potential in a targeted, systematic manner are lacking. Here, we developed a haplotype-based approach to identify genetic diversity for crop improvement using genome assemblies from 15 bread wheat (Triticum aestivum) cultivars. We used stringent criteria to identify identical-by-state haplotypes and distinguish these from near-identical sequences (~99.95% identity). We showed that each cultivar shares ~59 % of its genome with other sequenced cultivars and we detected the presence of extended haplotype blocks containing hundreds to thousands of genes across all wheat chromosomes. We found that genic sequence alone was insufficient to fully differentiate between haplotypes, as were commonly used array-based genotyping chips due to their gene centric design. We successfully used this approach for focused discovery of novel haplotypes from a landrace collection and documented their potential for trait improvement in modern bread wheat. This study provides a framework for defining and exploiting haplotypes to increase the efficiency and precision of wheat breeding towards optimising the agronomic performance of this crucial crop. Brinton, Uauy and colleagues utilize genomic data from the 10+ Wheat Genome Project to develop a useful tool for studying and generating new wheat cultivars. This framework uses advanced exploitation of wheat haplotypes to bring newfound precision and efficiency to wheat breeding. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f7b54b6f0c982678f71a0b4226ca42Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60617Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....46f7b54b6f0c982678f71a0b4226ca42 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |