Prognostic Value of Plasma hPG80 (Circulating Progastrin) in Metastatic Renal Cell Carcinoma
| العنوان: | Prognostic Value of Plasma hPG80 (Circulating Progastrin) in Metastatic Renal Cell Carcinoma |
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| المؤلفون: | Daniel Rouison, Manish Kohli, Thierry Cousin, Pierre Liaud, George Garnier, Frederic Berthier, Mélina Blairvacq, Dominique Joubert, Berengere Vire, Léa Payen, Winston Tan, Alexandre Prieur |
| المصدر: | Cancers Volume 13 Issue 3 Cancers, Vol 13, Iss 375, p 375 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, endocrine system, urologic and male genital diseases, lcsh:RC254-282, 03 medical and health sciences, Risk model, 0302 clinical medicine, Risk groups, Renal cell carcinoma, Internal medicine, medicine, IMDC, In patient, circulating progastrin, Receiver operating characteristic, business.industry, Significant difference, Area under the curve, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hPG80, Keywords: metastatic renal cell carcinoma (mRCC), 030104 developmental biology, blood-based prognostic biomarker, metastatic renal cell carcinoma (mRCC), 030220 oncology & carcinogenesis, business, Kidney cancer |
| الوصف: | Precise management of kidney cancer requires the identification of prognostic factors. hPG80 (circulating progastrin) is a tumor promoting peptide present in the blood of patients with various cancers, including renal cell carcinoma (RCC). In this study, we evaluated the prognostic value of plasma hPG80 in 143 prospectively collected patients with metastatic RCC (mRCC). The prognostic impact of hPG80 levels on overall survival (OS) in mRCC patients after controlling for hPG80 levels in non-cancer age matched controls was determined and compared to the International Metastatic Database Consortium (IMDC) risk model (good, intermediate, poor). ROC curves were used to evaluate the diagnostic accuracy of hPG80 using the area under the curve (AUC). Our results showed that plasma hPG80 was detected in 94% of mRCC patients. hPG80 levels displayed high predictive accuracy with an AUC of 0.93 and 0.84 when compared to 18&ndash 25 year old controls and 50&ndash 80 year old controls, respectively. mRCC patients with high hPG80 levels (> 4.5 pM) had significantly lower OS compared to patients with low hPG80 levels (< 4.5 pM) (12 versus 31.2 months, respectively p = 0.0031). Adding hPG80 levels (score of 1 for patients having hPG80 levels > 4.5 pM) to the six variables of the IMDC risk model showed a greater and significant difference in OS between the newly defined good-, intermediate- and poor-risk groups (p = 0.0003 compared to p = 0.0076). Finally, when patients with IMDC intermediate-risk group were further divided into two groups based on hPG80 levels within these subgroups, increased OS were observed in patients with low hPG80 levels (< 4.5 pM). In conclusion, our data suggest that hPG80 could be used for prognosticating survival in mRCC alone or integrated to the IMDC score (by adding a variable to the IMDC score or by substratifying the IMDC risk groups), be a prognostic biomarker in mRCC patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| DOI: | 10.3390/cancers13030375 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55203daeb0428300383f23a97d4db325Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....55203daeb0428300383f23a97d4db325 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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| DOI: | 10.3390/cancers13030375 |