Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children
| العنوان: | Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children |
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| المؤلفون: | Pasquale M Barbaro, Michael C.J. Quinn, Ramneek Gupta, Chelsea Mayoh, Luciano Dalla-Pozza, Glenn M. Marshall, Tamas Revesz, Francoise Mechinaud, Benjamin Ole Wolthers, Ulf Tedgård, Stuart MacGregor, Kjeld Schmiegelow, Morten Tulstrup, Pasi Huttunen, Kadri Saks, Rosemary Sutton, Frank Alvaro, Daniel Catchpoole, Georgia Chenevix-Trench, Marion K. Mateos, Olafur G. Jonsson, Toby Trahair, Draga Barbaric, Ruta Tuckuviene, Rishi S. Kotecha, Ellen Ruud, Sonata Saulyte Trakymiene, Jodie E. Giles |
| المساهمون: | HUS Comprehensive Cancer Center, HUS Children and Adolescents, Clinicum, Children's Hospital, Helsinki University Hospital Area |
| المصدر: | Cancers Volume 12 Issue 5 Cancers, Basel : MDPI, 2020, vol. 12, iss. 5, art. no. 1285, p. [1-15] Cancers, Vol 12, Iss 1285, p 1285 (2020) Mateos, M K, Tulstrup, M, Quinn, M C J, Tuckuviene, R, Marshall, G M, Gupta, R, Mayoh, C, Wolthers, B O, Barbaro, P M, Ruud, E, Sutton, R, Huttunen, P, Revesz, T, Trakymiene, S S, Barbaric, D, Tedgård, U, Giles, J E, Alvaro, F, Jonsson, O G, Mechinaud, F, Saks, K, Catchpoole, D, Kotecha, R S, Dalla-Pozza, L, Chenevix-Trench, G, Trahair, T N, Macgregor, S & Schmiegelow, K 2020, ' Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children ', Cancers, vol. 12, no. 5, 1285 . https://doi.org/10.3390/cancers12051285Test Mateos, M K, Tulstrup, M, Quinn, M C, Tuckuviene, R, Marshall, G M, Gupta, R, Mayoh, C, Wolthers, B O, Barbaro, P M, Ruud, E, Sutton, R, Huttunen, P, Revesz, T, Trakymiene, S S, Barbaric, D, Tedgård, U, Giles, J E, Alvaro, F, Jonsson, O G, Mechinaud, F, Saks, K, Catchpoole, D, Kotecha, R S, Dalla-Pozza, L, Chenevix-Trench, G, Trahair, T N, MacGregor, S & Schmiegelow, K 2020, ' Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children ', Cancers, vol. 12, no. 5, 1285 . https://doi.org/10.3390/cancers12051285Test |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, MULTICENTER, Genome-wide association study, Disease, Acute lymphoblastic leukemia, DISEASE, Coronary artery disease, 0302 clinical medicine, 3123 Gynaecology and paediatrics, GENETIC-VARIANTS, hemic and lymphatic diseases, KALIRIN, Child, Single-nucleotide polymorphism, RISK, child, CHEMOTHERAPY, single-nucleotide polymorphism, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, 030220 oncology & carcinogenesis, Meta-analysis, Cohort, Medical genetics, acute lymphoblastic leukemia, genome-wide association study, venous thromboembolism, Venous thromboembolism, medicine.medical_specialty, PEDIATRIC HEMATOLOGY, 3122 Cancers, INHIBITION, lcsh:RC254-282, Article, 03 medical and health sciences, Internal medicine, Genetic predisposition, medicine, 1112 Oncology and Carcinogenesis, business.industry, medicine.disease, INDIVIDUALS, 030104 developmental biology, business, NORDIC SOCIETY |
| الوصف: | Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We undertook a genome-wide association study (GWAS) meta-analysis for VTE in consecutively treated children in the Nordic/Baltic acute lymphoblastic leukemia 2008 (ALL2008) cohort and the Australian Evaluation of Risk of ALL Treatment-Related Side-Effects (ERASE) cohort. A total of 92 cases and 1481 controls of European ancestry were included. Results: No SNPs reached genome-wide significance (p < 5 × 10&minus 8) in either cohort. Among the top 34 single-nucleotide polymorphisms (SNPs) (p < 1 × 6), two loci had concordant effects in both cohorts: ALOX15B (rs1804772) (MAF: 1% p = 3.95 × 7) that influences arachidonic acid metabolism and thus platelet aggregation, and KALRN (rs570684) (MAF: 1% p = 4.34 × 7) that has been previously associated with risk of ischemic stroke, atherosclerosis, and early-onset coronary artery disease. Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE. |
| وصف الملف: | application/pdf; Electronic |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1e4ea3aa4cb2682ca5137ef73c7e34Test https://doi.org/10.3390/cancers12051285Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ec1e4ea3aa4cb2682ca5137ef73c7e34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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