Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
| العنوان: | Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid |
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| المؤلفون: | Zvi Vogel, Ana Juknat, Ewa Kozela |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 18, Iss 8, p 1669 (2017) |
| بيانات النشر: | MDPI, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Cannabinoid receptor, medicine.medical_treatment, Neuroregulation, Neurogenesis, Review, Cell Communication, Pharmacology, Neuroprotection, Catalysis, neuroinflammation, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, cannabidiol, 0302 clinical medicine, astrocyte, medicine, Cannabinoid receptor type 2, Animals, Humans, Physical and Theoretical Chemistry, Receptors, Cannabinoid, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Neuroinflammation, Epilepsy, Chemistry, Cannabinoids, Mental Disorders, Organic Chemistry, neurodegeneration, Neurodegenerative Diseases, General Medicine, cannabinoid, Endocannabinoid system, Computer Science Applications, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Astrocytes, Cannabinoid, Cannabidiol, 030217 neurology & neurosurgery, Biomarkers, medicine.drug |
| الوصف: | The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their precise regulation is still far from understood, although several candidate molecules/systems arise as promising targets for astrocyte-mediated neuroregulation and/or neuroprotection. The cannabinoid system and its ligands have been shown to interact and affect activities of astrocytes. Cannabidiol (CBD) is the main non-psychotomimetic cannabinoid derived from Cannabis. CBD is devoid of direct CB1 and CB2 receptor activity, but exerts a number of important effects in the brain. Here, we attempt to sum up the current findings on the effects of CBD on astrocyte activity, and in this way on central nervous system (CNS) functions, across various tested models and neuropathologies. The collected data shows that increased astrocyte activity is suppressed in the presence of CBD in models of ischemia, Alzheimer-like and Multiple-Sclerosis-like neurodegenerations, sciatic nerve injury, epilepsy, and schizophrenia. Moreover, CBD has been shown to decrease proinflammatory functions and signaling in astrocytes. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad7ead6e19fa1fe552ee6edb015d696Test http://europepmc.org/articles/PMC5578059Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bad7ead6e19fa1fe552ee6edb015d696 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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