New Targeted Therapies and Immunotherapies for Locally Advanced Periocular Malignant Tumours: Towards a New ‘Eye-Sparing’ Paradigm?
| العنوان: | New Targeted Therapies and Immunotherapies for Locally Advanced Periocular Malignant Tumours: Towards a New ‘Eye-Sparing’ Paradigm? |
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| المؤلفون: | Henri Montaudié, Sacha Nahon-Esteve, Gilles Poissonnet, Stéphanie Baillif, Corine Bertolotto, Alexandra Picard-Gauci, Lauris Gastaud, Paul Hofman, Sandra Lassalle, Arnaud Martel |
| المصدر: | Cancers Cancers, Vol 13, Iss 2822, p 2822 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Orbital exenteration, genetic structures, medicine.medical_treatment, Eye pain, Locally advanced, Review, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Medicine, orbital exenteration, eye-sparing, RC254-282, Adjuvant radiotherapy, business.industry, Treatment regimen, General surgery, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, targeted therapy, eye diseases, periocular malignant tumours, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, 030221 ophthalmology & optometry, Eyelid, sense organs, immunotherapy, business |
| الوصف: | Simple Summary Managing locally advanced periocular malignant tumours, especially those invading the orbit, is challenging. Orbital exenteration has long been considered the gold standard. The development of conservative surgical techniques in the early 2000s, followed by the emergence of new targeted therapies and immunotherapies over the past decade, has led to a paradigm shift towards the use of ‘eye-sparing’ strategies. Abstract The management of periocular skin malignant tumours is challenging. Surgery remains the mainstay of treatment for localised eyelid cancers. For more locally advanced cancers, especially those invading the orbit, orbital exenteration has long been considered the gold standard; however, it is a highly disfiguring and traumatic surgery. The last two decades have been marked by the emergence of a new paradigm shift towards the use of ‘eye-sparing’ strategies. In the early 2000s, the first step consisted of performing wide conservative eyelid and orbital excisions. Multiple flaps and grafts were needed, as well as adjuvant radiotherapy in selected cases. Although being incredibly attractive, several limitations such as the inability to treat the more posteriorly located orbital lesions, as well as unbearable diplopia, eye pain and even secondary eye loss were identified. Therefore, surgeons should distinguish ‘eye-sparing’ from ‘sight-sparing’ strategies. The second step emerged over the last decade and was based on the development of targeted therapies and immunotherapies. Their advantages include their potential ability to treat almost all tumours, regardless of their locations, without performing complex surgeries. However, several limitations have been reported, including their side effects, the appearance of primary or secondary resistances, their price and the lack of consensus on treatment regimen and exact duration. The aim of this article was to review the evolution of the management of locally advanced periocular malignant tumours over the last three decades and highlight the new paradigm shift towards the use of ‘eye-sparing’ strategies. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9865c75cca40418e8c62a2b8d265c17Test http://europepmc.org/articles/PMC8201354Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b9865c75cca40418e8c62a2b8d265c17 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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