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1
المؤلفون: Salzano, G., Rigoli, L., Valenzise, M., Chimenz, R., Passanisi, S., Lombardo, F.
المصدر: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health; Volume 19; Issue 1; Pages: 520
International Journal of Environmental Research and Public Health, Vol 19, Iss 520, p 520 (2022)مصطلحات موضوعية: Adult, Male, chronic renal failure, deafness, diabetes mellitus, DIDMOAD, genetics, optic atrophy, therapy, wolframin, Health, Toxicology and Mutagenesis, Hearing Loss, Sensorineural, Public Health, Environmental and Occupational Health, Wolfram Syndrome, Sensorineural, Article, Diabetes Mellitus, Type 1, Chronic renal failure, Deafness, Diabetes mellitus, DIDMOAD, Genetics, Optic atrophy, Therapy, Wolframin, Adult, Humans, Male, Diabetes Mellitus, Type 1, Hearing Loss, Sensorineural, Urogenital Diseases, Wolfram Syndrome, Medicine, Humans, Hearing Loss, Urogenital Diseases, Type 1
الوصف: Wolfram syndrome 1 is a rare, autosomal recessive, neurodegenerative, progressive disorder. Insulin-dependent, non-autoimmune diabetes mellitus and bilateral progressive optic atrophy are both sensitive and specific criteria for clinical diagnosis. The leading cause of death is central respiratory failure resulting from brainstem atrophy. We describe the clinical features of fourteen patients from seven different families followed in our Diabetes Center. The mean age at Wolfram syndrome 1 diagnosis was 12.4 years. Diabetes mellitus was the first clinical manifestation, in all patients. Sensorineural hearing impairment and central diabetes insipidus were present in 85.7% of patients. Other endocrine findings included hypogonadotropic hypogonadism (7.1%), hypergonadotropic hypogonadism (7.1%), and Hashimoto’s thyroiditis (21.4%). Neuropsychiatric disorders were detected in 35.7% of patients, and urogenital tract abnormalities were present in 21.4%. Finally, heart diseases were found in 14.2% of patients. Eight patients (57.1%) died at the mean age of 27.3 years. The most common cause of death was respiratory failure which occurred in six patients. The remaining two died due to end-stage renal failure and myocardial infarction. Our data are superimposable with those reported in the literature in terms of mean age of onset, the clinical course of the disease, and causes of death. The frequency of deafness and diabetes insipidus was higher in our patients. The incidence of urogenital diseases was lower although it led to the death of one patient. Long-term follow-up studies including large patient cohorts are necessary to establish potential genotype-phenotype correlation in order to personalize the most suitable clinical approach for each patient.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dba96db1d7aec1976ebd96df65da0fTest
http://europepmc.org/articles/PMC8744633Test -
2
المؤلفون: Marek Brabec, Marisa A. Nunes, Juraj Michalec, Jana Urbanová, Arian Taniwall, Matthew Campbell, Jan Brož, Ludmila Brunerová, Vojtěch Berka, Jan Polak, Denisa Janíčková Žďárská, Dario Rahelić
المصدر: Nutrients
Nutrients; Volume 13; Issue 11; Pages: 4165
Nutrients, Vol 13, Iss 4165, p 4165 (2021)مصطلحات موضوعية: Adult, Blood Glucose, Male, type 1 diabetes, Administration, Oral, Pilot Projects, Hypoglycemia, Target heart rate, Article, Heart Rate, medicine, Humans, Insulin, TX341-641, Glucose dynamics, glycemic excursion, Glycemic, Type 1 diabetes, hypoglycemia treatment, Nutrition and Dietetics, exercise, business.industry, Nutrition. Foods and food supply, medicine.disease, hypoglycemia, insulin therapy, Bicycling, Oral ingestion, Diabetes Mellitus, Type 1, Glucose, Male patient, Anesthesia, Heart rate reserve, business, Food Science
الوصف: The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88909f2618cfd27cfc3f0c751fd7766bTest
http://europepmc.org/articles/PMC8619071Test -
3
المؤلفون: Joshua Sutherland, Elina Hyppönen, Ang Zhou, Liana Najjar
المساهمون: Najjar, Liana, Sutherland, Joshua, Zhou, Ang, Hyppönen, Elina
المصدر: Nutrients
Nutrients, Vol 13, Iss 4260, p 4260 (2021)مصطلحات موضوعية: Oncology, single nucleotide, Male, Vesicular Transport Proteins, vitamin D, polymorphism, Cohort Studies, chemistry.chemical_compound, Polymorphism (computer science), TX341-641, Child, Vitamin D3 24-Hydroxylase, Nutrition and Dietetics, Vitamin D-Binding Protein, 25-hydroxyvitamin D, type 1, Meta-analysis, Child, Preschool, diabetes mellitus, Cholestanetriol 26-Monooxygenase, Female, Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor, Cohort study, Vitamin, Adult, medicine.medical_specialty, Oxidoreductases Acting on CH-CH Group Donors, Adolescent, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Amidohydrolases, Young Adult, Internal medicine, Diabetes mellitus, medicine, Vitamin D and neurology, Humans, Genetic Predisposition to Disease, Cytochrome P450 Family 2, Type 1 diabetes, Nutrition. Foods and food supply, business.industry, medicine.disease, Vitamin D Deficiency, meta-analysis, Diabetes Mellitus, Type 1, chemistry, CYP2R1, Receptors, Calcitriol, Systematic Review, business, Food Science
الوصف: Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b870821afe14962009571c35747999fTest
http://europepmc.org/articles/PMC8707565Test -
4
المؤلفون: Leszek Czupryniak, Edward Franek, Ewa Wojnar, Beata Mrozikiewicz-Rakowska, Ilona Joniec-Maciejak, Magdalena Łukawska-Tatarczuk, Dagmara Mirowska-Guzel, Agnieszka Pawlak, Jakub Zieliński
المصدر: Biomolecules
Volume 11
Issue 8
Biomolecules, Vol 11, Iss 1110, p 1110 (2021)مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, Gene Expression, Disease, 030204 cardiovascular system & hematology, Biochemistry, sirtuin 1, Carotid Intima-Media Thickness, Epigenesis, Genetic, Pathogenesis, IL-27, 0302 clinical medicine, cardiovascular disease, Euthyroid, Nicotinamide Phosphoribosyltransferase, biology, Thyroid, Middle Aged, QR1-502, medicine.anatomical_structure, female, Echocardiography, thyroid autoimmunity, Cytokines, medicine.symptom, Adult, medicine.medical_specialty, Hashimoto Disease, Microbiology, Asymptomatic, Article, 03 medical and health sciences, Internal medicine, visfatin, medicine, Humans, Molecular Biology, Type 1 diabetes, Sirtuin 1, business.industry, Interleukins, medicine.disease, Atherosclerosis, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, Premenopause, Concomitant, Case-Control Studies, biology.protein, business, type 1 diabetes mellitus
الوصف: The loss of cardioprotection observed in premenopausal, diabetic women may result from the interplay between epigenetic, metabolic, and immunological factors. The aim of this study was to evaluate the concentration of sirtuin 1, visfatin, and IL-27 in relation to cardiovascular parameters and Hashimoto’s disease (HD) in young, asymptomatic women with type 1 diabetes mellitus (T1DM). Thyroid ultrasound, carotid intima-media thickness (cIMT) measurement, electrocardiography, and echocardiography were performed in 50 euthyroid females with T1DM (28 with HD and 22 without concomitant diseases) and 30 controls. The concentrations of serum sirtuin 1, visfatin and IL-27 were assessed using ELISA. The T1DM and HD group had higher cIMT (p = 0.018) and lower left ventricular global longitudinal strain (p = 0.025) compared to females with T1DM exclusively. In women with a double diagnosis, the sirtuin 1 and IL-27 concentrations were non-significantly higher than in other groups and significantly positively correlated with each other (r = 0.445, p = 0.018) and thyroid volume (r = 0.511, p = 0.005
r = 0.482, p = 0.009, respectively) and negatively correlated with relative wall thickness (r = –0.451, p = 0.016
r = –0.387, p = 0.041, respectively). These relationships were not observed in the control group nor for the visfatin concentration. These results suggest that sirtuin 1 and IL-27 contribute to the pathogenesis of early cardiac dysfunction in women with T1DM and HD.وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f0e63e866a9962c0aad067f568adb7Test
http://europepmc.org/articles/PMC8391548Test -
5
المؤلفون: Qinyi Zhong, Wencong Lv, Robin Whittemore, Jane Dixon, Jia Guo, Jiaxin Luo
المصدر: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 18, Iss 3450, p 3450 (2021)
Volume 18
Issue 7مصطلحات موضوعية: Adult, instrument translation, China, Adolescent, Psychometrics, type 1 diabetes, Health, Toxicology and Mutagenesis, lcsh:Medicine, 030209 endocrinology & metabolism, Context (language use), Mandarin Chinese, Article, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, medicine, Humans, diabetes eating problem survey-revised, 030212 general & internal medicine, Disordered eating, context relevance, Reliability (statistics), Type 1 diabetes, lcsh:R, Public Health, Environmental and Occupational Health, psychometric property, Construct validity, Reproducibility of Results, medicine.disease, language.human_language, Test (assessment), Diabetes Mellitus, Type 1, Convergent validity, language, Psychology, Clinical psychology
الوصف: Background: People with type 1 diabetes are susceptible to disordered eating behaviors. The American Diabetes Association recommends using the Diabetes Eating Problem Survey-Revised (DEPS-R) to screen them. There is no validated diabetes-specific screening measure in China. The objectives were to adapt DEPS-R into Mandarin Chinese and to test its psychometric properties among youths and adults with type 1 diabetes in China, respectively. Methods: This study was conducted in two phases. Phase 1 included context relevance evaluation and instrument translation. Phase 2 was psychometric testing of reliability and construct validity among 89 youths (8~17 years old) and 61 adults with type 1 diabetes. Result: The Context Relevance Index and Translation Validity Index of this instrument were good. Strong internal consistency reliability correlations and convergent validity were demonstrated among youths and adults. Discussion: The Chinese version of the DEPS-R is a valid and reliable tool for screening disordered eating behaviors in Chinese youths and adults with type 1 diabetes. The Context Relevance Index is advocated to evaluate the difference between the context in which an instrument was originally developed and the target context.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd111b5a2415fcb4a8f50ca5796f729eTest
http://europepmc.org/articles/PMC8037186Test -
6
المساهمون: Universidad de Sevilla Departamento de Enfermería
المصدر: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 18, Iss 2064, p 2064 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Volume 18
Issue 4
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)مصطلحات موضوعية: Adult, Adolescent, Health, Toxicology and Mutagenesis, education, Stigma (botany), Peer influence, lcsh:Medicine, Friends, Adolescents, Peer Group, Article, Developmental psychology, Social support, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Social integration, 030225 pediatrics, medicine, Humans, Social conflict, 030212 general & internal medicine, adolescents, Child, Retrospective Studies, Type 1 diabetes, peer influence, Socialization, lcsh:R, Public Health, Environmental and Occupational Health, Role, Peer group, social support, medicine.disease, Diabetes Mellitus, Type 1, role, Psychology, type 1 diabetes mellitus, Qualitative research
الوصف: The aim of this study was to examine, through the roles of peers with regards to diabetes, the relationship between the support perceived by adolescents with diabetes and their peer-group affiliation. This is a descriptive, phenomenological and retrospective study based on a qualitative methodology. In-depth interviews with 15 people aged 18–35 with type 1 diabetes mellitus diagnosed in their childhood or adolescence were carried out. Data was analyzed through the interpretation of general discourses. Peers have considerable influence on adolescents and provide them social support from different roles. The protective role basically offers emotional support and sends reminders of different aspects of the treatment, while the indifferent role does not meddle in any aspect related to the diabetes. Both roles can foster social integration of adolescents with diabetes into the peer group. The offender role creates social conflicts through discrimination and stigma of adolescents with diabetes. These roles appear during the process of socialization of adolescents with diabetes, where commensality and situations of self-monitoring or administering insulin, key aspect of diabetes treatment, are crucial. Peer groups, depending on the role adopted, may offer support or bring a specific conflict regarding diabetes to their adolescent peer. The combination of roles that friends and peer group play with regards to diabetes will determine the degree of socialization and integration of adolescents with diabetes El APC fue parcialmente financiado con apoyo financiero para la consolidación de grupos de investigación. por la Junta de Andalucía
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e5acde913ce61570ba0ea766a1ec75Test
http://europepmc.org/articles/PMC7923757Test -
7
المصدر: Viruses
Viruses, Vol 13, Iss 2223, p 2223 (2021)
Volume 13
Issue 11مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Calcitriol, viruses, vitamin D, Asymptomatic, Gastroenterology, Microbiology, Article, Pathogenesis, Myelopathy, Immune system, immune system diseases, Virology, Internal medicine, hemic and lymphatic diseases, Tropical spastic paraparesis, Vitamin D and neurology, Prevalence, Medicine, Humans, Aged, Inflammation, Human T-lymphotropic virus 1, 25(OH)D, business.industry, virus diseases, Middle Aged, HTLV, medicine.disease, Vitamin D Deficiency, HTLV-I Infections, QR1-502, Paraparesis, Tropical Spastic, Infectious Diseases, Cross-Sectional Studies, Carrier State, Cytokines, Female, medicine.symptom, business, HAM/TSP, Asymptomatic carrier, Brazil, medicine.drug
الوصف: Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hypovitaminosis D in HTLV-1 patients and its relationship with their immune response in HTLV-infected patients and in age- and gender-matched controls at a Brazilian rehabilitation hospital. We compared vitamin D, interleukin-6 (IL-6), tumoral necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) levels across groups. Logistic regression was utilized to assess the association between hypovitaminosis D and cytokine levels. We enrolled 161 HTLV-infected subjects (129 HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 32 asymptomatic HTLV carriers) and equal number of HTLV-negative controls. We observed a significantly higher prevalence of hypovitaminosis D in patients with HAM/TSP than in HTLV asymptomatic carriers (p <
0.001), or controls (p <
0.001). HAM/TSP patients also had higher levels of IL-6 and IFN-γ than asymptomatic carriers. Patients with HAM/TSP and hypovitaminosis D had higher levels of TNF-α than asymptomatic HTLV carriers. These findings suggest hypovitaminosis D plays a role in HAM/TSP pathogenesis, and it needs to be evaluated in further studies.وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2da569c6def21f630962cf38ab161cTest
http://europepmc.org/articles/PMC8623239Test -
8
المؤلفون: Scott W. Walsh, Kellie J. Archer, Jerome F. Strauss, Marwah Al Dulaimi
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12876, p 12876 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12876مصطلحات موضوعية: Adult, QH301-705.5, Neutrophils, Pregnancy Trimester, Third, Gene Expression, Biology, Catalysis, DNA sequencing, Article, Neutrophil Activation, Preeclampsia, Dioxygenases, Inorganic Chemistry, Andrology, Transcriptome, preeclampsia, chemistry.chemical_compound, Young Adult, pregnancy, neutrophils, gene expression, DNA methylation, epigenetics, protease-activated receptor 1, Pre-Eclampsia, Pregnancy, Gene expression, medicine, Humans, Epigenetics, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, Gene, QD1-999, Spectroscopy, Gene Expression Profiling, Organic Chemistry, General Medicine, medicine.disease, Computer Science Applications, DNA-Binding Proteins, Chemistry, chemistry, Case-Control Studies, Female, DNA
الوصف: Neutrophils are activated and extensively infiltrate blood vessels in preeclamptic women. To identify genes that contribute to neutrophil activation and infiltration, we analyzed the transcriptomes of circulating neutrophils from normal pregnant and preeclamptic women. Neutrophils were collected at 30 weeks’ gestation and RNA and DNA were isolated for RNA sequencing and 5-hydroxy-methylcytosine (5-hmC) sequencing as an index of dynamic changes in neutrophil DNA methylation. Women with normal pregnancy who went on to develop mild preeclampsia at term had the most uniquely expressed genes (697) with 325 gene ontology pathways upregulated, many related to neutrophil activation and function. Women with severe preeclampsia who delivered prematurely had few pathways up- or downregulated. Cluster analysis revealed that gene expression in women with severe preeclampsia was an inverse mirror image of gene expression in normal pregnancy, while gene expression in women who developed mild preeclampsia was remarkably different from both. DNA methylation marks, key regulators of gene expression, are removed by the action of ten-eleven translocation (TET) enzymes, which oxidize 5-methylcytosines (5mCs), resulting in locus-specific reversal of DNA methylation. DNA sequencing for 5-hmC revealed no differences among the three groups. Genome-wide DNA methylation revealed extremely low levels in circulating neutrophils suggesting they are de-methylated. Collectively, these data demonstrate that neutrophil gene expression profiles can distinguish different preeclampsia phenotypes, and in the case of mild preeclampsia, alterations in gene expression occur well before clinical symptoms emerge. These findings serve as a foundation for further evaluation of neutrophil transcriptomes as biomarkers of preeclampsia phenotypes. Changes in DNA methylation in circulating neutrophils do not appear to mediate differential patterns of gene expression in either mild or severe preeclampsia.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88acef7787399a409afc15fc3309f26fTest
http://europepmc.org/articles/PMC8657979Test -
9
المؤلفون: María José Pino, Carlos Herruzo, Carmen Sánchez-Urbano
المصدر: International Journal of Environmental Research and Public Health 18(9), 4818 (2021)
International Journal of Environmental Research and Public Health, Vol 18, Iss 4818, p 4818 (2021)
Helvia. Repositorio Institucional de la Universidad de Córdoba
instname
Helvia: Repositorio Institucional de la Universidad de Córdoba
Universidad de Córdoba
International Journal of Environmental Research and Public Health
Volume 18
Issue 9مصطلحات موضوعية: Adult, Adolescent, Personality Inventory, type 1 diabetes, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Psychological intervention, 030209 endocrinology & metabolism, Sample (statistics), Disease, Personality Disorders, Article, Personality prototypes, Social group, 03 medical and health sciences, Young Adult, 0302 clinical medicine, personality prototypes, medicine, Personality, Humans, 030212 general & internal medicine, adherence, Big Five personality traits, Association (psychology), media_common, Type 1 diabetes, Public Health, Environmental and Occupational Health, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Adherence, Medicine, Psychology, Clinical psychology
الوصف: Type 1 diabetes (Dm1) is a chronic endocrine and metabolic disease that affects the whole person and requires active, decisive treatment. However, personality traits may influence a patient’s adherence to treatment guidelines. The objective of this work is firstly to identify the 3 Asendorpf personality prototypes (resilient, undercontrolled and overcontrolled) in a sample of Dm1 individuals and determine whether there are any differences in comparison with a control sample
and, secondly, to study their association with adherence to self-care guidelines using both physiological indicators (HbA1C) and self-report measures. To achieve these objectives, a descriptive cross-sectional study was carried out. The sample comprised 294 participants, of whom 104 were people with Dm1 and 190 were controls. The participants, aged between 14 and 34 years, were classified by their scores in NEO-FFI-R, according to the personality characteristics inherent to Asendorpf’s prototypes. Asendorpf’s 3 prototypical personality patterns were found both in the group of people with Dm1 and in the control sample. These patterns showed different degrees of association with adherence to self-care guidelines for this disease and with psychological health factors. Importance should therefore be attached to the personality traits and Asendorpf prototypes of people with Dm1 when proposing interventions to address medical, psychological, and behavioral aspects.وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e702e9ae0267279866c81fb8de9cbb0bTest
https://hdl.handle.net/10396/21327Test -
10
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 932, p 932 (2021)مصطلحات موضوعية: 0301 basic medicine, Adult, Apolipoprotein B, endocrine system diseases, β-cells, Review, 030204 cardiovascular system & hematology, medicine.disease_cause, Bioinformatics, Catalysis, Autoimmunity, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, calcium channels, Insulin-Secreting Cells, medicine, Humans, Physical and Theoretical Chemistry, International diabetes federation, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Inflammation, Type 1 diabetes, Apolipoprotein C-III, biology, business.industry, Organic Chemistry, apolipoprotein CIII, apoptosis, nutritional and metabolic diseases, General Medicine, medicine.disease, 3. Good health, Computer Science Applications, 030104 developmental biology, Diabetes Mellitus, Type 1, lcsh:Biology (General), lcsh:QD1-999, Diabetes Mellitus, Type 2, Gene Expression Regulation, type-1 diabetes, biology.protein, Calcium, Apolipoprotein CIII, business
الوصف: It is well known that type-2 diabetes mellitus (T2D) is increasing worldwide, but also the autoimmune form, type-1 diabetes (T1D), is affecting more people. The latest estimation from the International Diabetes Federation (IDF) is that 1.1 million children and adolescents below 20 years of age have T1D. At present, we have no primary, secondary or tertiary prevention or treatment available, although many efforts testing different strategies have been made. This review is based on the findings that apolipoprotein CIII (apoCIII) is increased in T1D and that in vitro studies revealed that healthy β-cells exposed to apoCIII became apoptotic, together with the observation that humans with higher levels of the apolipoprotein, due to mutations in the gene, are more susceptible to developing T1D. We have summarized what is known about apoCIII in relation to inflammation and autoimmunity in in vitro and in vivo studies of T1D. The aim is to highlight the need for exploring this field as we still are only seeing the top of the iceberg.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ef360306ab687ff7f1dec59a52b648Test
http://europepmc.org/articles/PMC7832341Test
