المؤلفون: Salim Ait Belkacem, Sherif Kamal, Ahmed Gab Allah Ibrahim, Ramy Kotb, Nadia Boudjerra, Xin Gao, Claudie Charbonneau, Mei Xue, Zohra Kaci, Lobna Shalaby

المصدر: Expert Review of Pharmacoeconomics & Outcomes Research. 19:693-700

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Antifungal Agents, Adolescent, Cost effectiveness, Itraconazole, Cost-Benefit Analysis, Decision Support Techniques, Immunocompromised Host, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amphotericin B, medicine, Humans, Economic analysis, Pharmacology (medical), 030212 general & internal medicine, Intensive care medicine, Treatment costs, health care economics and organizations, Aged, Aged, 80 and over, Voriconazole, business.industry, 030503 health policy & services, Health Policy, High mortality, Health Care Costs, General Medicine, Middle Aged, Treatment Outcome, chemistry, Algeria, Egypt, Female, Caspofungin, 0305 other medical science, business, Invasive Fungal Infections, medicine.drug

الوصف: Background: Invasive fungal infections (IFIs) in immunocompromised patients are associated with high mortality and treatment costs. Identifying appropriate, cost-effective treatment strateg...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8281fe8f8cb5783d8b201bcc4d9c05Test
https://doi.org/10.1080/14737167.2019.1604225Test

المؤلفون: Hai-Rong Lv, Xue-mei Lin, Li Geng, Qi Deng, Ming-Feng Zhao, Yu-ming Li

المصدر: Current Medical Research and Opinion. 34:1209-1216

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, China, medicine.medical_specialty, Antifungal Agents, Itraconazole, 030106 microbiology, Antineoplastic Agents, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Internal medicine, Amphotericin B, Epidemiology, medicine, Humans, In patient, 030212 general & internal medicine, Intensive care medicine, Aged, Retrospective Studies, Voriconazole, Hematology, business.industry, General Medicine, Middle Aged, Treatment Outcome, Invasive fungal disease, chemistry, Hematologic Neoplasms, Female, Symptom Assessment, Caspofungin, business, Invasive Fungal Infections, medicine.drug

الوصف: Empirical antifungal therapy is effective in some patients with risk factors for invasive fungal disease (IFD) who do not qualify for the EORTC/MSG criteria for IFD, but who fail to respond to anti-bacterial and anti-viral therapy.This retrospective single-center study investigated the epidemiology of IFD and empirical antifungal therapy in patients with hematological malignancies.This study recruited 893 patients with hematologic malignancies who had failed to respond to anti-bacterial and anti-viral treatment and received antifungal therapy, but not for antifungal prophylaxis. Antifungal therapy regimens included amphotericin B, voriconazole, itraconazole and caspofungin. A total of 689 patients were diagnosed with proven, probable, or possible IFD, while 159 patients did not meet the EORTC/MSG criteria for IFD diagnosis but recovered with antifungal treatment, and 45 were excluded from having IFD. Effective treatment was defined as the disappearance or resolution of clinical symptoms of IFD.Patients diagnosed with IFD underwent chemotherapy at a higher proportion, and had significantly higher neutrophil counts compared to those who did not qualify for the EORTC/MSG criteria for IFD but responded to antifungals. The mortality due to all causes within 3 months was significantly higher for patients diagnosed with proven IFD, compared with those who did not qualify for the EORTC/MSG criteria for IFD. There was no discontinuation reported due to adverse events of caspofungin.Empirical antifungal treatment could help save the lives of some patients with severe infections who are strongly suspected of having IFD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd21dda3e0ace07239a1c46345118c91Test
https://doi.org/10.1080/03007995.2017.1386167Test

المؤلفون: Guangsen Zhang, Xiao-hui Shen, Yi-Fang Yi, Yafei Yin, Hongling Peng

المصدر: Infectious Diseases. 47:104-106

مصطلحات موضوعية: Male, Microbiology (medical), Acute promyelocytic leukemia, medicine.medical_specialty, Antifungal Agents, Itraconazole, Aspergillosis, Gastroenterology, chemistry.chemical_compound, Leukemia, Promyelocytic, Acute, hemic and lymphatic diseases, Internal medicine, Amphotericin B, medicine, Humans, Voriconazole, Acute leukemia, General Immunology and Microbiology, business.industry, General Medicine, Middle Aged, bacterial infections and mycoses, medicine.disease, Radiography, Leukemia, Treatment Outcome, Infectious Diseases, chemistry, Caspofungin, business, medicine.drug

الوصف: Fungal infection is a rare complication of acute leukemia, in which a combination of voriconazole and amphotericin B is a first-line regimen of treatment. Here administration of itraconazole plus caspofungin resulted in a dramatic response in a patient with acute promyelocytic leukemia (APL).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29910c274833ef4a0cff17270c03a3aaTest
https://doi.org/10.3109/00365548.2014.968611Test

المؤلفون: Christine C. Chiou, Andreas H. Groll, Thomas J. Walsh

المصدر: Expert Opinion on Pharmacotherapy. 8:2465-2489

مصطلحات موضوعية: medicine.medical_specialty, Antifungal Agents, Itraconazole, Chemistry, Pharmaceutical, Pharmacology, law.invention, chemistry.chemical_compound, law, medicine, Humans, Pharmacology (medical), Child, Intensive care medicine, Voriconazole, Clinical pharmacology, business.industry, Age Factors, Micafungin, General Medicine, Intensive care unit, Mycoses, chemistry, Pharmacology, Clinical, Anidulafungin, Caspofungin, business, Fluconazole, medicine.drug

الوصف: Invasive fungal infections have emerged as important causes of morbidity and mortality in profoundly immunocompromised children including cancer, transplant and intensive care unit patients. Present treatment strategies for these infections are limited by toxicity, drug interactions and expense. In order to overcome these limitations, new antifungal compounds are being developed, which may improve the therapeutic armamentarium for prevention and treatment of invasive mycoses in high-risk children. This article summarizes the clinical pharmacology of established and newly developed antifungal agents, including new triazoles and echinocandins in pediatric age groups.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d1d2c56093707645ef0e41e32de6b3Test
https://doi.org/10.1517/14656566.8.15.2465Test

المؤلفون: Judith A. Smith, Debra Oladovich, Francis J. Giles, Dawn Colburn

المصدر: Hematology. 9:217-221

مصطلحات موضوعية: Antifungal Agents, Itraconazole, Context (language use), Pharmacology, Peptides, Cyclic, Substrate Specificity, Echinocandins, Lipopeptides, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Caspofungin, medicine, Humans, Idarubicin, Drug Interactions, Cytochrome P-450 CYP2C9, business.industry, Cytarabine, In vitro toxicology, Myeloid leukemia, Hematology, medicine.disease, Leukemia, Cytochrome P-450 CYP2D6, Mycoses, chemistry, Leukemia, Myeloid, Acute Disease, Aryl Hydrocarbon Hydroxylases, Peptides, business, medicine.drug

الوصف: Antifungal prophylaxis is an important component of induction therapy for patients with acute myeloid leukemia (AML). Azole antifungal agents are increasingly used in this context. In vitro assays were performed to assess whether cytochrome P450 (CYP450) enzymes were affected by combinations of cytarabine or idarubicin with itraconazole or caspofungin.The high throughput microtiter assay was used to determine whether cytarabine, idarubicin and itraconazole or caspofungin were CYP450 isoenzyme substrates, inhibitors of CYP450 isoenzymes, and to determine potential CYP450 metabolism interactions between these agents.Idarubicin is a substrate for CYP450 2D6 and 2C9. Cytarabine is a substrate of CYP450 3A4. Idarubicin inhibits CYP450 2D6, and cytarabine, itraconazole, and caspofungin inhibit CYP450 3A4. Cytarabine metabolism was significantly decreased when combined with caspofungin or itraconazole.The inhibition of cytarabine metabolism may have important clinical implications. These in vitro findings warrant investigation with in vivo pharmacokinetic studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adcfb46bc60e9e95ff6ad7283753104Test
https://doi.org/10.1080/10245330410001701585Test