Death and Survival Signals in Photodynamic Therapy
| العنوان: | Death and Survival Signals in Photodynamic Therapy |
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| المؤلفون: | Patrizia Agostinis, Michael Dewaele, Wim Martinet, Tom Verfaillie |
| المصدر: | Methods in Molecular Biology ISBN: 9781607616962 Photodynamic therapy / Gomer, Charles J. [edit.] |
| بيانات النشر: | Humana Press, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Programmed cell death, Reactive oxygen species, Chemistry, Singlet oxygen, medicine.medical_treatment, Autophagy, Photodynamic therapy, chemistry.chemical_compound, Apoptosis, Cancer cell, medicine, Cancer research, Human medicine, Signal transduction |
| الوصف: | Photodynamic therapy (PDT) is an anticancer modality utilizing the generation of singlet oxygen and other reactive oxygen species through visible light irradiation of a photosensitive dye accumulated in the cancerous tissue. Upon exposure of cancer cells to the photodynamic stress, multiple signaling cascades are concomitantly activated and depending on the subcellular location of the generated ROS and the intensity of the oxidative damage, they dictate whether cells will cope with the stress and survive or succumb and die. Different methodologies have been developed to allow the discrimination of cell death subroutines at the morphological, ultrastructural, and biochemical levels and to scrutinize signaling cascades in response to PDT. Here we describe a selection of useful techniques to characterize apoptosis and autophagy and to monitor the activation status of the MAPK- and Akt-mTOR pathways after PDT. |
| وصف الملف: | |
| ردمك: | 978-1-60761-696-2 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911301836b1086994183e0d0d82190fbTest https://doi.org/10.1007/978-1-60761-697-9_2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....911301836b1086994183e0d0d82190fb |
| قاعدة البيانات: | OpenAIRE |
| ردمك: | 9781607616962 |
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