Prenatal ethanol exposure increases ethanol intake and reduces C-fos expression in infralimbic cortex of adolescent rats
| العنوان: | Prenatal ethanol exposure increases ethanol intake and reduces C-fos expression in infralimbic cortex of adolescent rats |
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| المؤلفون: | Samanta Mabel March, Norman E. Spear, María Carolina Fabio, Ricardo Marcos Pautassi, Michael E. Nizhnikov, Juan Carlos Molina |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Elsevier Inc, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Alcohol Drinking, Adolescent, C-Fos, Clinical Biochemistry, Infralimbic cortex, Prefrontal Cortex, Ciencias de la Salud, Nucleus accumbens, Toxicology, Biochemistry, c-Fos, Article, Behavioral Neuroscience, chemistry.chemical_compound, purl.org/becyt/ford/3.3 [https], Lma, Pregnancy, Internal medicine, medicine, Animals, Rats, Wistar, Ethanol metabolism, Prefrontal cortex, Biological Psychiatry, Pharmacology, Ethanol, biology, business.industry, Ética Médica, Extinction (psychology), Rats, Associative learning, Prenatal Exposure, medicine.anatomical_structure, Endocrinology, Gene Expression Regulation, chemistry, Prenatal Exposure Delayed Effects, biology.protein, Female, purl.org/becyt/ford/3 [https], business, Proto-Oncogene Proteins c-fos |
| الوصف: | Prenatal ethanol exposure significantly increases later predisposition for alcohol intake, but the mechanisms associated with this phenomenon remain hypothetical. This study analyzed (Experiment 1) ethanol intake in adolescent inbred WKAH/Hok Wistar rats prenatally exposed to ethanol (2.0 g/kg) or vehicle, on gestational days 17–20. Subsequent Experiments (2, 3 and 4) tested several variables likely to underlie the effect of gestational ethanol on adolescent ethanol preference, including ethanol-induced locomotor activation (LMA), ethanol-induced emission of ultrasonic vocalizations (USVs) after exposure to a rough exteroceptive stimulus, and induction of the immediate early gene C-fos in brain areas associated with processing of reward stimuli and with the retrieval and extinction of associative learning. Prenatal ethanol induced a two-fold increase in ethanol intake. Adolescents exhibited significant ethanol-induced LMA, emitted more aversive than appetitive USVs, and postnatal ethanol administration significantly exacerbated the emission of USVs. These effects, however, were not affected by prenatal ethanol. Adolescents prenatally exposed to ethanol as fetuses exhibited reduced neural activity in infralimbic cortex (but not in prelimbic cortex or nucleus accumbens core or shell), an area that has been implicated in the extinction of drug-mediated associative memories. Ethanol metabolism was not affected by prenatal ethanol. Late gestational exposure to ethanol significantly heightened drinking in the adolescent offspring of an inbred rat strain. Ethanol-induced LMA and USVs were not associated with differential ethanol intake due to prenatal ethanol exposure. Prenatal ethanol, however, altered basal neural activity in the infralimbic prefrontal cortex. Future studies should analyze the functionality of medial prefrontal cortex after prenatal ethanol and its potential association with predisposition for heightened ethanol intake. Fil: Fabio, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: March, Samanta Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Molina, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University Of Binghamton; Estados Unidos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Nizhnikov, Michael. University Of Binghamton; Estados Unidos Fil: Spear, Norman E.. University Of Binghamton; Estados Unidos Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c800cd0b43d1778648e883372fcd7a93Test http://www.sciencedirect.com/science/article/pii/S0091305712003334Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c800cd0b43d1778648e883372fcd7a93 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |