Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
| العنوان: | Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities |
|---|---|
| المؤلفون: | Linton Harriss, Steven L. Taylor, Kerry L. Ivey, Jocelyn M. Choo, Robyn McDermott, Geraint B. Rogers, Lex E. X. Leong, Fintan Thompson, Fredrick M. Mobegi, Sean M. Taylor, Steven Lodewyk Wesselingh |
| المساهمون: | Mobegi, Fredrick M, Leong, Lex Ex, Thompson, Fintan, Taylor, Sean M, Harriss, Linton R, Choo, Jocelyn M, Taylor, Steven L, Wesselingh, Steve L, McDermott, Robyn, Ivey, Kerry L, Rogers, Geraint B |
| المصدر: | eLife, Vol 9 (2020) eLife |
| بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Native Hawaiian or Other Pacific Islander, indigenous health, gut microbiome, 0302 clinical medicine, Epidemiology, Global health, Biology (General), intestine flora, Microbiology and Infectious Disease, cardiometabolic disease, Population Health, General Neuroscience, risk exposures, chronic inflammatory disease, General Medicine, dysbiosis, Middle Aged, Medicine, Female, Research Article, Human, Adult, medicine.medical_specialty, QH301-705.5, Science, Population health, Biology, General Biochemistry, Genetics and Molecular Biology, Indigenous, ruminococcaceae, 03 medical and health sciences, Young Adult, Environmental health, medicine, Humans, Microbiome, Life Style, Disease burden, Aged, metagenomics, General Immunology and Microbiology, Diet, Gastrointestinal Microbiome, 030104 developmental biology, Epidemiology and Global Health, Infectious disease (medical specialty), Observational study, 030217 neurology & neurosurgery |
| الوصف: | Poor diet and lifestyle exposures are implicated in substantial global increases in non-communicable disease burden in low-income, remote, and Indigenous communities. This observational study investigated the contribution of the fecal microbiome to influence host physiology in two Indigenous communities in the Torres Strait Islands: Mer, a remote island where a traditional diet predominates, and Waiben a more accessible island with greater access to takeaway food and alcohol. Counterintuitively, disease markers were more pronounced in Mer residents. However, island-specific differences in disease risk were explained, in part, by microbiome traits. The absence of Alistipes onderdonkii, for example, significantly (p=0.014) moderated island-specific patterns of systolic blood pressure in multivariate-adjusted models. We also report mediatory relationships between traits of the fecal metagenome, disease markers, and risk exposures. Understanding how intestinal microbiome traits influence response to disease risk exposures is critical for the development of strategies that mitigate the growing burden of cardiometabolic disease in these communities. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838079e18b36df6570f4ffa71b40e977Test https://elifesciences.org/articles/58407Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....838079e18b36df6570f4ffa71b40e977 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |