Nutrient-stimulated glucagon-like peptide 1 release after body-weight loss and weight maintenance in human subjects
| العنوان: | Nutrient-stimulated glucagon-like peptide 1 release after body-weight loss and weight maintenance in human subjects |
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| المؤلفون: | M.P.G.M. Lejeune, Margriet S. Westerterp-Plantenga, Tanja C. Adam |
| المساهمون: | Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| المصدر: | British Journal of Nutrition, 95(1), 160-167. Cambridge University Press |
| بيانات النشر: | Cambridge University Press, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, media_common.quotation_subject, Appetite, Medicine (miscellaneous), Fatty Acids, Nonesterified, Peptide hormone, Body Mass Index, NEFA, Glucagon-Like Peptide 1, Weight loss, Internal medicine, Weight Loss, medicine, Humans, Insulin, Ingestion, Obesity, media_common, Nutrition and Dietetics, Chemistry, Body Weight, Area under the curve, Middle Aged, Glucagon-like peptide-1, Diet, Endocrinology, Postprandial, Adipose Tissue, Body Composition, Female, Insulin Resistance, medicine.symptom, Energy Intake, Energy Metabolism |
| الوصف: | Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released in response to nutrient ingestion. Postprandial GLP-1 release has been reported to be attenuated in obese subjects, but reports on the effect of weight loss on GLP-1 are conflicting. The aim of the present study was to clarify the effect of a weight-loss period and a consecutive weight-maintenance period on nutrient-stimulated GLP-1 release in obese subjects. Nutrient-stimulated (standard breakfast; 1.9 MJ) GLP-1 release was investigated in thirty-two obese subjects on three occasions: before weight loss (T1) (BMI 30.0 (sd 2.5) kg/m(2)); after a 6-week very-low-energy diet (VLED) (T2) (BMI 27.6 (sd 2.3) kg/m(2)); after a 3-month weight-maintenance period (T3) (BMI 27.9 (sd 2.3) kg/m(2)). At each occasion, following a fasting blood sample the test meal was fed and blood was drawn every 30 min for 2 h relative to ingestion in order to determine plasma GLP-1, insulin, glucose and NEFA concentrations. Subjects lost 7 (sd 3.4) kg during the VLED (P |
| اللغة: | English |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23979a24e0bbac0db9b2a24c634fa2aTest https://cris.maastrichtuniversity.nl/en/publications/081505f4-4cf8-4adc-bacd-bcb0a62cf6f7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e23979a24e0bbac0db9b2a24c634fa2a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
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