Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats
| العنوان: | Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats |
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| المؤلفون: | Nurcan Dursun, Eylem Taskin, Kalender Ozdogan |
| المصدر: | Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology. 11 |
| بيانات النشر: | AVES Publishing Co., 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Carnosine, Blood Pressure, medicine.disease_cause, Rats, Sprague-Dawley, Toxicology, Superoxide dismutase, Lipid peroxidation, Electrocardiography, Random Allocation, Ventricular Dysfunction, Left, chemistry.chemical_compound, Heart Rate, Internal medicine, Lactate dehydrogenase, Animals, Medicine, Aspartate Aminotransferases, Creatine Kinase, Heart Failure, chemistry.chemical_classification, Glutathione Peroxidase, Antibiotics, Antineoplastic, L-Lactate Dehydrogenase, biology, Superoxide Dismutase, business.industry, Glutathione peroxidase, Hemodynamics, Alanine Transaminase, Catalase, Malondialdehyde, Rats, Oxidative Stress, Endocrinology, chemistry, Doxorubicin, Ventricular pressure, Cardiology, biology.protein, Female, Lipid Peroxidation, Cardiology and Cardiovascular Medicine, business, Oxidative stress |
| الوصف: | Amaç: Oksidatif stres, adriamisinin (ADR) neden olduğu kardiyak fonksiyon bozukluğu patogenezinde, önemli faktörlerden birisidir. Bu çalışmadasıçanlarda adriamisin ile oluşturulan kalp hasarı üzerine karnozinin antioksidan savunma etkisi araştırılmıştır.Yöntemler: Dişi Spraque Dawley sıçanlar 4 gruba ayrıldı; kontrol (KONT, n=8, serum fizyolojik i.v.); karnozin (KAR, n=8, 10 mg/kg/gün, i.v.) sadeceadriamisin (ADR, n=10, 4 mg/kg dört defa, iki gün ara ile toplam 8 gün, i.v.); karnozin ile adriamisin (KAR+ADR, n=10). Karnozin, adriamisinden birhafta önce verilmeye başlandı ve sonraki bir hafta adriamisinle birlikte verildi. Fizyolojik fonksiyon değerlendirmelerinden sonra biyokimyasaltayinler için kan örnekleri alındı. Kalpler hemodinamik çalışma için izole edildi. Gruplar arası farklılıkların belirlenmesi için ANOVA ve posthocTukey testi kullanıldı.Bulgular: Adriamisin, belirgin bir şekilde kalp hasarı yapmış olup; karnozin ve kontrol grubuna göre, hemodinamik değişiklikler [azalmış solventrikül basınç gelişimi (p Objective: Oxidative stress is one of the major factors involved in the pathogenesis of adriamycin (ADR)-induced cardiac dysfunction. Thepresent study examined the antioxidant protective effects of carnosine (CAR) on adriamycin-induced cardiac damage in rats.Methods: Female Sprague Dawley rats were divided into four groups. Control (CONT, n=8, saline only i.v.); carnosine (CAR, n=8.10 mg/kg/day,i.v.); adriamycin (ADR, n=10.4 mg/kg four times every 2 days for 8 days, i.v.) alone and carnosine with adriamycin (CAR+ADR, n=10). Carnosinewas given one week before adriamycin treatment and following one week with adriamycin treatment. After measurement of physiological functions,blood samples were collected for biochemical assays. The hearts were excised for hemodynamic study. Comparisons between differentgroups were made using ANOVA and posthoc Tukey test.Results: Adriamycin produced evident cardiac damage revealed by; hemodynamic changes - decreased left ventricular developed pressure(p |
| تدمد: | 1308-0032 1302-8723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5335d1ced97c9108bc08307f5794f440Test https://doi.org/10.5152/akd.2011.003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5335d1ced97c9108bc08307f5794f440 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13080032 13028723 |
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