-
1
المؤلفون: Liyun Ding, Matthew P. Coghlan, Ellen P.S. Conceição Furber, Jorge Alsina-Fernandez, Kyle W. Sloop, Brian A. Droz, Mridula Dogra, Annie M. Long, Michael E. Christe, Tamer Coskun, Ruth E. Gimeno, Xiaoping Ruan, Jill A. Willency, William C. Roell, Debra L. Konkol, Adrienne K. Holland, Ricardo J. Samms, Jessica L. Friedrich, Libbey S. O’Farrell, Valentina Pirro, Over Cabrera, Daniel A. Briere, Richard Cosgrove, Samantha Wojnicki, Kyla A.L. Collins, Julie S. Moyers, Yanzhu Lin, Christine C. Cheng
المصدر: J Clin Invest
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.medical_specialty, medicine.drug_class, Adipose Tissue, White, medicine.medical_treatment, Gastric Inhibitory Polypeptide, White adipose tissue, Type 2 diabetes, Glucagon-Like Peptide-1 Receptor, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Internal medicine, Diabetes mellitus, Brown adipose tissue, medicine, Animals, Obesity, Sensitization, Mice, Knockout, business.industry, Insulin, Body Weight, General Medicine, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, 030220 oncology & carcinogenesis, Insulin Resistance, business, Amino Acids, Branched-Chain, hormones, hormone substitutes, and hormone antagonists, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4281cb2d7c4426d2de7cba245f46e9Test
https://doi.org/10.1172/jci146353Test -
2
المصدر: J Clin Invest
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Population, Type 2 diabetes, Glycemic Control, Glucagon-Like Peptide-1 Receptor, Nephropathy, Diabetes Complications, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Humans, Intensive care medicine, education, Sodium-Glucose Transporter 2 Inhibitors, Glycemic, Macrovascular disease, Heart Failure, education.field_of_study, Dipeptidyl-Peptidase IV Inhibitors, business.industry, Review Series, General Medicine, medicine.disease, Clinical trial, 030104 developmental biology, Diabetes Mellitus, Type 2, 030220 oncology & carcinogenesis, Hyperglycemia, business, Kidney disease
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affc7a610c9dce90fd1d0d00421f4376Test
https://europepmc.org/articles/PMC7810496Test/ -
3
المؤلفون: Jens J. Holst, Katrine D. Galsgaard, Johanne Agerlin Windeløv, Rainer E. Martin, Nicolai J. Wewer Albrechtsen, Jenna Hunt, Carolyn F. Deacon, Hannelouise Kissow, Thomas B. Farb, Jens Pedersen, Sara L. Jepsen
المصدر: Jepsen, S L, Albrechtsen, N J W, Windeløv, J A, Galsgaard, K D, Hunt, J E, Farb, T B, Kissow, H, Pedersen, J, Deacon, C F, Martin, R E & Holst, J J 2021, ' Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut-and GLP-1R-dependent manner ', JCI insight, vol. 6, no. 4, e143228 . https://doi.org/10.1172/jci.insight.143228Test
JCI Insight, Vol 6, Iss 4 (2021)
JCI Insightمصطلحات موضوعية: G protein–coupled receptors, Blood Glucose, Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Mice, Obese, Dipeptidyl peptidase-4 inhibitor, Carbohydrate metabolism, Glucagon-Like Peptide-1 Receptor, Mice, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Glucagon-Like Peptide 1, Internal medicine, Insulin Secretion, medicine, Animals, Hypoglycemic Agents, Insulin, Somatostatin receptor 2, Secretion, Receptors, Somatostatin, Receptor, Mice, Knockout, Glucose metabolism, Dipeptidyl-Peptidase IV Inhibitors, Somatostatin receptor, Chemistry, Diabetes, digestive, oral, and skin physiology, Antagonist, General Medicine, Mice, Inbred C57BL, Disease Models, Animal, Metabolism, 030104 developmental biology, Somatostatin, 030220 oncology & carcinogenesis, Medicine, Female, hormones, hormone substitutes, and hormone antagonists, Research Article, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eb43c6cc41cbea77339f46af6533fbTest
https://doi.org/10.1172/jci.insight.143228Test -
4
المؤلفون: Francis S. Willard, Mette M. Rosenkilde, David B. Wainscott, Guemalli R. Cardona, Shweta Urva, Jens J. Holst, Matthew P. Coghlan, Todd M. Suter, Megan E. Capozzi, Kyle W. Sloop, Jonathan D. Douros, Cynthia Stutsman, David A. D'Alessio, Aaron D. Showalter, Jonathan E. Campbell, Maria Buur Nordskov Gabe, Wijnand J.C. van der Velden, Paul J. Emmerson
المصدر: JCI Insight, Vol 5, Iss 17 (2020)
Willard, F S, Douros, J D, Gabe, M, Showalter, A D, Wainscott, D B, Suter, T M, Capozzi, M E, van der Velden, W J C, Stutsman, C, Cardona, G R, Urva, S, Emmerson, P J, Holst, J J, D'Alessio, D A, Coghlan, M P, Rosenkilde, M M, Campbell, J E & Sloop, K W 2020, ' Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist ', JCI insight, vol. 5, no. 17, 140532 . https://doi.org/10.1172/jci.insight.140532Test
JCI Insightمصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Pharmacology, ACTIVATION, Mice, 0302 clinical medicine, Functional selectivity, Insulin, Receptor, PHARMACOLOGY, AFFINITY, Mice, Knockout, geography.geographical_feature_category, GLUCAGON-LIKE PEPTIDE-1, Chemistry, Diabetes, General Medicine, Islet, beta-Arrestin 1, 030220 oncology & carcinogenesis, Medicine, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Research Article, Agonist, endocrine system, medicine.drug_class, DEPENDENT INSULINOTROPIC POLYPEPTIDE, Gastric Inhibitory Polypeptide, Therapeutics, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, Islets of Langerhans, 03 medical and health sciences, Diabetes mellitus, medicine, SERUM-PROTEIN BINDING, Animals, Hypoglycemic Agents, Glucagon-like peptide 1 receptor, geography, DULAGLUTIDE, IN-VITRO, medicine.disease, 030104 developmental biology, Mechanism of action, Metabolic control analysis, INHIBITORS, SEMAGLUTIDE
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624e5796daeef879f0b6faed814fb99cTest
https://doaj.org/article/03002ae150b14972b6d0c404574ecbbdTest -
5
المؤلفون: Reilly W. Coch, Jepchumba Koech, Megan E. Capozzi, David A. D'Alessio, Jacob B. Wait, Berit Svendsen, Andrew Gordon, Brian Finan, Jonathan E. Campbell
مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, endocrine system, medicine.medical_treatment, Carbohydrate metabolism, Glucagon, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Islets of Langerhans, Mice, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Insulin-Secreting Cells, Insulin Secretion, medicine, Animals, Homeostasis, Insulin, Mice, Knockout, Chemistry, digestive, oral, and skin physiology, General Medicine, medicine.disease, Postprandial Period, Hypoglycemia, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Postprandial, Glucose, 030220 oncology & carcinogenesis, Blood sugar regulation, Secretagogue, hormones, hormone substitutes, and hormone antagonists, Hormone, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdd97e0d29757a41b65ba5556f800f3Test
https://europepmc.org/articles/PMC6777806Test/ -
6
المؤلفون: Daniel J. Drucker, Jens J. Holst, Joel F. Habener
المصدر: Drucker, D J, Habener, J F & Holst, J J 2017, ' Discovery, characterization, and clinical development of the glucagon-like peptides ', The Journal of Clinical Investigation, vol. 127, no. 12, pp. 4217-4227 . https://doi.org/10.1172/JCI97233Test
مصطلحات موضوعية: Short Bowel Syndrome, 0301 basic medicine, endocrine system, 030209 endocrinology & metabolism, Review, Computational biology, Biology, Glucagon-Like Peptide-1 Receptor, Structure-Activity Relationship, Harrington Prize Essay, 03 medical and health sciences, 0302 clinical medicine, Glucagon-Like Peptide 1, Islet cells, Drug Discovery, Journal Article, Glucagon-Like Peptide 2, Animals, Humans, digestive, oral, and skin physiology, General Medicine, Mucosal growth, 030104 developmental biology, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, hormones, hormone substitutes, and hormone antagonists
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45525cbe7e1547e47bfa80e7cccd6f70Test
https://doi.org/10.1172/jci97233Test -
7
المؤلفون: Kenneth J. Wilkins, Bryan L. Roth, Jürgen Wess, Yinghong Cui, Lingdi Wang, Luiz Felipe Barella, Diptadip Dattaroy, Franz M. Matschinsky, Klaus H. Kaestner, Jonathan Pham, Nicolai M. Doliba, Lu Zhu, Ute Hochgeschwender
مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, endocrine system, medicine.medical_treatment, Mice, Transgenic, Carbohydrate metabolism, Glucagon, Glucagon-Like Peptide-1 Receptor, Receptors, G-Protein-Coupled, 03 medical and health sciences, Mice, 0302 clinical medicine, Insulin-Secreting Cells, Paracrine Communication, medicine, Glucose homeostasis, Animals, Humans, Hypoglycemic Agents, Insulin, Receptor, G protein-coupled receptor, Chemistry, Glucagon secretion, General Medicine, Cell biology, Disease Models, Animal, 030104 developmental biology, Glucagon-Secreting Cells, 030220 oncology & carcinogenesis, Hyperglycemia, Female, Hormone, Research Article, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264f925f605acce6cb1302cecbd67c46Test
https://europepmc.org/articles/PMC6542600Test/ -
8
المؤلفون: David A. D'Alessio, Jonathan E. Campbell
المصدر: Journal of Clinical Investigation. 127:793-795
مصطلحات موضوعية: Neurons, 0301 basic medicine, Brain, Stimulation, General Medicine, Biology, Proglucagon, Glucagon-Like Peptide-1 Receptor, Mice, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Metabolic regulation, In vivo, Drug Design, Commentary, medicine, Animals, Humans, Glucose homeostasis, Neuron, Receptor, Neuroscience, Function (biology)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1514de168fe171e7e06e1b73ffd75adaTest
https://doi.org/10.1172/jci92845Test
