التفاصيل البيبلوغرافية
العنوان:
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial
المؤلفون:
Angus, Derek C , Derde, Lennie , Al-Beidh, Farah , Annane, Djillali , Arabi, Yaseen , Beane, Abigail , Van Bentum-Puijk, Wilma , Berry, Lindsay , Bhimani, Zahra , Bonten, Marc , Bradbury, Charlotte , Brunkhorst, Frank , Buxton, Meredith , Buzgau, Adrian , Cheng, Allen C , De Jong, Menno , Detry, Michelle , Estcourt, Lise , Fitzgerald, Mark , Goossens, Herman , Green, Cameron , Haniffa, Rashan , Higgins, Alisa M , Horvat, Christopher , Hullegie, Sebastiaan J , Kruger, Peter , Lamontagne, Francois , Lawler, Patrick R , Linstrum, Kelsey , Litton, Edward , Lorenzi, Elizabeth , Marshall, John , McAuley, Daniel , McGlothin, Anna , McGuinness, Shay , McVerry, Bryan , Montgomery, Stephanie , Mouncey, Paul , Murthy, Srinivas , Nichol, Alistair , Parke, Rachael , Parker, Jane , Rowan, Kathryn , Sanil, Ashish , Santos, Marlene , Saunders, Christina , Seymour, Christopher , Turner, Anne , Van De Veerdonk, Frank , Venkatesh, Balasubramanian , Zarychanski, Ryan , Berry, Scott , Lewis, Roger J , McArthur, Colin , Webb, Steven A , Gordon, Anthony C , Writing Committee For The REMAP-CAP Investigators , Angus, Derek , Cheng, Allen , Gordon, Anthony , Lawler, Patrick , Webb, Steve , Campbell, Lewis , Forbes, Andrew , Gattas, David , Heritier, Stephane , Higgins, Lisa , Peake, Sandra , Presneill, Jeffrey , Seppelt, Ian , Trapani, Tony , Young, Paul , Bagshaw, Sean , Daneman, Nick , Ferguson, Niall , Misak, Cheryl , Hullegie, Sebastiaan , Pletz, Mathias , Rohde, Gernot , Rowan, Kathy , Alexander, Brian , Basile, Kim , Girard, Timothy , Huang, David , Vates, Jennifer , Beasley, Richard , Fowler, Robert , McGloughlin, Steve , Morpeth, Susan , Paterson, David , Venkatesh, Bala , Uyeki, Tim , Baillie, Kenneth , Duffy, Eamon , Fowler, Rob , Hills, Thomas , Orr, Katrina , Patanwala, Asad , Tong, Steve , Netea, Mihai , Bihari, Shilesh , Carrier, Marc , Fergusson, Dean , Goligher, Ewan , Haidar, Ghady , Hunt, Beverley , Kumar, Anand , Laffan, Mike , Lawless, Patrick , Lother, Sylvain , McCallum, Peter , Middeldopr, Saskia , McQuilten, Zoe , Neal, Matthew , Pasi, John , Schutgens, Roger , Stanworth, Simon , Turgeon, Alexis , Weissman, Alexandra , Adhikari, Neill , Anstey, Matthew , Brant, Emily , De Man, Angelique , Lamonagne, Francois , Masse, Marie-Helene , Udy, Andrew , Arnold, Donald , Begin, Phillipe , Charlewood, Richard , Chasse, Michael , Coyne, Mark , Cooper, Jamie , Daly, James , Gosbell, Iain , Harvala-Simmonds, Heli , Hills, Tom , MacLennan, Sheila , Menon, David , McDyer, John , Pridee, Nicole , Roberts, David , Shankar-Hari, Manu , Thomas, Helen , Tinmouth, Alan , Triulzi, Darrell , Walsh, Tim , Wood, Erica , Calfee, Carolyn , O’Kane, Cecilia , Shyamsundar, Murali , Sinha, Pratik , Thompson, Taylor , Young, Ian , Bihari, Shailesh , Hodgson, Carol , Laffey, John , McAuley, Danny , Orford, Neil , Neto, Ary , Lewis, Roger , McGlothlin, Anna , Miller, Eliza , Singh, Vanessa , Zammit, Claire , Van Bentum Puijk, Wilma , Bouwman, Wietske , Mangindaan, Yara , Parker, Lorraine , Peters, Svenja , Rietveld, Ilse , Raymakers, Kik , Ganpat, Radhika , Brillinger, Nicole , Markgraf, Rene , Ainscough, Kate , Brickell, Kathy , Anjum, Aisha , Lane, Janis-Best , Richards-Belle, Alvin , Saull, Michelle , Wiley, Daisy , Bion, Julian , Connor, Jason , Gates, Simon , Manax, Victoria , Van Der Poll, Tom , Reynolds, John , Van Beurden, Marloes , Effelaar, Evelien , Schotsman, Joost , Boyd, Craig , Harland, Cain , Shearer, Audrey , Wren, Jess , Clermont, Giles , Garrard, William , Kalchthaler, Kyle , King, Andrew , Ricketts, Daniel , Malakoutis, Salim , Marroquin, Oscar , Music, Edvin , Quinn, Kevin , Cate, Heidi , Pearson, Karen , Collins, Joanne , Hanson, Jane , Williams, Penny , Jackson, Shane , Asghar, Adeeba , Dyas, Sarah , Sutu, Mihaela , Murphy, Sheenagh , Williamson, Dawn , Mguni, Nhlanhla , Potter, Alison , Porter, David , Goodwin, Jayne , Rook, Clare , Harrison, Susie , Williams, Hannah , Campbell, Hilary , Lomme, Kaatje , Williamson, James , Sheffield, Jonathan , Van’t Hoff, Willian , McCracken, Phobe , Young, Meredith , Board, Jasmin , Mart, Emma , Knott, Cameron , Smith, Julie , Boschert, Catherine , Affleck, Julia , Ramanan, Mahesh , D’Souza, Ramsy , Pateman, Kelsey , Shakih, Arif , Cheung, Winston , Kol, Mark , Wong, Helen , Shah, Asim , Wagh, Atul , Simpson, Joanne , Duke, Graeme , Chan, Peter , Cartner, Brittney , Hunter, Stephanie , Laver, Russell , Shrestha, Tapaswi , Regli, Adrian , Pellicano, Annamaria , McCullough, James , Tallott, Mandy , Kumar, Nikhil , Panwar, Rakshit , Brinkerhoff, Gail , Koppen, Cassandra , Cazzola, Federica , Brain, Matthew , Mineall, Sarah , Fischer, Roy , Biradar, Vishwanath , Soar, Natalie , White, Hayden , Estensen, Kristen , Morrison, Lynette , Smith, Joanne , Cooper, Melanie , Health, Monash , Shehabi, Yahya , Al-Bassam, Wisam , Hulley, Amanda , Whitehead, Christina , Lowrey, Julie , Gresha, Rebecca , Walsham, James , Meyer, Jason , Harward, Meg , Venz, Ellen , Williams, Patricia , Kurenda, Catherine , Smith, Kirsy , Smith, Margaret , Garcia, Rebecca , Barge, Deborah , Byrne, Deborah , Byrne, Kathleen , Driscoll, Alana , Fortune, Louise , Janin, Pierre , Yarad, Elizabeth , Hammond, Naomi , Bass, Frances , Ashelford, Angela , Waterson, Sharon , Wedd, Steve , McNamara, Robert , Buhr, Heidi , Coles, Jennifer , Schweikert, Sacha , Wibrow, Bradley , Rauniyar, Rashmi , Myers, Erina , Fysh, Ed , Dawda, Ashlish , Mevavala, Bhaumik , Litton, Ed , Ferrier, Janet , Nair, Priya , Buscher, Hergen , Reynolds, Claire , Santamaria, John , Barbazza, Leanne , Homes, Jennifer , Smith, Roger , Murray, Lauren , Brailsford, Jane , Forbes, Loretta , Maguire, Teena , Mariappa, Vasanth , Smith, Judith , Simpson, Scott , Maiden, Matthew , Bone, Allsion , Horton, Michelle , Salerno, Tania , Sterba, Martin , Geng, Wenli , Depuydt, Pieter , De Waele, Jan , De Bus, Liesbet , Fierens, Jan , Bracke, Stephanie , Reeve, Brenda , Dechert, William , Chassé, Michaël , Carrier, François Martin , Boumahni, Dounia , Benettaib, Fatna , Ghamraoui, Ali , Bellemare, David , Cloutier, Ève , Francoeur, Charles , Lamontagne, François , D’Aragon, Frédérick , Carbonneau, Elaine , Leblond, Julie , Vazquez-Grande, Gloria , Marten, Nicole , Wilson, Maggie , Albert, Martin , Serri, Karim , Cavayas, Alexandros , Duplaix, Mathilde , Williams, Virginie , Rochwerg, Bram , Karachi, Tim , Oczkowski, Simon , Centofanti, John , Millen, Tina , Duan, Erick , Tsang, Jennifer , Patterson, Lisa , English, Shane , Watpool, Irene , Porteous, Rebecca , Miezitis, Sydney , McIntyre, Lauralyn , Brochard, Laurent , Burns, Karen , Sandhu, Gyan , Khalid, Imrana , Binnie, Alexandra , Powell, Elizabeth , McMillan, Alexandra , Luk, Tracy , Aref, Noah , Andric, Zdravko , Cviljevic, Sabina , Đimoti, Renata , Zapalac, Marija , Mirković, Gordan , Baršić, Bruno , Kutleša, Marko , Kotarski, Viktor , Vujaklija Brajković, Ana , Babel, Jakša , Sever, Helena , Dragija, Lidija , Kušan, Ira , Vaara, Suvi , Pettilä, Leena , Heinonen, Jonna , Kuitunen, Anne , Karlsson, Sari , Vahtera, Annukka , Kiiski, Heikki , Ristimäki, Sanna , Azaiz, Amine , Charron, Cyril , Godement, Mathieu , Geri, Guillaume , Vieillard-Baron, Antoine , Pourcine, Franck , Monchi, Mehran , Luis, David , Mercier, Romain , Sagnier, Anne , Verrier, Nathalie , Caplin, Cecile , Siami, Shidasp , Aparicio, Christelle , Vautier, Sarah , Jeblaoui, Asma , Fartoukh, Muriel , Courtin, Laura , Labbe, Vincent , Leparco, Cécile , Muller, Grégoire , Nay, Mai-Anh , Kamel, Toufik , Benzekri, Dalila , Jacquier, Sophie , Mercier, Emmanuelle , Chartier, Delphine , Salmon, Charlotte , Dequin, PierreFrançois , Schneider, Francis , Morel, Guillaume , L’Hotellier, Sylvie , Badie, Julio , Berdaguer, Fernando Daniel , Malfroy, Sylvain , Mezher, Chaouki , Bourgoin, Charlotte , Megarbane, Bruno , Voicu, Sebastian , Deye, Nicolas , Malissin, Isabelle , Sutterlin, Laetitia , Guitton, Christophe , Darreau, Cédric , Landais, Mickaël , Chudeau, Nicolas , Robert, Alain , Moine, Pierre , Heming, Nicholas , Maxime, Virginie , Bossard, Isabelle , Nicholier, Tiphaine Barbarin , Colin, Gwenhael , Zinzoni, Vanessa , Maquigneau, Natacham , Finn, André , Kreß, Gabriele , Hoff, Uwe , Friedrich Hinrichs, Carl , Nee, Jens , Hagel, Stefan , Ankert, Juliane , Kolanos, Steffi , Bloos, Frank , Petros, Sirak , Pasieka, Bastian , Kunz, Kevin , Appelt, Peter , Schütze, Bianka , Kluge, Stefan , Nierhaus, Axel , Jarczak, Dominik , Roedl, Kevin , Weismann, Dirk , Frey, Anna , Klinikum Neukölln, Vivantes , Reill, Lorenz , Distler, Michael , Maselli, Astrid , Bélteczki, János , Magyar, István , Fazekas, Ágnes , Kovács, Sándor , Szőke, Viktória , Szigligeti, Gábor , Leszkoven, János , Collins, Daniel , Breen, Patrick , Frohlich, Stephen , Whelan, Ruth , McNicholas, Bairbre , Scully, Michael , Casey, Siobhan , Kernan, Maeve , Doran, Peter , O’Dywer, Michael , Smyth, Michelle , Hayes, Leanne , Hoiting, Oscar , Peters, Marco , Rengers, Els , Evers, Mirjam , Prinssen, Anton , Bosch Ziekenhuis, Jeroen , Simons, Koen , Rozendaal, Wim , Polderman, F , De Jager, P , Moviat, M , Paling, A , Salet, A , Rademaker, Emma , Peters, Anna Linda , De Jonge, E , Wigbers, J , Guilder, E , Butler, M , Cowdrey, Keri-Anne , Newby, Lynette , Chen, Yan , Simmonds, Catherine , McConnochie, Rachael , Ritzema Carter, Jay , Henderson, Seton , Van Der Heyden, Kym , Mehrtens, Jan , Williams, Tony , Kazemi, Alex , Song, Rima , Lai, Vivian , Girijadevi, Dinu , Everitt, Robert , Russell, Robert , Hacking, Danielle , Buehner, Ulrike , Williams, Erin , Browne, Troy , Grimwade, Kate , Goodson, Jennifer , Keet, Owen , Callender, Owen , Martynoga, Robert , Trask, Kara , Butler, Amelia , Schischka, Livia , Young, Chelsea , Lesona, Eden , Olatunji, Shaanti , Robertson, Yvonne , José, Nuno , Amaro Dos Santos Catorze, Teodoro , De Lima Pereira, Tiago Nuno Alfaro , Neves Pessoa, Lucilia Maria , Castro Ferreira, Ricardo Manuel , Pereira Sousa Bastos, Joana Margarida , Aysel Florescu, Simin , Stanciu, Delia , Zaharia, Miahela Florentina , Kosa, Alma Gabriela , Codreanu, Daniel , Marabi, Yaseen , Al Qasim, Eman , Moneer Hagazy, Mohamned , Al Swaidan, Lolowa , Arishi, Hatim , Muñoz-Bermúdez, Rosana , Marin-Corral, Judith , Salazar Degracia, Anna , Parrilla Gómez, Francisco , Mateo López, Maria Isabel , Rodriguez Fernandez, Jorge , Cárcel Fernández, Sheila , Carmona Flores, Rosario , León López, Rafael , De La Fuente Martos, Carmen , Allan, Angela , Polgarova, Petra , Farahi, Neda , McWilliam, Stephen , Hawcutt, Daniel , Rad, Laura , O’Malley, Laura , Whitbread, Jennifer , Kelsall, Olivia , Wild, Laura , Thrush, Jessica , Wood, Hannah , Austin, Karen , Donnelly, Adrian , Kelly, Martin , O’Kane, Sinéad , McClintock, Declan , Warnock, Majella , Johnston, Paul , Gallagher, Linda Jude , Mc Goldrick, Clare , Mc Master, Moyra , Strzelecka, Anna , Jha, Rajeev , Kalogirou, Michael , Ellis, Christine , Krishnamurthy, Vinodh , Deelchand, Vashish , Silversides, Jon , McGuigan, Peter , Ward, Kathryn , O’Neill, Aisling , Finn, Stephanie , Phillips, Barbara , Mullan, Dee , Oritz-Ruiz De Gordoa, Laura , Thomas, Matthew , Sweet, Katie , Grimmer, Lisa , Johnson, Rebekah , Pinnell, Jez , Robinson, Matt , Gledhill, Lisa , Wood, Tracy , Morgan, Matt , Cole, Jade , Hill, Helen , Davies, Michelle , Antcliffe, David , Templeton, Maie , Rojo, Roceld , Coghlan, Phoebe , Smee, Joanna , Mackay, Euan , Cort, Jon , Whileman, Amanda , Spencer, Thomas , Spittle, Nick , Kasipandian, Vidya , Patel, Amit , Allibone, Suzanne , Genetu, Roman Mary , Ramali, Mohamed , Ghosh, Alison , Bamford, Peter , London, Emily , Cawley, Kathryn , Faulkner, Maria , Jeffrey, Helen , Smith, Tim , Brewer, Chris , Gregory, Jane , Limb, James , Cowton, Amanda , O’Brien, Julie , Nikitas, Nikitas , Wells, Colin , Lankester, Liana , Pulletz, Mark , Birch, Jenny , Wiseman, Sophie , Horton, Sarah , Alegria, Ana , Turki, Salah , Elsefi, Tarek , Crisp, Nikki , Allen, Louise , McCullagh, Iain , Robinson, Philip , Hays, Carole , Babio-Galan, Maite , Stevenson, Hannah , Khare, Divya , Pinder, Meredith , Selvamoni, Selvin , Gopinath, Amitha , Pugh, Richard , Menzies, Daniel , Mackay, Callum , Allan, Elizabeth , Davies, Gwyneth , Puxty, Kathryn , McCue, Claire , Cathcart, Susanne , Hickey, Naomi , Ireland, Jane , Yusuff, Hakeem , Isgro, Graziella , Brightling, Chris , Bourne, Michelle , Craner, Michelle , Watters, Malcolm , Prout, Rachel , Davies, Louisa , Pegler, Suzannah , Kyeremeh, Lynsey , Arbane, Gill , Wilson, Karen , Gomm, Linda , Francia, Federica , Brett, Stephen , Sousa Arias, Sonia , Elin Hall, Rebecca , Budd, Joanna , Small, Charlotte , Birch, Janine , Collins, Emma , Henning, Jeremy , Bonner, Stephen , Hugill, Keith , Cirstea, Emanuel , Wilkinson, Dean , Karlikowski, Michal , Sutherland, Helen , Wilhelmsen, Elva , Woods, Jane , North, Julie , Sundaran, Dhinesh , Hollos, Laszlo , Coburn, Susan , Walsh, Joanne , Turns, Margaret , Hopkins, Phil , Smith, John , Noble, Harriet , Depante, Maria Theresa , Clarey, Emma , Laha, Shondipon , Verlander, Mark , Williams, Alexandra , Huckle, Abby , Hall, Andrew , Cooke, Jill , Gardiner-Hill, Caroline , Maloney, Carolyn , Qureshi, Hafiz , Flint, Neil , Nicholson, Sarah , Southin, Sara , Nicholson, Andrew , Borgatta, Barbara , Turner-Bone, Ian , Reddy, Amie , Wilding, Laura , Chamara Warnapura, Loku , Agno Sathianathan, Ronan , Golden, David , Hart, Ciaran , Jones, Jo , Bannard-Smith, Jonathan , Henry, Joanne , Birchall, Katie , Pomeroy, Fiona , Quayle, Rachael , Makowski, Arystarch , Misztal, Beata , Ahmed, Iram , KyereDiabour, Thyra , Naiker, Kevin , Stewart, Richard , Mwaura, Esther , Mew, Louise , Wren, Lynn , Willams, Felicity , Innes, Richard , Doble, Patricia , Hutter, Joanne , Shovelton, Charmaine , Plumb, Benjamin , Szakmany, Tamas , Hamlyn, Vincent , Hawkins, Nancy , Lewis, Sarah , Dell, Amanda , Gopal, Shameer , Ganguly, Saibal , Smallwood, Andrew , Harris, Nichola , Metherell, Stella , Lazaro, Juan Martin , Newman, Tabitha , Fletcher, Simon , Nortje, Jurgens , Fottrell-Gould, Deirdre , Randell, Georgina , Zaman, Mohsin , Elmahi, Einas , Jones, Andrea , Hall, Kathryn , Mills, Gary , Ryalls, Kim , Bowler, Helen , Sall, Jas , Bourne, Richard , Borrill, Zoe , Duncan, Tracey , Lamb, Thomas , Shaw, Joanne , Fox, Claire , Moreno Cuesta, Jeronimo , Xavier, Kugan , Purohit, Dharam , Elhassan, Munzir , Bakthavatsalam, Dhanalakshmi , Rowland, Matthew , Hutton, Paula , Bashyal, Archana , Davidson, Neil , Hird, Clare , Chhablani, Manish , Phalod, Gunjan , Kirkby, Amy , Archer, Simon , Netherton, Kimberley , Reschreiter, Henrik , Camsooksai, Julie , Patch, Sarah , Jenkins, Sarah , Pogson, David , Rose, Steve , Daly, Zoe , Brimfield, Lutece , Claridge, Helen , Parekh, Dhruv , Bergin, Colin , Bates, Michelle , Dasgin, Joanne , McGhee, Christopher , Sim, Malcolm , Hay, Sophie Kennedy , Henderson, Steven , Phull, Mandeep-Kaur , Zaidi, Abbas , Pogreban, Tatiana , Rosaroso, Lace Paulyn , Harvey, Daniel , Lowe, Benjamin , Meredith, Megan , Ryan, Lucy , Hormis, Anil , Walker, Rachel , Collier, Dawn , Kimpton, Sarah , Oakley, Susan , Rooney, Kevin , Rodden, Natalie , Hughes, Emma , Thomson, Nicola , McGlynn, Deborah , Walden, Andrew , Jacques, Nicola , Coles, Holly , Tilney, Emma , Vowell, Emma , Schuster-Bruce, Martin , Pitts, Sally , Miln, Rebecca , Purandare, Laura , Vamplew, Luke , Spivey, Michael , Bean, Sarah , Burt, Karen , Moore, Lorraine , Day, Christopher , Gibson, Charly , Gordon, Elizabeth , Zitter, Letizia , Keenan, Samantha , Baker, Evelyn , Cherian, Shiney , Cutler, Sean , Roynon-Reed, Anna , Harrington, Kate , Raithatha, Ajay , Bauchmuller, Kris , Ahmad, Norfaizan , Grecu, Irina , Trodd, Dawn , Martin, Jane , Wrey Brown, Caroline , Arias, Ana-Marie , Craven, Thomas , Hope, David , Singleton, Jo , Clark, Sarah , Rae, Nicola , Welters, Ingeborg , Hamilton, David Oliver , Williams, Karen , Waugh, Victoria , Shaw, David , Puthucheary, Zudin , Martin, Timothy , Santos, Filipa , Uddin, Ruzena , Somerville, Alastair , Tatham, Kate Colette , Jhanji, Shaman , Black, Ethel , Dela Rosa, Arnold , Howle, Ryan , Tully, Redmond , Drummond, Andrew , Dearden, Joy , Philbin, Jennifer , Munt, Sheila , Vuylsteke, Alain , Chan, Charles , Victor, Saji , Matsa, Ramprasad , Gellamucho, Minerva , Creagh-Brown, Ben , Tooley, Joe , Montague, Laura , De Beaux, Fiona , Bullman, Laetitia , Kersiake, Ian , Demetriou, Carrie , Mitchard, Sarah , Ramos, Lidia , White, Katie , Donnison, Phil , Johns, Maggie , Casey, Ruth , Mattocks, Lehentha , Salisbury, Sarah , Dark, Paul , Claxton, Andrew , McLachlan, Danielle , Slevin, Kathryn , Lee, Stephanie , Hulme, Jonathan , Joseph, Sibet , Kinney, Fiona , Senya, Ho Jan , Oborska, Aneta , Kayani, Abdul , Hadebe, Bernard , Orath Prabakaran, Rajalakshmi , Nichols, Lesley , Thomas, Matt , Worner, Ruth , Faulkner, Beverley , Gendall, Emma , Hayes, Kati , Hamilton-Davies, Colin , Chan, Carmen , Mfuko, Celina , Abbass, Hakam , Mandadapu, Vineela , Leaver, Susannah , Forton, Daniel , Patel, Kamal , Paramasivam, Elankumaran , Powell, Matthew , Gould, Richard , Wilby, Elizabeth , Howcroft, Clare , Banach, Dorota , Fernández De Pinedo Artaraz, Ziortza , Cabreros, Leilani , White, Ian , Croft, Maria , Holland, Nicky , Pereira, Rita , Zaki, Ahmed , Johnson, David , Jackson, Matthew , Garrard, Hywel , Juhaz, Vera , Roy, Alistair , Rostron, Anthony , Woods, Lindsey , Cornell, Sarah , Pillai, Suresh , Harford, Rachel , Rees, Tabitha , Ivatt, Helen , Sundara Raman, Ajay , Davey, Miriam , Lee, Kelvin , Barber, Russell , Chablani, Manish , Brohi, Farooq , Jagannathan, Vijay , Clark, Michele , Purvis, Sarah , Wetherill, Bill , Dushianthan, Ahilanandan , Cusack, Rebecca , De Courcy-Golder, Kim , Smith, Simon , Jackson, Susan , Attwood, Ben , Parsons, Penny , Page, Valerie , Zhao, Xiao Bei , Oza, Deepali , Rhodes, Jonathan , Anderson, Tom , Morris, Sheila , Xia Le Tai, Charlotte , Thomas, Amy , Keen, Alexandra , Digby, Stephen , Cowley, Nicholas , Southern, David , Reddy, Harsha , Campbell, Andy , Watkins, Claire , Smuts, Sara , Touma, Omar , Barnes, Nicky , Alexander, Peter , Felton, Tim , Ferguson, Susan , Sellers, Katharine , Bradley-Potts, Joanne , Yates, David , Birkinshaw, Isobel , Kell, Kay , Marshall, Nicola , Carr-Knott, Lisa
بيانات النشر:
American Medical Association
مصطلحات موضوعية:
2. Zero hunger , Adult , Male , Hydrocortisone , SARS-CoV-2 , Pneumonia, Viral , Anti-Inflammatory Agents , COVID-19 , Shock , Middle Aged , Respiration, Artificial , 3. Good health , Betacoronavirus , Intensive Care Units , Treatment Outcome , Adrenal Cortex Hormones , Early Termination of Clinical Trials , Humans , Female , Coronavirus Infections , Pandemics
الوصف:
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707.
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b9ad2bf85fbc114516f2bda974c45ebTest
رقم الانضمام:
edsair.doi...........4b9ad2bf85fbc114516f2bda974c45eb
قاعدة البيانات:
OpenAIRE
