The gut microbiome in microscopic polyangiitis with kidney involvement: common and unique alterations, clinical association and values for disease diagnosis and outcome prediction
| العنوان: | The gut microbiome in microscopic polyangiitis with kidney involvement: common and unique alterations, clinical association and values for disease diagnosis and outcome prediction |
|---|---|
| المؤلفون: | Huan Chen, Yanhong Ma, Lini Jin, Yunting Ma, Binfeng Yu, Wanyun Nie, Zhouwei Chen, Yawen Wu, Liangliang Chen, Fei Han, Jianghua Chen |
| المصدر: | Ann Transl Med |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Autoimmune disease, Kidney, Streptococcus, medicine.medical_treatment, Physiology, General Medicine, Biology, 16S ribosomal RNA, medicine.disease, medicine.disease_cause, medicine.anatomical_structure, medicine, Original Article, Microscopic polyangiitis, Dialysis, Feces, Ruminococcaceae |
| الوصف: | BACKGROUND: Microscopic polyangiitis (MPA) is an autoimmune disease characterized by frequent kidney involvement. Imbalance of intestinal flora has been found implicated in multiple immune-mediated disorders. However, the profiling and the role of the gut microbiome in MPA remains unclear. METHODS: We performed 16S rRNA amplicon sequencing on fecal samples from 71 MPA patients with kidney involvement (35 at incipient active stage, 36 at remissive stage) and 34 healthy controls (HCs). Microbial diversity and abundance were compared among the three cohorts. The correlation between altered microbes and clinical indices were investigated. Two random forest models based on the profiling of the gut microbiome were constructed for the diagnosis of MPA. RESULTS: Two α-diversity indices, including Simpson and Shannon index, were decreased in MPA patients (P |
| تدمد: | 2305-5847 2305-5839 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320778d28effeaac9632a7f9894a77d5Test https://doi.org/10.21037/atm-21-1315Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....320778d28effeaac9632a7f9894a77d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23055847 23055839 |
|---|