نتائج البحث

1

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

مصطلحات موضوعية: Male, Oncogene Proteins, Fusion, medicine.medical_treatment, General Physics and Astronomy, Targeted therapy, Mice, 0302 clinical medicine, RNA interference, Leukaemia, MCL1, Precision Medicine, Child, 0303 health sciences, Acute leukemia, Multidisciplinary, Precursor Cell Lymphoblastic Leukemia-Lymphoma, ddc, 3. Good health, Leukemia, Myeloid, Acute, 030220 oncology & carcinogenesis, Female, Functional genomics, Myeloid-Lymphoid Leukemia Protein, Adult, Article, Cancer models, Genetic engineering, Science, Antineoplastic Agents, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, In vivo, medicine, Biomarkers, Tumor, Gene silencing, Animals, Humans, ddc:610, Gene Silencing, 030304 developmental biology, Adaptor Proteins, Signal Transducing, Homeodomain Proteins, General Chemistry, Xenograft Model Antitumor Assays, Reverse genetics, Reverse Genetics, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein

وصف الملف: application/octet-stream; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c108a41db88aecd0352ded6d797fe0aTest
https://doaj.org/article/6e797a213a574904a9cff02ded829844Test

2

Evolution of adrenoleukodystrophy model systems

المؤلفون: Roberto Montoro, Marc Engelen, Vivi M. Heine, Stephan Kemp

المصدر: Journal of Inherited Metabolic Disease
Montoro, R, Heine, V M, Kemp, S & Engelen, M 2021, ' Evolution of Adrenoleukodystrophy Model Systems ', Journal of Inherited Metabolic Disease, vol. 44, no. 3, pp. 544-553 . https://doi.org/10.1002/jimd.12357Test
Montoro, R, Heine, V M, Kemp, S & Engelen, M 2021, ' Evolution of adrenoleukodystrophy model systems ', Journal of Inherited Metabolic Disease, vol. 44, no. 3, pp. 544-553 . https://doi.org/10.1002/jimd.12357Test

مصطلحات موضوعية: Adult, Male, endocrine system, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system diseases, Model system, Disease, Review Article, Bioinformatics, ATP Binding Cassette Transporter, Subfamily D, Member 1, Models, Biological, fatty acids, Spinal Cord Diseases, model systems, 03 medical and health sciences, Myelopathy, Sex Factors, Genetics, Adrenal insufficiency, medicine, inborn error of metabolism, Animals, Humans, Adrenoleukodystrophy, Review Articles, Genetics (clinical), 030304 developmental biology, 0303 health sciences, business.industry, Cerebral white matter, pathogenesis, 030305 genetics & heredity, nutritional and metabolic diseases, peroxisomes, medicine.disease, Biological Evolution, Inborn error of metabolism, Male patient, Models, Animal, Mutation, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635c2b2666bf3f1af4547719284a6590Test
https://doi.org/10.1002/jimd.12357Test

3

Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review

المؤلفون: Caroline Vinit, Sophie Georgin-Lavialle, Aikaterini Theodoropoulou, Catherine Barbier, Alexandre Belot, Manel Mejbri, Pascal Pillet, Jana Pachlopnik, Sylvaine Poignant, Charlotte Rebelle, Andreas Woerner, Isabelle Koné-Paut, Véronique Hentgen

المساهمون: Centre Hospitalier de Versailles André Mignot (CHV), Service de Médecine Interne [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Lausanne University Hospital, Centre Hospitalier Universitaire [Grenoble] (CHU), Service de néphrologie, rhumatologie et dermatologie pédiatriques [Hôpital Femme Mère Enfant, HCL], Hospices Civils de Lyon (HCL)-Hôpital Mère Enfant, CHU Bordeaux [Bordeaux], Département de pédiatrie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU de Bordeaux Pellegrin [Bordeaux], University Children’s Hospital Basel = Hôpital pédiatrique universitaire des deux Bâle [Bâle, Suisse] (UKBB), Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre

المصدر: Frontiers in Immunology, Vol 12 (2021)
Frontiers in immunology, vol. 12, pp. 744780
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2021, 12, ⟨10.3389/fimmu.2021.744780⟩

مصطلحات موضوعية: Male, Familial Mediterranean fever, interleukin-1 blockers, Adolescent, Adult, Aged, Antibodies, Monoclonal, Humanized/therapeutic use, Antirheumatic Agents/therapeutic use, Child, Child, Preschool, Female, Hereditary Autoinflammatory Diseases/complications, Hereditary Autoinflammatory Diseases/drug therapy, Humans, Infant, Interleukin 1 Receptor Antagonist Protein/therapeutic use, Interleukin-1/antagonists & inhibitors, Middle Aged, Retrospective Studies, Young Adult, anakinra, autoinflammatory diseases, canakinumab, hereditary recurrent fevers, indications, treatment, 0302 clinical medicine, Quality of life, Immunology and Allergy, Original Research, 0303 health sciences, Mevalonate kinase deficiency, Interleukin, 3. Good health, Antirheumatic Agents, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.drug, medicine.medical_specialty, Immunology, MEDLINE, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Internal medicine, medicine, 030304 developmental biology, 030203 arthritis & rheumatology, Anakinra, business.industry, Hereditary Autoinflammatory Diseases, RC581-607, medicine.disease, Canakinumab, Interleukin 1 Receptor Antagonist Protein, Immunologic diseases. Allergy, Complication, business, Interleukin-1

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e625e3774c42c4cbcb268ba3e8a594dTest
https://www.frontiersin.org/articles/10.3389/fimmu.2021.744780/fullTest

4

Prognostic significance of genome-wide DNA methylation profiles within the randomized, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma

المساهمون: Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service d’Oncologie Médicale [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Neurology, Cell biology, Pathology, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie

المصدر: Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2021, 23 (9), pp.1547-1559. ⟨10.1093/neuonc/noab088⟩
Neuro-Oncology, 23(9), 1547-1559. Oxford University Press
Neuro-oncology, Vol. xx, no.xx, p. xx (2021)
Neuro-Oncology, 2021, 23 (9), pp.1547-1559. ⟨10.1093/neuonc/noab088⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neuro-oncology, 23(9), 1547-1559. Oxford University Press

مصطلحات موضوعية: Oncology, Cancer Research, ASTROCYTOMAS, [SDV]Life Sciences [q-bio], ESTUDOS PROSPECTIVOS, 1p/19q non-codeleted, 0302 clinical medicine, CDKN2A, Clinical endpoint, anaplastic glioma, Prospective Studies, Sequence Deletion, 0303 health sciences, Brain Neoplasms, Homozygote, Glioma, Prognosis, Isocitrate Dehydrogenase, 3. Good health, patient prognostication, GRADE, Chromosomes, Human, Pair 1, DNA methylation, SURVIVAL, DNA methylation profiling, IDH1, Life Sciences & Biomedicine, medicine.drug, Adult, medicine.medical_specialty, DNA Copy Number Variations, Clinical Neurology, Clinical Investigations, IDH mutant, CLASSIFICATION, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, medicine, AcademicSubjects/MED00300, Humans, 030304 developmental biology, Temozolomide, Science & Technology, Proportional hazards model, business.industry, CENTRAL-NERVOUS-SYSTEM, DNA Methylation, medicine.disease, Mutation, AcademicSubjects/MED00310, Neurology (clinical), Neurosciences & Neurology, business, 030217 neurology & neurosurgery, Anaplastic astrocytoma

وصف الملف: application/pdf; Print

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e028f0c3a1383a4e27bee5fc95e42bTest
http://europepmc.org/articles/PMC8408862Test

5

Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients

المؤلفون: William Rodin, Filip Ahlmanner, Elinor Bexe Lindskog, Yvonne Wettergren, Louis Szeponik, Kamil Kajetan Zajt, Marianne Quiding Järbrink, Patrik Sundström

المصدر: Cancer Immunology, Immunotherapy

مصطلحات موضوعية: Adult, Male, Cancer Research, Exhaustion, Immunology, Programmed Cell Death 1 Receptor, Tim-3, Lymphocyte Activation, Mucosal-Associated Invariant T Cells, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, Immunity, Antigens, CD, Blocking antibody, PD-1, medicine, Tumor Microenvironment, Immunology and Allergy, Cytotoxic T cell, Humans, Secretion, Hepatitis A Virus Cellular Receptor 2, MAIT cell, 030304 developmental biology, Aged, Cell Proliferation, Aged, 80 and over, 0303 health sciences, Tumor microenvironment, CD39, medicine.diagnostic_test, Effector, Chemistry, Apyrase, Middle Aged, Colorectal cancer, In vitro, Phenotype, Oncology, Colonic Neoplasms, Cancer research, Cytokines, Original Article, Female, Biomarkers, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8846e11fd7e69e73f9cd68dd02080acTest
http://europepmc.org/articles/PMC8571139Test

6

Human leukocyte antigen I is significantly downregulated in patients with myxoid liposarcomas

المؤلفون: Masanori Hayashi, Tetsuro Yamagishi, Chihaya Imai, Hajime Umezu, Takashi Ariizumi, Yudai Murayama, Akira Ogose, Naoki Oike, Hiroyuki Kawashima, Hiroshi Hatano, Naoto Endo

المصدر: Cancer Immunology, Immunotherapy

مصطلحات موضوعية: Male, Cancer Research, Pathology, medicine.medical_treatment, Liposarcomas, B7-H1 Antigen, 0302 clinical medicine, HLA Antigens, Tumor Microenvironment, Immunology and Allergy, Programmed death ligand 1, Aged, 80 and over, 0303 health sciences, Middle Aged, Prognosis, Immunohistochemistry, Liposarcoma, Myxoid, Progression-Free Survival, Oncology, 030220 oncology & carcinogenesis, Original Article, Female, Human leukocyte antigen I, Adult, medicine.medical_specialty, Adolescent, Tumor immune microenvironment, Immunology, Down-Regulation, Human leukocyte antigen, Liposarcoma, Pleomorphic Liposarcoma, 03 medical and health sciences, Young Adult, Lymphocytes, Tumor-Infiltrating, medicine, Humans, neoplasms, 030304 developmental biology, Aged, Myxoid liposarcoma, Tumor-infiltrating lymphocytes, business.industry, Macrophages, Histocompatibility Antigens Class I, Immunotherapy, medicine.disease, body regions, CD163+ macrophages, business, CD163

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80679c1ba2c44a0ce4ca344ffcd402aeTest
http://europepmc.org/articles/PMC8571150Test

7

Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections

المؤلفون: Iivari Kleino, Saila Laakso, Hannamari Välimaa, Outi Mäkitie, T. Petteri Arstila, Iivo Hetemäki, Eliisa Kekäläinen

المساهمون: Department of Bacteriology and Immunology, TRIMM - Translational Immunology Research Program, Research Programs Unit, Clinicum, HUS Children and Adolescents, Medicum, Children's Hospital, Department of Virology, HUSLAB, Oral and Maxillofacial Surgery, Helsinki University Hospital Area, Lastentautien yksikkö, Petteri Arstila / Principal Investigator

المصدر: Clinical Immunology (Orlando, Fla.)

مصطلحات موضوعية: Male, Herpesvirus 3, Human, Herpes zoster, CHRONIC MUCOCUTANEOUS CANDIDIASIS, medicine.disease_cause, Cohort Studies, APS-1, autoimmune polyendocrine syndrome type 1, Varicella zoster, 0302 clinical medicine, Autoantibody, Interferon, Risk Factors, Immunology and Allergy, Medicine, Chronic mucocutaneous candidiasis, Child, Polyendocrinopathies, Autoimmune, Immunodeficiency, 0303 health sciences, Immunity, Cellular, biology, Middle Aged, 3. Good health, 030220 oncology & carcinogenesis, Female, Antibody, medicine.drug, Adult, Herpes simplex, Adolescent, Immunology, VZV, varicella zoster virus, 03 medical and health sciences, Young Adult, Immune system, AIRE, Full Length Article, Humans, IFN, interferon, Type I interferon, 030304 developmental biology, Aged, business.industry, Varicella zoster virus, Interferon-alpha, VARICELLA, medicine.disease, PREVENTION, Autoimmune polyendocrine syndrome type 1, Varicella Zoster Virus Infection, biology.protein, HSV, herpes simplex virus, AUTOANTIBODIES, 3111 Biomedicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff03828487759ffed1d4a83e19796b0fTest
http://hdl.handle.net/10138/336743Test

8

MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes

المؤلفون: Christian Boitard, Léo Bertrand, Camille Rousseau, Pauline Soulard, Isabelle Nel, Etienne Larger, Agnès Lehuen, Matthieu Rouland, Lucie Beaudoin, Zouriatou Gouda

المساهمون: Institut Cochin, Inserm, CNRS, Laboratory of Excellence Inflamex, Université de Paris, Paris, France, Diabetology Department, Cochin Hospital, AP-HP Centre - Université de Paris, Paris, France, ROULAND, Matthieu

المصدر: Diabetologia
Diabetologia, Springer Verlag, 2021, 64 (10), pp.2306-2321. ⟨10.1007/s00125-021-05527-y⟩

مصطلحات موضوعية: Antigens, Differentiation, T-Lymphocyte, Male, Granzyme B production, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Programmed Cell Death 1 Receptor, Blood Donors, Autoimmunity, medicine.disease_cause, 0302 clinical medicine, Glucose homeostasis, IL-2 receptor, ComputingMilieux_MISCELLANEOUS, Innate immunity, 0303 health sciences, Middle Aged, Flow Cytometry, 3. Good health, [SDV] Life Sciences [q-bio], Phenotype, Type 1 diabetes, Cytokine, Proto-Oncogene Proteins c-bcl-2, Cytokines, Female, Human, Adult, MAIT cells, Mucosal-Associated Invariant T Cells, Article, Young Adult, 03 medical and health sciences, Antigens, CD, Internal Medicine, medicine, Humans, Lectins, C-Type, Interleukin-7 receptor, Aged, 030304 developmental biology, Granzyme, Autoimmune disease, business.industry, Interleukin-2 Receptor alpha Subunit, medicine.disease, Diabetes Mellitus, Type 1, Immunology, business, Biomarkers, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f472b09f7f8af8edd6dddf782a029eTest
https://hal.archives-ouvertes.fr/hal-03448807Test

9

Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

المؤلفون: Kimmo Porthan, Hannele Yki-Järvinen, Marju Orho-Melander, Panu K. Luukkonen, Sami Qadri, Anne K. Penttilä, Amalia Gastaldelli, Jussi Pihlajamäki, Henna Sammalkorpi, Anne Juuti, Ville Männistö, Melania Gaggini, Johanna Arola, A. Hakkarainen, Mika Ala-Korpela, Noora Ahlholm, Leanne Hodson, Tiina Lehtimäki

المساهمون: Yale University, University of Helsinki, University of Eastern Finland, Department of Neuroscience and Biomedical Engineering, National Research Council of Italy, University of Oulu, Lund University, University of Oxford, Aalto-yliopisto, Aalto University, Clinicum, HUS Internal Medicine and Rehabilitation, Department of Medicine, Kardiologian yksikkö, HUS Heart and Lung Center, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, Department of Pathology, HUSLAB

مصطلحات موضوعية: Male, Hepatic mitochondrial redox state, Biopsy, Mboat7, Pnpla3, Hsd17b13, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, Non-alcoholic Fatty Liver Disease, Risk Factors, insulin resistance, Marc1, Finland, De novo lipogenesis, 0303 health sciences, Fatty liver, Middle Aged, metabolomics, Adipose tissue lipolysis, 3. Good health, Liver, Lipogenesis, Female, 030211 gastroenterology & hepatology, adipose tissue lipolysis, Adult, medicine.medical_specialty, TM6SF2, HSD17B13, MBOAT7, 03 medical and health sciences, NEFA, Insulin resistance, Metabolic Diseases, Internal medicine, medicine, Humans, Metabolomics, Obesity, PNPLA3, 030304 developmental biology, Tm6sf2, Hepatology, Triglyceride, hepatic mitochondrial redox state, MARC1, medicine.disease, Mitochondrial amidoxime reducing component 1, Endocrinology, de novo lipogenesis, chemistry, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b1234c3153825c13c260807f3846a9Test
https://aaltodoc.aalto.fi/handle/123456789/113033Test

10

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study

المساهمون: Medicum, HUS Abdominal Center, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, University of Helsinki, Nefrologian yksikkö, HUS Internal Medicine and Rehabilitation, Institute for Molecular Medicine Finland, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator

المصدر: Smyth, L, Kilner, J, Nair, V, Liu, H, Brennan, E P, Kerr, K, Sandholm, N, Cole, J B, Dahlström, E, Syreeni, A, Salem, R M, Nelson, R, Looker, H, Wooster, C, Anderson, K, McKay, G, Kee, F, Young, I, Andrews, D, Forsblom, C, Hirschhorn, J N, Godson, C, Groop, P-H, Maxwell, P, Susztak, K, Kretzler, M, Florez, J C & McKnight, A J 2021, ' Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study ', Clinical Epigenetics . https://doi.org/10.1186/s13148-021-01081-xTest
Clinical epigenetics, vol 13, iss 1
Clinical Epigenetics

مصطلحات موضوعية: Male, Epigenomics, Kidney Disease, Disease, Kidney, Epigenesis, Genetic, Kidney Failure, 0302 clinical medicine, 2.1 Biological and endogenous factors, Diabetic Nephropathies, Chronic, Aetiology, end-stage, Genetics (clinical), Genetics, 0303 health sciences, Diabetes, Methylation, 3. Good health, CpG site, 030220 oncology & carcinogenesis, DNA methylation, Female, Type 1, Biotechnology, Adult, Clinical Sciences, Renal and urogenital, Biology, Autoimmune Disease, Nephropathy, Paediatrics and Reproductive Medicine, Association, 03 medical and health sciences, Genetic, SDG 3 - Good Health and Well-being, Clinical Research, medicine, Diabetes Mellitus, Humans, Epigenetics, Molecular Biology, Metabolic and endocrine, 030304 developmental biology, Research, Human Genome, End-stage, DNA Methylation, medicine.disease, Human genetics, Diabetes Mellitus, Type 1, Good Health and Well Being, 3121 General medicine, internal medicine and other clinical medicine, Kidney Failure, Chronic, EPIC, Developmental Biology, Kidney disease, Epigenesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c940c89128da9dc72b4b594c97e7b214Test
https://pure.qub.ac.uk/en/publications/assessment-of-differentially-methylated-loci-in-individuals-with-endstage-kidney-disease-attributed-to-diabetic-kidney-disease-an-exploratory-studyTest(27d453d0-b28a-4ee8-a296-df395454fc35).html

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