The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city
| العنوان: | The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city |
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| المؤلفون: | Yonghuai Li, Xihai Xu, Guanghe Fei, Aihui Xu, Xiaobo Wang, Jun Tu, Guangbo Qu, Hong Zhang, Xiao Jiang, Shiqi Zhang |
| المصدر: | Reproductive Toxicology (Elmsford, N.y.) Reproductive Toxicology |
| بيانات النشر: | Published by Elsevier Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Bodily Secretions, China, medicine.medical_specialty, Sexual transmission, Coronavirus disease 2019 (COVID-19), viruses, 010501 environmental sciences, Antibodies, Viral, Toxicology, medicine.disease_cause, expressed prostatic secretion, 01 natural sciences, Gastroenterology, Article, COVID-19 Serological Testing, 03 medical and health sciences, Prostate, Internal medicine, medicine, Humans, Secretion, skin and connective tissue diseases, Aged, 030304 developmental biology, 0105 earth and related environmental sciences, Coronavirus, 0303 health sciences, prostate, medicine.diagnostic_test, business.industry, SARS-CoV-2, fungi, RNA, COVID-19, Middle Aged, respiratory tract diseases, body regions, medicine.anatomical_structure, Immunoglobulin M, COVID-19 Nucleic Acid Testing, Immunoglobulin G, Erythrocyte sedimentation rate, Angiotensin-converting enzyme 2, RNA, Viral, Inflammation Mediators, business |
| الوصف: | Highlights • The COVID-19 patients had negative SARS-COV-2 RNA in EPS. • Serum SARS-CoV-2 IgM was positive in patients with positive pharyngeal RNA. • The inflammatory indictors were all elevated in COVID-19 patients. Due to the cellular entry of the novel coronavirus (SARS-CoV-2) modulated by angiotensin converting enzyme 2 (ACE2), the ACE2 bearing prostate is therefore hypothesized as a susceptible organ to COVID-19. To delineate whether the pathogenic SARS-CoV-2 of the coronavirus disease (COVID-19) could be detected in the expressed prostatic secretion (EPS), a total of ten male patients with confirmed COVID-19 were recruited. All patients were stratified into two groups: one group with positive nasopharyngeal swabbing SARS-CoV-2 within 3 days of the EPS taken day (PNS group, n = 3) and the other group with previously positive nasopharyngeal swabbing SARS-CoV-2 but turned negative before the taken day (PNNS group, n = 7). The COVID-19 patients showed elevated inflammatory indictors, i.e. C-reaction protein (3.28 (1.14, 33.33) mg/L), erythrocyte sedimentation rate (22.50 (8.00, 78.50) mm/h), and interleukin-6 (6.49 (4.96, 21.09) pg/ml). Serum IgM against SARS-CoV-2 was only positive in the PNS group, whereas serum IgG was positive for all patients. Furthermore, our data showed for the first time that none of the COVID-19 patients had positive SARS-CoV-2 RNA in EPS. To this end, this study found the negativity of SARS-CoV-2 in EPS and possibly exclude the sexual transmission of COVID-19. |
| اللغة: | English |
| تدمد: | 1873-1708 0890-6238 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3540d80c412840890eb9b18c0fb5384fTest http://europepmc.org/articles/PMC7286226Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3540d80c412840890eb9b18c0fb5384f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18731708 08906238 |
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