Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol for a multicentre, randomised, controlled trial

التفاصيل البيبلوغرافية
العنوان: Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol for a multicentre, randomised, controlled trial
المؤلفون: Xiang Lei, Yue Jing, Tianhong Cui, Zengtao Sun, Jin Jin, Hongchun Zhang, Yan Zhang, Demin Li, Jihong Feng, Hong Zhang, Erran Li, Jing Zhang, Qijian Cheng
المصدر: BMJ Open
بيانات النشر: BMJ Publishing Group, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Acute exacerbation of chronic obstructive pulmonary disease, Comparative effectiveness research, Decoction, Traditional Chinese medicine, acute exacerbation of chronic obstructive pulmonary disease, law.invention, 03 medical and health sciences, traditional Chinese medicine, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Quality of life, Randomized controlled trial, Double-Blind Method, law, medicine, Protocol, Humans, 030212 general & internal medicine, Medicine, Chinese Traditional, Intensive care medicine, Adverse effect, Aged, Protocol (science), Aged, 80 and over, business.industry, General Medicine, Middle Aged, medicine.disease, Treatment Outcome, comparative effectiveness research, Acute Disease, Complementary Medicine, Female, business, 030217 neurology & neurosurgery, Drugs, Chinese Herbal
الوصف: IntroductionAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) brings a serious impact on patients’ quality of life, and has extremely high morbidity and mortality worldwide. Although there are many therapies being developed to alleviate symptoms and reduce mortality, a few studies have supported which treatment method is the best. Traditional Chinese medicine (TCM) has shown good potential in the prevention and treatment of AECOPD, especially in terms of supplementation and reduction of dosage and adverse effect of Western medicine. The purpose of this study is to compare the effectiveness of combination of TCM and Western medicine with conventional therapy alone for AECOPD, and to ensure whether the combined therapy may reduce the use of systemic glucocorticoid in AECOPD without influencing efficacy.Methods and analysisA multicentre, randomised, double-blind, placebo-controlled study was conducted to enrol a total of 360 eligible patients who will be randomised into integrated Chinese and Western medicine group A, B and Western standard Medicine group C. After 5 days of intervention and 1 month of follow-up, the efficacy and safety of Xin Jia Xuan Bai Cheng Qi Decoction in patients with AECOPD will be observed. The results of evaluation indicators include: clinical symptoms, biochemical indicators such as blood gas analysis, inflammatory markers, hospitalisation time, TCM syndrome evaluation, biological indicators such as airway, intestinal flora sequencing.Ethics and disseminationThis trail has been approved by the Ethics Committee of China-Japan Friendship Hospital. The results will be disseminated in international peer-reviewed journals and be presented in academic conferences. The results will also be disseminated to patients by telephone, inquiring on patient’s poststudy health status during the follow-up.Trial registration numberChiCTR1800016915
اللغة: English
تدمد: 2044-6055
1800-0169
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e339dd6a7dbdb4ca38208d41976e5bTest
http://europepmc.org/articles/PMC6924718Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....70e339dd6a7dbdb4ca38208d41976e5b
قاعدة البيانات: OpenAIRE