Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes
| العنوان: | Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes |
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| المؤلفون: | Elizabeth R. Seaquist, Amir Moheet, Dinesh K. Deelchand, Amir Khowaja, Nathan Rubin, Gülin Öz, Anjali Kumar, Petr Bednařík, Lynn E. Eberly, Pierre Gilles Henry |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Endocrinology, Diabetes and Metabolism, Recurrent hypoglycemia, Clinical Biochemistry, Context (language use), Hypoglycemia, Hippocampal formation, Hippocampus, Biochemistry, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Neurochemical, Diabetes mellitus, Internal medicine, medicine, Humans, business.industry, Biochemistry (medical), Glucose transporter, Middle Aged, Glucose clamp technique, medicine.disease, Up-Regulation, Kinetics, Diabetes Mellitus, Type 1, Glucose, Hyperglycemia, Glucose Clamp Technique, Female, Corrigendum, business, 030217 neurology & neurosurgery |
| الوصف: | Context Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical profile and glucose transport is unknown. Objective To test the hypothesis that hippocampal neurochemical composition is altered in T1D and glucose transport is upregulated in T1D with IAH. Design and participants Hippocampal neurochemical profile was measured with single-voxel magnetic resonance spectroscopy at 3T during euglycemia in 18 healthy controls (HC), 10 T1D with IAH, and 12 T1D with normal awareness to hypoglycemia (NAH). Additionally, 12 HC, 8 T1D-IAH, and 6 T1D-NAH were scanned during hyperglycemia to assess hippocampal glucose transport with metabolic modeling. Setting University medical center. Main Outcome Measures Concentrations of hippocampal neurochemicals measured during euglycemia and ratios of maximal transport rate to cerebral metabolic rate of glucose (Tmax/CMRGlc), derived from magnetic resonance spectroscopy–measured hippocampal glucose as a function of plasma glucose. Results Comparison of hippocampal neurochemical profile revealed no group differences (HC, T1D, T1D-IAH, and T1D-NAH). The ratio Tmax/CMRGlc was not significantly different between the groups, T1D-IAH (1.58 ± 0.09) and HC (1.65 ± 0.07, P = 0.54), between T1D-NAH (1.50 ± 0.09) and HC (P = 0.19), and between T1D-IAH and T1D-NAH (P = 0.53). Conclusions Subjects with T1D with sufficient exposure to recurrent hypoglycemia to create IAH did not have alteration of Tmax/CMRglc or neurochemical profile compared with participants with T1D-NAH or HC. |
| اللغة: | English |
| تدمد: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgz062 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1279256c3298ab63180aa83f271f8b8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a1279256c3298ab63180aa83f271f8b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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| DOI: | 10.1210/clinem/dgz062 |