Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases
| العنوان: | Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases |
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| المؤلفون: | Ramsha Khalid, Sundus Khalid, Muhammad Usman, Abdullah F. Alasmari, Muhammad Fawad Rasool, Shazia Ali, Mohsin Ali, Ali Mohammed Asiri, Abdul Majeed, Fawaz Alasmari, Imran Imran, Faleh Alqahtani, Hamid Saeed, Nemat Ali, Amer S. Alali |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Physiologically based pharmacokinetic modelling, Captopril, Adolescent, Science, Population, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Disease severity, medicine, Humans, Drug-disease, Renal Insufficiency, Chronic, education, Aged, Aged, 80 and over, Heart Failure, education.field_of_study, Multidisciplinary, business.industry, Reproducibility of Results, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Heart failure, Chronic Disease, Injections, Intravenous, Medicine, Female, Clinical pharmacology, business, medicine.drug, Kidney disease |
| الوصف: | The advancement in the processing speeds of computing machines has facilitated the development of complex physiologically based pharmacokinetic (PBPK) models. These PBPK models can incorporate disease-specific data and could be used to predict pharmacokinetics (PK) of administered drugs in different chronic conditions. The present study aimed to develop and evaluate PBPK drug-disease models for captopril after incorporating relevant pathophysiological changes occurring in adult chronic kidney disease (CKD) and chronic heart failure (CHF) populations. The population-based PBPK simulator Simcyp was used as a modeling and simulation platform. The visual predictive checks and mean observed/predicted ratios (ratio(Obs/pred)) of the PK parameters were used for model evaluation. The developed disease models were successful in predicting captopril PK in all three stages of CKD (mild, moderate, and severe) and CHF, as the observed and predicted PK profiles and the ratio(obs/pred) for the PK parameters were in close agreement. The developed captopril PBPK models can assist in tailoring captopril dosages in patients with different disease severity (CKD and CHF). |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e194a4ba856a1b86c28d8fa111e096Test https://doi.org/10.1038/s41598-021-88154-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....19e194a4ba856a1b86c28d8fa111e096 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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