Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes
| العنوان: | Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes |
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| المؤلفون: | Genevieve Boulet, Narinder Paul, Leif E. Lovblom, Julie A. Lovshin, Hillary A. Keenan, Josephine Tse, Bruce A. Perkins, Vesta Lai, Nigar Sekercioglu, Leslie Cham, Vera Bril, David Z.I. Cherney, Yuliya Lytvyn, Mohammed A. Farooqi, Andrej Orszag, Michael H. Brent, Petter Bjornstad |
| المصدر: | Renal Failure Renal Failure, Vol 41, Iss 1, Pp 427-433 (2019) |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Canada, medicine.medical_specialty, Diabetic neuropathy, media_common.quotation_subject, Longevity, 030232 urology & nephrology, Disease, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Independent predictor, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Risk Factors, Diabetes mellitus, Internal medicine, Prevalence, medicine, Humans, Diabetic Nephropathies, Aged, media_common, Type 1 diabetes, Diabetic kidney, urogenital system, business.industry, Age Factors, General Medicine, Diabetic retinopathy, Middle Aged, medicine.disease, Diseases of the genitourinary system. Urology, diabetic kidney disease, diabetic neuropathy, diabetic retinopathy, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Nephrology, Clinical Study, Female, RC870-923, business |
| الوصف: | Objectives: Diabetic kidney disease (DKD) is an independent predictor of cardiovascular morbidity and mortality in type 1 diabetes (T1D). We aimed to explore clinical and biochemical factors, including the achievement of American Diabetes Association (ADA) recommended targets associated with DKD in people living with T1D for ≥50 years. Methods: This was a post hoc analysis of a cross-sectional study of 75 participants enrolled in the Canadian Study of Longevity in T1D. We explored diabetes-related complications, including neuropathy, retinopathy, cardiovascular disease, and DKD. Study participants were dichotomized based on the achievement of ADA recommended targets as the low-target group (achieving ≤4 targets, n = 31) and high-target group (achieving >4 targets, n = 44). The outcome of interest was DKD defined by estimated glomerular filtration rate (eGFR) values 30 mg. Multivariable logistic regression models were employed to estimate odds ratios (ORs) for DKD with 95% confidence intervals (CIs). Results: Of the 75 participants with prolonged T1D duration (45% male, mean age 66 years), 25 participants had DKD and 50 did not. There was no statistical difference between the high- and low-target groups in terms of age and body mass index. eGFR was significantly higher and the prevalence of diabetic retinopathy was significantly lower in the high-target group. Older age at diagnosis of T1D and lower frequency component to high-frequency component ratio increased the odds of having DKD. Conclusions: In adults with prolonged T1D duration, older age at diagnosis and lower heart rate variability may be associated with DKD. |
| تدمد: | 1525-6049 0886-022X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf35525fda0be7c1a1c1db15ad3d785Test https://doi.org/10.1080/0886022x.2019.1614057Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....edf35525fda0be7c1a1c1db15ad3d785 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15256049 0886022X |
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