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المؤلفون: Fangming Liu, Xiaochen Gai, Yuting Wu, Baohui Zhang, Xiaoyu Wu, Rongrong Cheng, Bufu Tang, Kezhuo Shang, Na Zhao, Weiwei Deng, Jie Chen, Zhengyi Zhang, Song Gu, Liang Zheng, Hongbing Zhang
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 39
مصطلحات موضوعية: Liver Cancer, Carcinogenesis, Chronic Liver Disease and Cirrhosis, Phosphates, Ligases, Mice, Rare Diseases, Drug Delivery Systems, pyrimidine synthesis, Genetics, 2.1 Biological and endogenous factors, Animals, CAD, Aetiology, Dihydroorotase, beta Catenin, Cancer, AKT2, Aspartic Acid, Multidisciplinary, Nucleotides, Liver Disease, Liver Neoplasms, beta-catenin, β-catenin, Good Health and Well Being, Pyrimidines, Digestive Diseases, Proto-Oncogene Proteins c-akt
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e982c455d244c18c469f705b80e00a55Test
https://pubmed.ncbi.nlm.nih.gov/36122209Test -
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المؤلفون: Simon Hansen, Yingnan Zhang, Sunhee Hwang, Ahmad Nabhan, Wanqing Li, Jakob Fuhrmann, Yvonne Kschonsak, Lijuan Zhou, Aaron H. Nile, Xinxin Gao, Robert Piskol, Felipe de Sousa e Melo, Frederic J. de Sauvage, Rami N. Hannoush
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(46)
مصطلحات موضوعية: Wnt Proteins, Multidisciplinary, Low Density Lipoprotein Receptor-Related Protein-6, Humans, Cystine, Ligands, Peptides, Wnt Signaling Pathway, beta Catenin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946fbdbd9489e01d82fe26bb74316f96Test
https://pubmed.ncbi.nlm.nih.gov/36343233Test -
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المؤلفون: Anja, Tursch, Natascha, Bartsch, Moritz, Mercker, Jana, Schlüter, Mark, Lommel, Anna, Marciniak-Czochra, Suat, Özbek, Thomas W, Holstein
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(35)
مصطلحات موضوعية: Hydra, JNK Mitogen-Activated Protein Kinases, Animals, Extracellular Signal-Regulated MAP Kinases, Wnt Signaling Pathway, p38 Mitogen-Activated Protein Kinases, beta Catenin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::546dbbd22609a13d0a2adb35e2254f1fTest
https://pubmed.ncbi.nlm.nih.gov/35994642Test -
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المؤلفون: Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(30)
مصطلحات موضوعية: Repressor Proteins, Mice, Multidisciplinary, Hepatocytes, Animals, Mitosis, T-Box Domain Proteins, Wnt Signaling Pathway, beta Catenin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccc9ef7d1c55d6d6bfee01618702185Test
https://pubmed.ncbi.nlm.nih.gov/35867815Test -
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المؤلفون: Antonia Schubert, Oksana Voloshanenko, Franziska Ragaller, Philipp Gmach, Dominique Kranz, Christian Scheeder, Thilo Miersch, Matthias Schulz, Lorenz Trümper, Claudia Binder, Marko Lampe, Ulrike Engel, Michael Boutros
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(30)
مصطلحات موضوعية: Biomolecular Condensates, Wnt Proteins, Multidisciplinary, Microscopy, Fluorescence, Protein Domains, Dishevelled Proteins, Humans, Wnt Signaling Pathway, beta Catenin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753bfecdc16cd5d698c77749d3369317Test
https://pubmed.ncbi.nlm.nih.gov/35867833Test -
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المؤلفون: Sören Franzenburg, Doris Willoweit-Ohl, Sebastian Fraune, Jan Taubenheim, Mirjam Knop, Thomas C. G. Bosch, Jinru He
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: Hydra, host–microbe interaction, phenotypic plasticity, Gene expression, Animals, Wnt Signaling Pathway, beta Catenin, Body Patterning, Abiotic component, Phenotypic plasticity, Multidisciplinary, biology, Bacteria, Wnt signaling pathway, orphan gene, Temperature, Gene Expression Regulation, Developmental, Biological Sciences, Orphan gene, biology.organism_classification, Wnt signaling, Cell biology, Wnt Proteins, Eco-Evo-Devo, Lernaean Hydra, Gene-Environment Interaction, Peptides, Function (biology), Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c1dee373f0ae08082b8388c0f9f4a3Test
http://europepmc.org/articles/PMC7474684Test -
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المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S Aمصطلحات موضوعية: Medical Sciences, Epithelial-Mesenchymal Transition, Carcinogenesis, Correction, Gene Expression, Breast Neoplasms, Biological Sciences, Aldehyde Dehydrogenase, Hypoxia-Inducible Factor 1, alpha Subunit, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Cell Line, Tumor, Disease Progression, Neoplastic Stem Cells, Humans, Female, Breast, Hypoxia-Inducible Factor 1, Calreticulin, Wnt Signaling Pathway, beta Catenin, Cell Proliferation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16972f7c355b07e576f92805f638be2dTest
http://europepmc.org/articles/PMC8794775Test -
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المؤلفون: Gabriel Rosenblum, Wenwei Zheng, Artem Dubovetskyi, Samuel Wohl, Hagen Hofmann, Felix Wiggers
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: Protein Folding, Protein Conformation, Biophysics, IDP, Molecular Dynamics Simulation, Intrinsically disordered proteins, Ligands, single-molecule FRET, Dissociation (psychology), molecular simulation, Diffusion, Antigens, CD, medicine, Humans, Diffusion (business), beta Catenin, Multidisciplinary, Chemistry, Ligand, Protein dynamics, Energy landscape, Single-molecule FRET, Biological Sciences, Cadherins, Receptor–ligand kinetics, Intrinsically Disordered Proteins, Biophysics and Computational Biology, Kinetics, Chemical physics, protein dynamics, fuzzy complex, medicine.symptom
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f78b3669cdd8580edfdcdde84711974Test
http://europepmc.org/articles/PMC8449409Test -
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المؤلفون: Silvia Corrochano, Abigail Harris, Hans Clevers, Caroline Eozenou, Isabelle Stévant, Joelle Bignon-Topalovic, Nick Warr, Neila Belguith, Sara Wells, Bochra Ben Rhouma, Pam Siggers, Serge Nef, Daniel T. Grimes, Ken McElreavey, Rebecca D. Burdine, Feng Cong, Makoto Suzuki, Andy Greenfield, Danielle Sagar, Anu Bashamboo, Bon-Kyoung Koo, Raja Brauner
المساهمون: Medical Research Coucil Harwell [Oxford, UK] (MRC Harwell), MRC Harwell, Department of Molecular Biology [Princeton], Princeton University, Novartis Institutes for BioMedical Research (NIBR), Hubrecht Institute [Utrecht, Netherlands], University Medical Center [Utrecht]-Royal Netherlands Academy of Arts and Sciences (KNAW), Université de Genève = University of Geneva (UNIGE), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Université Paris Descartes - Paris 5 (UPD5), Faculté de médecine - Faculty of Medicine [Sfax, Tunisie] (FMS), Université de Sfax - University of Sfax, Génétique du Développement humain - Human developmental genetics, Institut Pasteur [Paris] (IP), This work was supported by the Medical Research Council by core funding Grant MC_U142684167 (to A.G.) at the Harwell Institute, and the Agence Nationale de la Recherche Grant ANR-10-LABX-73 (to K.M.). S.N. acknowledges support from Swiss National Science Foundation Grant 31003A_173070. M.S. was a visiting scientist supported by the Strategic International Research Exchange Program between Princeton University and National Institutes of Natural Sciences, Japan. D.T.G. was supported by National Institute of Arthritis and Mucoskeletal and Skin Diseases Pathway to Independence Award 1K99AR070905. Work in the R.D.B. laboratory is supported by the National Institute of Child Health and Development Grant 2R01HD048584., We thank the husbandry team in Ward 5 of the Mary Lyon Centre at Harwell and the Frozen Embryo and Sperm Archive (FESA) and histology teams. We thank Dagmar Wilhelm for the kind gift of anti-FOXL2 antibody. We thank Phil Johnson for zebrafish husbandry. We acknowledge European Cooperation in Science & Technology (COST) Action BM1303 (DSDnet)., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), Université de Genève (UNIGE), Génétique du développement humain, Institut Pasteur [Paris], Hubrecht Institute for Developmental Biology and Stem Cell Research
المصدر: Proceedings of the National Academy of Sciences, Vol. 115, No 21 (2018) pp. 5474-5479
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciencesمصطلحات موضوعية: 0301 basic medicine, Male, Embryo, Nonmammalian, Sex Differentiation, Organogenesis, Wnt Proteins/antagonists & inhibitors, Disorders of Sex Development, DSD, MESH: Wnt Proteins / metabolism, MESH: Testis / metabolism, MESH: Disorders of Sex Development / genetics, MESH: Testis / pathology, MESH: Embryo, Nonmammalian / cytology, Mice, Embryo, Nonmammalian/cytology, MESH: Gene Expression Regulation, Developmental, Testis, Missense mutation, MESH: Animals, ddc:576.5, Developmental, Disorders of sex development, 10. No inequality, MESH: Ubiquitin-Protein Ligases / genetics, Exome sequencing, Cells, Cultured, beta Catenin, Zebrafish, Multidisciplinary, Cultured, MESH: Thrombospondins / genetics, MESH: SOX9 Transcription Factor / metabolism, Wnt signaling pathway, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, beta Catenin/antagonists & inhibitors, MESH: beta Catenin / metabolism, Sex reversal, MESH: Gonads / pathology, Cell biology, MESH: Young Adult, Embryo, MESH: Gonads / metabolism, Female, MESH: Cells, Cultured, Adult, Adolescent, Ubiquitin-Protein Ligases, Cells, Thrombospondins/genetics, Mutation, Missense, MESH: beta Catenin / antagonists & inhibitors, SOX9, Biology, Gonads/metabolism, MESH: Embryo, Nonmammalian / metabolism, 03 medical and health sciences, Young Adult, MESH: Wnt Proteins / genetics, WNT signaling, medicine, Animals, Humans, Ubiquitin-Protein Ligases/genetics, MESH: SOX9 Transcription Factor / genetics, MESH: Zebrafish, RSPO1, Gonads, General, MESH: Mice, Nonmammalian/cytology, MESH: Disorders of Sex Development / pathology, MESH: Adolescent, MESH: Wnt Proteins / antagonists & inhibitors, MESH: Mutation, Missense, MESH: Humans, MESH: beta Catenin / genetics, ZNRF3, MESH: Adult, Sex determination, medicine.disease, MESH: Male, MESH: Ubiquitin-Protein Ligases / physiology, SOX9 Transcription Factor/genetics, Wnt Proteins, 030104 developmental biology, MESH: Thrombospondins / metabolism, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Gene Expression Regulation, Mutation, Testis/metabolism, Missense, Thrombospondins, MESH: Female, Function (biology), Disorders of Sex Development/genetics, MESH: Sex Differentiation
وصف الملف: image/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785b7c346bbb98027161ca7382405e7Test
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58Test -
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المؤلفون: Caroline, Eozenou, Nitzan, Gonen, Maria Sol, Touzon, Anne, Jorgensen, Svetlana A, Yatsenko, Leila, Fusee, Alaa K, Kamel, Balazs, Gellen, Gabriela, Guercio, Priti, Singh, Selma, Witchel, Andrea J, Berman, Rana, Mainpal, Mehdi, Totonchi, Anahita, Mohseni Meybodi, Masomeh, Askari, Tiphanie, Merel-Chali, Joelle, Bignon-Topalovic, Roberta, Migale, Mariana, Costanzo, Roxana, Marino, Pablo, Ramirez, Natalia, Perez Garrido, Esperanza, Berensztein, Mona K, Mekkawy, John C, Schimenti, Rita, Bertalan, Inas, Mazen, Ken, McElreavey, Alicia, Belgorosky, Robin, Lovell-Badge, Aleksandar, Rajkovic, Anu, Bashamboo
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: Male, Medical Sciences, 46, XX Testicular Disorders of Sex Development, organogenesis, Ovary, sex determination, Infant, Zinc Fingers, Biological Sciences, WT1, Mice, 46,XX TDSD/OTDSD, Child, Preschool, Testis, β-CATENIN, Animals, Humans, Female, WT1 Proteins, beta Catenin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::494cb668f23b408c21730411a68e42f5Test
https://pubmed.ncbi.nlm.nih.gov/32493750Test