Bacterial Meningitis in Children: Neurological Complications, Associated Risk Factors, and Prevention
| العنوان: | Bacterial Meningitis in Children: Neurological Complications, Associated Risk Factors, and Prevention |
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| المؤلفون: | Abdulwahed Zainel, Manish Sadarangani, Hana Mitchell |
| المصدر: | Microorganisms Microorganisms, Vol 9, Iss 535, p 535 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), Pediatrics, medicine.medical_specialty, corticosteroid, Hearing loss, seizure, dexamethasone, Review, medicine.disease_cause, Microbiology, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, 030225 pediatrics, Virology, vaccine, Streptococcus pneumoniae, Case fatality rate, medicine, 030212 general & internal medicine, neurological sequelae, Subdural effusion, lcsh:QH301-705.5, hearing loss, focal neurological deficit, business.industry, Neisseria meningitidis, medicine.disease, Hydrocephalus, Vaccination, lcsh:Biology (General), epilepsy, medicine.symptom, business, bacterial meningitis, hydrocephalus |
| الوصف: | Bacterial meningitis is a devastating infection, with a case fatality rate of up to 30% and 50% of survivors developing neurological complications. These include short-term complications such as focal neurological deficit and subdural effusion, and long-term complications such as hearing loss, seizures, cognitive impairment and hydrocephalus. Complications develop due to bacterial toxin release and the host immune response, which lead to neuronal damage. Factors associated with increased risk of developing neurological complications include young age, delayed presentation and Streptococcus pneumoniae as an etiologic agent. Vaccination is the primary method of preventing bacterial meningitis and therefore its complications. There are three vaccine preventable causes: Haemophilus influenzae type b (Hib), S. pneumoniae, and Neisseria meningitidis. Starting antibiotics without delay is also critical to reduce the risk of neurological complications. Additionally, early adjuvant corticosteroid use in Hib meningitis reduces the risk of hearing loss and severe neurological complications. |
| اللغة: | English |
| تدمد: | 2076-2607 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f78dc9bedec77c696bb7dfa9d7a898Test http://europepmc.org/articles/PMC8001510Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4f78dc9bedec77c696bb7dfa9d7a898 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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