Lycium barbarum relieves gut microbiota dysbiosis and improves colonic barrier function in mice following antibiotic perturbation
| العنوان: | Lycium barbarum relieves gut microbiota dysbiosis and improves colonic barrier function in mice following antibiotic perturbation |
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| المؤلفون: | Juxiu Li, Lizhi Yu, Wei An, Yilin Liu, Baoming Tian, Jianhua Zhao, Mengyao Liu, Jiawei Zhang |
| المصدر: | Journal of Functional Foods, Vol 71, Iss, Pp 103973-(2020) |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Firmicutes, Tight junction proteins, Medicine (miscellaneous), Gut microbiota, Gut flora, Microbiology, 03 medical and health sciences, 0404 agricultural biotechnology, Enterococcaceae, medicine, TX341-641, Barrier function, 030109 nutrition & dietetics, Nutrition and Dietetics, biology, Nutrition. Foods and food supply, Chemistry, Lachnospiraceae, Antibiotic, Akkermansia, 04 agricultural and veterinary sciences, Colonic barrier function, biology.organism_classification, medicine.disease, 040401 food science, Enterobacteriaceae, Lycium barbarum, Dysbiosis, Food Science |
| الوصف: | Diet and antibiotic strongly affect human health by modulating gut microbiota (GM) composition. To investigate how Lycium barbarum (LB) relieves GM dysbiosis and enhances colonic barrier function, C57BL/6 mice were chronically exposed to sub-therapeutic antibiotic dosages or not (control), and fed a 1.5% LB diet for 10 weeks. HiSeq sequencing of 16S rDNA revealed that oral antibiotics distinctly lowered the microbial diversity and richness, Bacteroidetes, Firmicutes, Bacteroidales_S24-7_group, Lachnospiraceae, Ruminococcaceae, Lachnospiraceae_NK4A136_group, Lachnoclostridium, Akkermansia, Anaerotruncus, and Odoribacter, as well as increased Proteobacteria, Enterobacteriaceae, Enterococcaceae, Escherichia-Shigella, Morganella, and Enterococcus. Compared with the antibiotic-treated group, dietary LB reversed the variations in these bacteria, improved the abundance of certain short-chain fatty acid (SCFA)-producing bacteria, SCFA concentrations, and decreased fecal ammonia and pH value. Accordingly, this promoted the expression of tight junction proteins, immune barrier, sequentially improved barrier function, histomorphology, and development in the intestine. The results show that dietary LB can partially mitigate antibiotics-induced dysbiosis. |
| تدمد: | 1756-4646 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20f7eb0d1705c65f72bd0c6f8dca3abTest https://doi.org/10.1016/j.jff.2020.103973Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b20f7eb0d1705c65f72bd0c6f8dca3ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17564646 |
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