Epidemiological analysis of the association between hearing and barium in humans
| العنوان: | Epidemiological analysis of the association between hearing and barium in humans |
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| المؤلفون: | Ohgami, Nobutaka, Mitsumatsu, Yuji, Ahsan, Nazmul, Anwarul, Azim Akhand, Li, Xiang, Iida, Machiko, Yajima, Ichiro, Naito, Mariko, Wakai, Kenji, Ohnuma, Shoko, Kato, Masashi |
| المصدر: | Journal of Exposure Science and Environmental Epidemiology. 26:488-493 |
| بيانات النشر: | nature, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | otorhinolaryngologic diseases |
| الوصف: | Our previous study experimentally showed barium (Ba)-mediated hearing loss in mice. To our knowledge, however, it remains unknown whether Ba affects hearing in humans. This epidemiological study aimed at investigating ototoxicity of Ba in humans. Associations of Ba levels in hair, toenails and urine with hearing levels (1, 4, 8 and 12 kHz) were analyzed in 145 Bangladeshi subjects. Binary logistic regression analysis with adjustment for age, sex, body mass index (BMI) and smoking showed that Ba levels in hair had significant associations with hearing loss at 8 kHz (OR=4.75; 95% CI: 1.44, 17.68) and 12 kHz (OR=15.48; 95% CI: 4.04, 79.45). Ba levels in toenails were also associated with hearing loss at 8 kHz (OR=3.20; 95% CI: 1.35, 7.85) and 12 kHz (OR=3.63; 95% CI: 1.58, 8.55), whereas there was no correlation between Ba level in urinary samples and hearing. There was a significant correlation between hearing loss and Ba levels in hair and toenails in the model adjusted with arsenic levels as the confounder. In conclusion, this study suggested that Ba levels could be a new risk factor for hearing loss, especially at high frequencies of 8 and 12 kHz, in humans. advance online publication, October 14, 2015 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1559-0631 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=jairo_______::80cd8da9a8875a4825906e8b03e332d0Test https://nagoya.repo.nii.ac.jp/records/22808Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.jairo.........80cd8da9a8875a4825906e8b03e332d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590631 |
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