نتائج البحث

1

Characterization of Cholesterol Homeostasis in Telomerase-immortalized Tangier Disease Fibroblasts Reveals Marked Phenotype Variability

المؤلفون: Michael G. Roth, Michael Walter, Stephan Rust, Kerstin Gorzelniak, Kathrin Jäger, Joyce J. Repa, Frank Kannenberg, Ingemar Björkhem, Manfred Fobker

المصدر: Journal of Biological Chemistry. 288:36936-36947

مصطلحات موضوعية: Adult, Premature aging, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Telomerase, Apolipoprotein B, Mutation, Missense, Biochemistry, chemistry.chemical_compound, Tangier disease, Internal medicine, medicine, Humans, Molecular Biology, Cellular Senescence, Tangier Disease, Cell Line, Transformed, Apolipoprotein A-I, biology, Cholesterol, nutritional and metabolic diseases, Cell Biology, Fibroblasts, Atherosclerosis, medicine.disease, Lipids, Endocrinology, ATP Binding Cassette Transporter 1, Amino Acid Substitution, chemistry, Gene Knockdown Techniques, ABCA1, biology.protein, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, Cell aging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f359692e9acf79dc5df625669c8177Test
https://doi.org/10.1074/jbc.m113.500256Test

2

The E1015K Variant in the Synprint Region of the CaV2.1 Channel Alters Channel Function and Is Associated with Different Migraine Phenotypes

المؤلفون: Patrizia Rosa, A. Fratangeli, Steven B. Condliffe, Nehan R. Munasinghe, Cristina Montrasio, Paola Carrera, Maria Passafaro, Maurizio Ferrari, Elena Saba

المساهمون: Sb, Condliffe, A., Fratangeli, N. R., Munasinghe, E., Saba, M., Passafaro, C., Montrasio, Ferrari, Maurizio, P., Rosa, P., Carrera

المصدر: Journal of Biological Chemistry. 288:33873-33883

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Synaptosomal-Associated Protein 25, Protein subunit, Migraine with Aura, Mutation, Missense, Presynaptic Terminals, Syntaxin 1, Nerve Tissue Proteins, Hippocampus, Biochemistry, Cav2.1, Calcium Channels, N-Type, Neurobiology, Internal medicine, medicine, Animals, Humans, Child, Molecular Biology, Familial hemiplegic migraine, Ion Transport, Voltage-dependent calcium channel, biology, Calcium channel, fungi, HEK 293 cells, Wild type, food and beverages, Cell Biology, Middle Aged, medicine.disease, Migraine with aura, Rats, Cell biology, HEK293 Cells, Endocrinology, Amino Acid Substitution, cardiovascular system, biology.protein, Female, Rabbits, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7980f66a1b455f9f59d8412baa6b9820Test
https://doi.org/10.1074/jbc.m113.497701Test

3

The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients

المؤلفون: George C. Tsokos, Kamalpreet Nagpal, Katsue Sunahori, Masayuki Mizui, Lisa M. Fitzgerald, Christian M. Hedrich

المصدر: Journal of Biological Chemistry. 288:21936-21944

مصطلحات موضوعية: Adult, DNA (Cytosine-5-)-Methyltransferase 1, MAPK/ERK pathway, T-Lymphocytes, Immunology, Immunoblotting, Gene Expression, macromolecular substances, Biology, environment and public health, Biochemistry, DNA methyltransferase, Young Adult, immune system diseases, Humans, Lupus Erythematosus, Systemic, DNA (Cytosine-5-)-Methyltransferases, Protein Phosphatase 2, Phosphorylation, skin and connective tissue diseases, Extracellular Signal-Regulated MAP Kinases, Molecular Biology, Cells, Cultured, Reverse Transcriptase Polymerase Chain Reaction, Ionomycin, Cell Biology, Protein phosphatase 2, DNA Methylation, Middle Aged, Molecular biology, enzymes and coenzymes (carbohydrates), Mitogen-activated protein kinase, DNA methylation, DNMT1, biology.protein, Tetradecanoylphorbol Acetate, Female, RNA Interference, Mitogen-Activated Protein Kinases, Signal transduction, CD27 Ligand, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3da8f0367725f3580b37e4d83c6ab7eTest
https://doi.org/10.1074/jbc.m113.467266Test

4

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

المؤلفون: Zhiyong Zhang, Beatrice Haimovich, Stephen F. Lowry, Leonard Guarente

المصدر: Journal of Biological Chemistry. 285:41391-41401

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Porphyrins, Adolescent, Inflammation, Heme, Resveratrol, Systemic inflammation, Biochemistry, Mice, chemistry.chemical_compound, Sirtuin 1, Internal medicine, medicine, Animals, Humans, Protein kinase A, Molecular Biology, biology, Autophagy, AMPK, Cell Biology, Endocrinology, Tetrapyrroles, chemistry, Metals, Mutation, Immunology, Enzymology, biology.protein, Female, medicine.symptom, Ferrochelatase, Homeostasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e59e7a33f99de761d8688107864ebc0Test
https://doi.org/10.1074/jbc.m110.174482Test

5

Molecular Cloning of a Brain-specific, Developmentally Regulated Neuregulin 1 (NRG1) Isoform and Identification of a Functional Promoter Variant Associated with Schizophrenia

المؤلفون: Daniel R. Weinberger, Wei Tan, Bert Gold, Michael Dean, Amanda J. Law, Yanhong Wang, Paul Harrison, Jingshan Chen

المصدر: Journal of Biological Chemistry. 282:24343-24351

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9261e01ff07e51f81a3c0168c0aaffTest
https://doi.org/10.1074/jbc.m702953200Test

6

Human Serum from Patients with Septic Shock Activates Transcription Factors STAT1, IRF1, and NF-κB and Induces Apoptosis in Human Cardiac Myocytes

المؤلفون: Chilakamarti V. Ramana, Aseem Kumar, Paul Michael, Anand Kumar, Xiulong Xu, Amadeo M. Parissenti, Joseph E. Parrillo, Danielle Brabant

المصدر: Journal of Biological Chemistry. 280:42619-42626

مصطلحات موضوعية: Male, Transcription, Genetic, Apoptosis, Biochemistry, chemistry.chemical_compound, Genes, Reporter, Myocytes, Cardiac, STAT1, biology, Cell adhesion molecule, Caspase 1, NF-kappa B, Middle Aged, Shock, Septic, STAT1 Transcription Factor, Female, Adult, medicine.medical_specialty, Blotting, Western, Immunoblotting, Enzyme-Linked Immunosorbent Assay, Transfection, Proinflammatory cytokine, Fetus, Sepsis, Internal medicine, medicine, Humans, Mitogen-Activated Protein Kinase 9, Mitogen-Activated Protein Kinase 8, Molecular Biology, Transcription factor, Inflammation, Tumor Necrosis Factor-alpha, Septic shock, Myocardium, JNK Mitogen-Activated Protein Kinases, NF-κB, DNA, Trypan Blue, Cell Biology, medicine.disease, Endocrinology, chemistry, biology.protein, Cancer research, Cell Adhesion Molecules, Interferon Regulatory Factor-1, Interleukin-1, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efceaf2c83fd62cd57a615353128c75Test
https://doi.org/10.1074/jbc.m508416200Test

7

Impaired ABCA1-dependent Lipid Efflux and Hypoalphalipoproteinemia in Human Niemann-Pick type C Disease

المؤلفون: Jean E. Vance, Gordon A. Francis, William S. Garver, Wenda L. Greer, Barbara Karten, Hong Y. Choi, Teddy Chan, Randall A. Heidenreich

المصدر: Journal of Biological Chemistry. 278:32569-32577

مصطلحات موضوعية: Male, Time Factors, Biochemistry, Low-density lipoprotein receptor activity, chemistry.chemical_compound, High-density lipoprotein, hemic and lymphatic diseases, Child, Hypoalphalipoproteinemia, Phospholipids, Tangier Disease, Niemann-Pick Diseases, biology, Reverse Transcriptase Polymerase Chain Reaction, Sphingomyelins, Lipoproteins, LDL, Cholesterol, Child, Preschool, Phosphatidylcholines, Female, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, ATP Binding Cassette Transporter 1, Protein Binding, Adult, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Adolescent, Lipoproteins, Blotting, Western, Sex Factors, Internal medicine, medicine, Humans, RNA, Messenger, Molecular Biology, Apolipoprotein A-I, nutritional and metabolic diseases, Lipid metabolism, Cell Biology, Fibroblasts, Blotting, Northern, Lipid Metabolism, medicine.disease, nervous system diseases, Endocrinology, chemistry, ABCA1, Mutation, biology.protein, ATP-Binding Cassette Transporters, NPC1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89a35d7629eb3f6116833ad992c41baTest
https://doi.org/10.1074/jbc.m304553200Test

8

A Novel Superoxide-producing NAD(P)H Oxidase in Kidney

المؤلفون: Hideki Sumimoto, Masahira Hattori, Junya Kuroda, Momoki Hirai, Akira Shiose, Hideki Hirakata, Seiji Naito, Yoshiyuki Sakaki, Kazuhiko Tsuruya

المصدر: Journal of Biological Chemistry. 276:1417-1423

مصطلحات موضوعية: Adult, Phagocyte, Molecular Sequence Data, Biology, Transfection, Biochemistry, Gene Expression Regulation, Enzymologic, Cell Line, chemistry.chemical_compound, Fetus, Bacterial Proteins, Superoxides, medicine, Humans, NADH, NADPH Oxidoreductases, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Molecular Biology, In Situ Hybridization, Fluorescence, Expressed Sequence Tags, Oxidase test, NADPH oxidase, Sequence Homology, Amino Acid, urogenital system, Superoxide, Chromosomes, Human, Pair 11, HEK 293 cells, Chromosome Mapping, Gene Expression Regulation, Developmental, NADPH Oxidases, NOX4, Exons, Cell Biology, Molecular biology, Recombinant Proteins, Kinetics, medicine.anatomical_structure, chemistry, NADPH Oxidase 4, Organ Specificity, NAD(P)H oxidase, Karyotyping, NADPH Oxidase 1, cardiovascular system, biology.protein, NAD+ kinase, Sequence Alignment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30878c28c156164dc21735e47cf84758Test
https://doi.org/10.1074/jbc.m007597200Test

9

A Phosphatidylinositol 3-Kinase/p70 Ribosomal S6 Protein Kinase Pathway Is Required for the Regulation by Insulin of the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase Gene Expression in Human Muscle Cells

المؤلفون: Hubert Vidal, Marina Roques

المصدر: Journal of Biological Chemistry. 274:34005-34010

مصطلحات موضوعية: Adult, medicine.medical_specialty, Transcription, Genetic, Insulin Receptor Substrate Proteins, Morpholines, Recombinant Fusion Proteins, medicine.medical_treatment, P70-S6 Kinase 1, Protein Serine-Threonine Kinases, Regulatory Sequences, Nucleic Acid, Biochemistry, Gene Expression Regulation, Enzymologic, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins, Internal medicine, medicine, Humans, Insulin, RNA, Messenger, Enzyme Inhibitors, Muscle, Skeletal, Protein kinase A, Molecular Biology, Protein kinase B, Cells, Cultured, Flavonoids, Protein Synthesis Inhibitors, Sirolimus, Dose-Response Relationship, Drug, biology, Akt/PKB signaling pathway, Ribosomal Protein S6 Kinases, Cell Biology, Middle Aged, Phosphoproteins, Molecular biology, Receptor, Insulin, IRS2, Insulin receptor, Glycogen Synthase, Endocrinology, Chromones, Dactinomycin, biology.protein, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf0602c9163d108ff65c6c00113fb25Test
https://doi.org/10.1074/jbc.274.48.34005Test

10

Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia

المؤلفون: Miguel C. Seabra, Yiu K. Ho, Janmeet S. Anant

المصدر: Journal of Biological Chemistry. 270:24420-24427

مصطلحات موضوعية: Adult, Male, X Chromosome, Molecular Sequence Data, Protein Prenylation, Biochemistry, rab27 GTP-Binding Proteins, Choroideremia, Rab geranylgeranyltransferase, Cell Line, RAB ESCORT PROTEIN 1, Geranylgeranylation, Prenylation, GTP-Binding Proteins, Transferases, Escherichia coli, medicine, Animals, Humans, Lymphocytes, Cloning, Molecular, RAB27, Molecular Biology, Adaptor Proteins, Signal Transducing, DNA Primers, Alkyl and Aryl Transferases, Base Sequence, biology, Cell Biology, Chromatography, Ion Exchange, medicine.disease, Recombinant Proteins, eye diseases, Rats, Cell biology, Vesicular transport protein, Kinetics, rab GTP-Binding Proteins, Chromatography, Gel, biology.protein, Female, sense organs, Rab, Carrier Proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3761c5f9b5b4fb188145d28bc08c0adTest
https://doi.org/10.1074/jbc.270.41.24420Test

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