Efficacy and safety of rituximab in myasthenia gravis: a French multicentre real‐life study
| العنوان: | Efficacy and safety of rituximab in myasthenia gravis: a French multicentre real‐life study |
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| المؤلفون: | Julien Cassereau, C. Baron, D. Videt, Jean-Baptiste Noury, Armelle Magot, L. Michel, Yann Péréon, Steeve Genestet, A. Nadaj‐Pakleza, A. Dos Santos, Sandrine Wiertlewski |
| المصدر: | European Journal of Neurology. 27:2277-2285 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Bradycardia, medicine.medical_specialty, Cytopenia, business.industry, medicine.disease, Gastroenterology, Myasthenia gravis, 03 medical and health sciences, 0302 clinical medicine, Neurology, Refractory, Internal medicine, medicine, Rituximab, 030212 general & internal medicine, Neurology (clinical), Repetitive nerve stimulation, medicine.symptom, Life study, Adverse effect, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | BACKGROUND AND PURPOSE Fifteen percent of patients with myasthenia gravis (MG) are refractory to conventional treatment. Case reports and a few studies show probable benefit of rituximab in these cases. Our objective was to assess the efficacy and the safety of rituximab in patients with MG, in a multicentric real-life study. METHOD Inclusion criteria were: age > 18 years; MG with anti-acetylcholine receptor (AChR) antibodies, anti-muscle-specific kinase (MuSk) antibodies or significant decrement after repetitive nerve stimulation; Myasthenia Gravis Foundation of America (MGFA) class >II; refractory or steroid-dependent MG; and treatment with rituximab. Efficacy was assessed at 6 months using the MGFA-post-intervention status (PIS) score, the myasthenic muscle score (MMS) and the number of patients receiving steroids |
| تدمد: | 1468-1331 1351-5101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0420f1df22f450fd67edcaf116d0caaeTest https://doi.org/10.1111/ene.14391Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........0420f1df22f450fd67edcaf116d0caae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14681331 13515101 |
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