نتائج البحث

1

Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity

المؤلفون: Eleni Georgiadou, Timothy J. Pullen, Aida Martinez-Sanchez, Guy A. Rutter

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Cell Communication, Review, Disallowed genes, Type 2 diabetes, Epigenetic Repression, Mitochondrion, 03 medical and health sciences, 0302 clinical medicine, Insulin-Secreting Cells, Diabetes mellitus, Glucokinase, Internal Medicine, medicine, Humans, Glucose Transporter Type 2, Type 1 diabetes, biology, Insulin secretion, Beta cells, Glucose transporter, Lipid Metabolism, medicine.disease, Mitochondria, Cell biology, Zinc, Diabetes Mellitus, Type 1, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, Gene Expression Regulation, biology.protein, GLUT2, Beta cell, Oxidation-Reduction, 030217 neurology & neurosurgery, Interconnectivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2941a5e5519021af5f107744d094e767Test
https://doi.org/10.1007/s00125-020-05205-5Test

2

Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice

المؤلفون: Lucy Buckingham, Joanne Davies, Joanne Boldison, Larissa Camargo da Rosa, Li Wen, F. Susan Wong

المصدر: Diabetologia
Boldison, J, Da Rosa, L C, Buckingham, L, Davies, J, Wen, L & Wong, F S 2019, ' Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice ', Diabetologia, vol. 62, no. 11, pp. 2052-2065 . https://doi.org/10.1007/s00125-019-04974-yTest

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Endocrinology, Diabetes and Metabolism, Population, Autoimmunity, Mice, Transgenic, 030209 endocrinology & metabolism, Biology, Article, CD19, Immune tolerance, Islets of Langerhans, Mice, 03 medical and health sciences, 0302 clinical medicine, Mice, Inbred NOD, Anti-insulin B cells, Immune Tolerance, Internal Medicine, medicine, Animals, Humans, Insulin, education, Pancreas, NOD mice, CD20, B-Lymphocytes, education.field_of_study, Pancreatic islets, Antibodies, Monoclonal, Antigens, CD20, Flow Cytometry, 3. Good health, Type 1 diabetes, Diabetes Mellitus, Type 1, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Cancer research, Female, Immunotherapy, Anti-CD20 treatment

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f375246bc49d02b3e32401a2ce3599Test
https://doi.org/10.1007/s00125-019-04974-yTest

3

‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues

المؤلفون: Deepak Chatterjee, Mark A. Jarosinski, Balamurugan Dhayalan, Michael A. Weiss, Nischay K. Rege

المصدر: Diabetologia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2225e21e72676d79f8bb4bfabbac9bbTest
https://doi.org/10.1007/s00125-021-05422-6Test

4

Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1–SIRT1–PGC-1α

المؤلفون: Qi Guo, Shicheng Cao, Bo Chang, Xue-Jie Yi, Qiong-Li Yu, Si-Tong Xu

المصدر: Diabetologia. 63:2675-2688

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Models, Biological, Mice, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Sirtuin 1, Internal medicine, Coactivator, Internal Medicine, medicine, Animals, Muscle, Skeletal, Receptor, Adaptor Proteins, Signal Transducing, Adiponectin, biology, Chemistry, Myogenesis, Skeletal muscle, medicine.disease, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Mitochondrial biogenesis, biology.protein, Insulin Resistance, hormones, hormone substitutes, and hormone antagonists, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a341713b3ea16027e09e1426d0ae9927Test
https://doi.org/10.1007/s00125-020-05269-3Test

5

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway

المؤلفون: Dario F. De Jesus, A. M. James Shapiro, Giorgio Basile, Jun Shirakawa, Yasuo Terauchi, Tomoko Okuyama, Tatsuya Kin, Mayu Kyohara, Rohit N. Kulkarni, Kazuki Tajima, Yu Togashi

المصدر: Diabetologia

مصطلحات موضوعية: Male, medicine.medical_specialty, Mice, 129 Strain, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Article, Receptor, IGF Type 1, Gene Knockout Techniques, Mice, Downregulation and upregulation, Insulin-Secreting Cells, Internal medicine, Internal Medicine, medicine, Animals, Humans, Sorbitol, Beta (finance), Receptor, Cell Proliferation, biology, Chemistry, Insulin, Imidazoles, Drug Synergism, Receptor, Insulin, IRS2, Mice, Inbred C57BL, Insulin receptor, Endocrinology, Culture Media, Conditioned, Pyrazines, Insulin Receptor Substrate Proteins, biology.protein, Intercellular Signaling Peptides and Proteins, SGLT2 Inhibitor, Beta cell, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959f8d5e0daae0cb4b82752091f301feTest
https://doi.org/10.1007/s00125-019-05071-wTest

6

Phenotypic alterations in pancreatic lymph node stromal cells from human donors with type 1 diabetes and NOD mice

المؤلفون: Donna L. Farber, Remi J. Creusot, Jorge Postigo-Fernandez

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, T-Lymphocytes, Endocrinology, Diabetes and Metabolism, T cell, Gene Expression, Autoimmunity, 030209 endocrinology & metabolism, medicine.disease_cause, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Mice, Inbred NOD, Immune Tolerance, Internal Medicine, Lymph node stromal cell, medicine, Animals, Humans, Antigens, Pancreas, NOD mice, Immunosuppression Therapy, Antigen Presentation, MHC class II, biology, Peripheral tolerance, Dendritic Cells, Dendritic cell, Flow Cytometry, Tolerance induction, Diabetes Mellitus, Type 1, Phenotype, 030104 developmental biology, medicine.anatomical_structure, Immunology, biology.protein, Leukocyte Common Antigens, Female, Lymph Nodes, Stromal Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da94a71d203a5b68413c29e9be58785eTest
https://doi.org/10.1007/s00125-019-04984-wTest

7

Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes

المؤلفون: Yang Zhao, Qi Sun, Dan Weng, Junhao Liu, Yan Gao, Xi Xu, Shiming Wang, Jianfa Zhang, Xiao Yang, Wenhao Ge, Yunxia Yang

المصدر: Diabetologia. 62:2106-2117

مصطلحات موضوعية: Male, 0301 basic medicine, Magnetic Resonance Spectroscopy, Endocrinology, Diabetes and Metabolism, ATPase, Metabolite, Type 2 diabetes, Mice, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Adenine nucleotide, Homeostasis, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Nucleotides, Chemistry, Hydrogen-Ion Concentration, Middle Aged, Metformin, medicine.anatomical_structure, Liver, Hepatocyte, Female, medicine.drug, Adult, medicine.medical_specialty, Intracellular pH, 030209 endocrinology & metabolism, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, Animals, Humans, Adenine, Cell Membrane, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Kinetics, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Case-Control Studies, Hyperglycemia, Hepatocytes, biology.protein, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc6b30d187dbefb8c8ad54a81b9d2dTest
https://doi.org/10.1007/s00125-019-04971Test-1

8

Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes

المؤلفون: Reeta Rintamäki, Jorma Ilonen, Ahmad M. Gazali, Mikael Knip, Riitta Veijola, Tuure Kinnunen, Kirsti Näntö-Salonen, Anna-Mari Schroderus, Jussi Pihlajamäki, Jorma Toppari

المساهمون: Tampere University, Clinical Medicine, Department of Paediatrics, HUS Children and Adolescents, Children's Hospital, Research Programs Unit, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, Male, Endocrinology, Diabetes and Metabolism, LOCI, PROGRESSION, CHILDREN, Autoimmunity, SUSCEPTIBILITY, medicine.disease_cause, 0302 clinical medicine, Immunophenotyping, Mucosal immunity, 3123 Gynaecology and paediatrics, Cells, Cultured, RISK, 318 Medical biotechnology, medicine.diagnostic_test, biology, CORRELATE, Flow Cytometry, medicine.anatomical_structure, Type 1 diabetes, Female, Human, Adult, T cell, CD3, T cells, MAIT cells, Mucosal associated invariant T cell, 3121 Internal medicine, Mucosal-Associated Invariant T Cells, Article, Flow cytometry, 03 medical and health sciences, Diabetes mellitus, Internal Medicine, medicine, Humans, business.industry, medicine.disease, TRENDS, Immunity, Innate, MICROBIOTA COMPOSITION, 030104 developmental biology, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 3121 General medicine, internal medicine and other clinical medicine, Immunology, biology.protein, Natural Killer T-Cells, business, 030215 immunology

وصف الملف: fulltext; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6eed56f74cec1b6a065454ac09a925Test
https://pubmed.ncbi.nlm.nih.gov/32880687Test

9

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients

المؤلفون: Robert Hilbrands, Zhidong Ling, Frans Gorus, Bart Keymeulen, Bart Van Der Auwera, Pieter Gillard, Else M. Balke, DaHae Lee, Ursule Van de Velde, Bart O. Roep, Simke Demeester, Daniel Pipeleers

المساهمون: Pathology/molecular and cellular medicine, Faculty of Medicine and Pharmacy, Diabetes Pathology & Therapy, Clinical Biology, Diabetes Clinic, Public Health Sciences, Vriendenkring VUB

المصدر: Diabetologia, 61(7), 1623-1632
Diabetologia

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Multivariate analysis, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Islets of Langerhans Transplantation, HLA-A24 Antigen, Zinc transporter 8, Gastroenterology, 0302 clinical medicine, Risk Factors, Insulin-Secreting Cells, Insulin, Medicine, Body mass index, Clinical Trials as Topic, geography.geographical_feature_category, SLC30A8, biology, Immunosuppression, Middle Aged, Allografts, Islet, 3. Good health, Treatment Outcome, Cohort, Female, medicine.medical_specialty, 030209 endocrinology & metabolism, HLAclass I, Human islet transplantation, 03 medical and health sciences, Internal medicine, Internal Medicine, Humans, Hypoglycemic Agents, Allele, Retrospective Studies, geography, Polymorphism, Genetic, business.industry, HLA class I, Recovery of Function, Transplantation, Diabetes Mellitus, Type 1, 030104 developmental biology, Genetics of type 1 diabetes, biology.protein, business, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da83fa24dcd777c2e792636bb50b32dcTest
https://doi.org/10.1007/s00125-018-4609-zTest

10

Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes

المؤلفون: Andrew D. Paterson, Shelley B. Bull, Hillary A. Keenan, Delnaz Roshandel, Rose Gubitosi-Klug, Ronald Klein, Barbara E.K. Klein, Angelo J. Canty, Michael N. Weedon, George L. King, Janet K. Snell-Bergeon, Marcus G. Pezzolesi, Tina Costacou, Richard A. Oram, Trevor J. Orchard, David M. Maahs

المصدر: Diabetologia

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Genome-wide association study, medicine.medical_specialty, Adolescent, Genotype, Endocrinology, Diabetes and Metabolism, Locus (genetics), Single-nucleotide polymorphism, Major histocompatibility complex, Polymorphism, Single Nucleotide, Article, Young Adult, 03 medical and health sciences, Gene Frequency, Internal medicine, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Alleles, Type 1 diabetes, C-Peptide, biology, Insulin-secreting cells, Histocompatibility Antigens Class I, medicine.disease, Single nucleotide polymorphism, 3. Good health, Minor allele frequency, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, Chromosomes, Human, Pair 1, biology.protein, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14180d6dbba4f52f5e1945969049c8a7Test
https://doi.org/10.1007/s00125-018-4555-9Test

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