المؤلفون: Matthew A. Cerny, A. David Rodrigues, Brian Rago, Sarah Lazzaro, Ragu Ramanathan, Chester Costales, Mikko Neuvonen, Aleksi Tornio, Manthena V.S. Varma, Mark A. West, Sumathy Mathialagan, Päivi Hirvensalo, Mikko Niemi

المساهمون: HUSLAB, Department of Clinical Pharmacology, Department of Diagnostics and Therapeutics, University of Helsinki, Helsinki University Hospital Area, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Medicum

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Male, Pharmacogenomic Variants, 030226 pharmacology & pharmacy, 0302 clinical medicine, Tandem Mass Spectrometry, Genotype, ANION TRANSPORTING POLYPEPTIDE, CYNOMOLGUS MONKEYS, Pharmacology (medical), DRUG-INTERACTION, Oligonucleotide Array Sequence Analysis, BILE-ACIDS, biology, Chemistry, Liver-Specific Organic Anion Transporter 1, Articles, Healthy Volunteers, 3. Good health, Organic anion-transporting polypeptide, POLYMORPHISM MARKEDLY AFFECTS, Phenotype, Liver, 317 Pharmacy, 030220 oncology & carcinogenesis, ENDOGENOUS BIOMARKERS, Biomarker (medicine), Female, Glucuronide, Adult, medicine.medical_specialty, PLASMA-CONCENTRATIONS, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Young Adult, Glucuronides, Glycochenodeoxycholic Acid, Internal medicine, SLCO1B1 POLYMORPHISM, medicine, Humans, HAPLOTYPE RECONSTRUCTION, Pharmacology, Receiver operating characteristic, Research, Haplotype, GENOME-WIDE, In vitro, Metabolic Detoxication, Phase II, Endocrinology, HEK293 Cells, biology.protein, SLCO1B1, Biomarkers, Chromatography, Liquid, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bbecde5bac675897f44df4cf2a0148Test
https://pubmed.ncbi.nlm.nih.gov/32961594Test

المؤلفون: Paul W. Stewart, E. Tsakalozou, Kim L. R. Brouwer, C. K. Johnston, Mary F. Paine, Wei Jia, Arlene S. Bridges, Brian C. Ferslew, A. S. Barritt

المصدر: Clinical pharmacology and therapeutics. 97(4)

مصطلحات موضوعية: Adult, Liver Cirrhosis, Male, medicine.medical_specialty, medicine.drug_class, Cmax, digestive system, Article, Bile Acids and Salts, Cohort Studies, Insulin resistance, Pharmacokinetics, Non-alcoholic Fatty Liver Disease, Internal medicine, medicine, Humans, Pharmacology (medical), Pharmacology, Morphine Derivatives, Bile acid, Chemistry, Middle Aged, medicine.disease, Analgesics, Opioid, Endocrinology, Biochemistry, Liver, Area Under Curve, Toxicity, Morphine, Female, Efflux, Insulin Resistance, Glucuronide, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddf69bdc95ade788e6d487aa33fe61aTest
https://pubmed.ncbi.nlm.nih.gov/25669174Test

المؤلفون: Estelle Simen, Claude Dubray, Isabelle Papet, E Schneider, Pierre Schoeffler, Gisèle Pickering, Bruno Pereira, Estelle Pujos-Guillot

المساهمون: CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), We thank all persons who collaborated in the study, especially Francoise Glomot, for glutathione measurements, and Bernard Lyan, for quantification of APAP metabolites. This study was supported by a clinical research allowance from the French Ministry of Health., Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université

المصدر: Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2011, 90 (5), pp.707-711. ⟨10.1038/clpt.2011.176⟩

مصطلحات موضوعية: Male, medicine.medical_specialty, Aging, Antioxidant, [SDV]Life Sciences [q-bio], Urinary system, medicine.medical_treatment, Oxidative phosphorylation, Pharmacology, pharmacology and pharmacy, surgery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, detoxification, 030304 developmental biology, Acetaminophen, Aged, 0303 health sciences, Analysis of Variance, hepatic metabolism, acetaminophen (APAP), business.industry, digestive, oral, and skin physiology, Age Factors, Glutathione, Metabolism, Analgesics, Non-Narcotic, Middle Aged, 3. Good health, Surgery, chemistry, Liver, 030220 oncology & carcinogenesis, Surgical Procedures, Operative, Female, business, Glucuronide, Oxidation-Reduction, Drug metabolism, medicine.drug, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3caa2c7e2911cb26fd42cf5e17f131Test
https://pubmed.ncbi.nlm.nih.gov/21975347Test

المؤلفون: Janne T. Backman, Tiina Karonen, Pertti J. Neuvonen, Jouko Laitila, Anne M. Filppula, Mikko Niemi

المصدر: Clinical pharmacology and therapeutics. 88(2)

مصطلحات موضوعية: Adult, Cyclopropanes, Male, medicine.medical_specialty, Genotype, Pharmacology, Acetates, Sulfides, Placebo, Mass Spectrometry, Cytochrome P-450 CYP2C8, Young Adult, Glucuronides, Pharmacokinetics, immune system diseases, Internal medicine, medicine, Gemfibrozil, Humans, Pharmacology (medical), Drug Interactions, Anti-Asthmatic Agents, CYP2C8, Montelukast, Biotransformation, Hypolipidemic Agents, Cross-Over Studies, Chemistry, DNA, Crossover study, respiratory tract diseases, Endocrinology, Area Under Curve, Microsome, Microsomes, Liver, Quinolines, Leukotriene Antagonists, Female, Aryl Hydrocarbon Hydroxylases, Glucuronide, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d5e61baa18ef15998ce8a3d93ec583Test
https://pubmed.ncbi.nlm.nih.gov/20592724Test

المؤلفون: James M. Boyett, Federico Innocenti, Deqing Pei, Friedl H. Pantle-Fisher, Jacqueline Ramírez, Edwin H. Cook, Michael B. Sawyer, Mark J. Ratain, Judith A. Badner, Soma Das, Cheng Cheng, Constance Wright

المصدر: Clinical pharmacology and therapeutics. 73(6)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Glucuronosyltransferase, Genotype, Glucuronidation, Black People, Pharmacology, White People, chemistry.chemical_compound, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Biotransformation, Aged, Aged, 80 and over, Morphine Derivatives, biology, Morphine, business.industry, Analgesia, Patient-Controlled, Middle Aged, Uridine, UGT2B7, Analgesics, Opioid, Uridine diphosphate, Endocrinology, Phenotype, chemistry, biology.protein, Female, Indicators and Reagents, Glucuronide, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c97ffa28e374eee84c9950cf1382ea4Test
https://pubmed.ncbi.nlm.nih.gov/12811366Test

المؤلفون: Cheri E. Klein, Helen Kastrissios, Henry C. Pitot, Mark J. Ratain, Jeff A. Sloan, Joel M. Reid, Pamela J. Atherton, Elora Gupta

المصدر: Clinical pharmacology and therapeutics. 72(6)

مصطلحات موضوعية: Adult, Male, Metabolite, Population, SN-38, Glucuronates, Pharmacology, Irinotecan, Kidney Function Tests, chemistry.chemical_compound, Pharmacokinetics, Liver Function Tests, Predictive Value of Tests, medicine, Humans, Pharmacology (medical), education, Infusions, Intravenous, Active metabolite, education.field_of_study, Dose-Response Relationship, Drug, Chemistry, Reproducibility of Results, Bilirubin, Alkaline Phosphatase, Antineoplastic Agents, Phytogenic, Dose–response relationship, Area Under Curve, Creatinine, Camptothecin, Female, Drug Monitoring, Glucuronide, Oxidoreductases, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37352a4e11c0e7a7cfe32632de2038bTest
https://pubmed.ncbi.nlm.nih.gov/12496745Test

المؤلفون: Ralph E. Kauffman, Herbert G. Uy, M.K. Aravind, Mary Lieh-Lai

المصدر: Clinical pharmacology and therapeutics. 65(4)

مصطلحات موضوعية: Male, Adolescent, Glucuronidation, Pharmacology, Pharmacokinetics, Double-Blind Method, medicine, Humans, Pharmacology (medical), Tolmetin, Child, Chromatography, High Pressure Liquid, Volume of distribution, Pain, Postoperative, Morphine, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Stereoisomerism, body regions, Chiral column chromatography, Ketorolac, Analgesics, Opioid, Child, Preschool, Injections, Intravenous, Stereoselectivity, Female, Enantiomer, Glucuronide, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db5b220dc8d8e80dcfd7beb13c9da38Test
https://pubmed.ncbi.nlm.nih.gov/10223774Test

المؤلفون: Chiung‐Yao Tseng, Ming Derg Lai, Jin-ding Huang, Ming‐Liang Lai, Su-Lan Wang

المصدر: Clinical pharmacology and therapeutics. 60(2)

مصطلحات موضوعية: Adult, Male, CYP2D6, Genotype, Urinary system, Codeine Phosphate, Pharmacology, Polymerase Chain Reaction, Pharmacokinetics, Asian People, Oral administration, Reference Values, medicine, Humans, Pharmacology (medical), Chromatography, High Pressure Liquid, Analysis of Variance, Morphine, Chemistry, Codeine, Cytochrome P-450 CYP2D6, Glucuronide, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52cf95bcbb5ca91e8f80c6e3e764f89Test
https://pubmed.ncbi.nlm.nih.gov/8823235Test

المؤلفون: Frans M. Belpaire, Marc G. Bogaert, Romain Lefebvre, Hans Vanhoe, Martine E. Laethem

المصدر: Clinical pharmacology and therapeutics. 57(4)

مصطلحات موضوعية: Pharmacology, Adult, Male, Chromatography, Time Factors, Chemistry, Oxprenolol, Glucuronates, Stereoisomerism, Urine, Pharmacokinetics, Free fraction, Oral administration, Reference Values, Renal physiology, medicine, Humans, Pharmacology (medical), Stereoselectivity, cardiovascular diseases, Glucuronide, circulatory and respiratory physiology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798b4f95143d3ef375b0d3b9f9107849Test
https://pubmed.ncbi.nlm.nih.gov/7712670Test

المؤلفون: Leslie Z. Benet, Antony F. McDonagh, Parnian Zia-Amirhosseini, Hildegard Spahn-Langguth, Joseph C. Ojingwa

المصدر: Clinical pharmacology and therapeutics. 55(1)

مصطلحات موضوعية: Pharmacology, Adult, Male, Metabolite, Metabolism, Blood Proteins, Blood proteins, Drug Administration Schedule, chemistry.chemical_compound, chemistry, Pharmacokinetics, Oral administration, In vivo, medicine, Tolmetin, Humans, Pharmacology (medical), Female, Glucuronide, medicine.drug, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52d9e4c333e19b1cf72b245b93c361cTest
https://pubmed.ncbi.nlm.nih.gov/8299313Test