Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention
| العنوان: | Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention |
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| المؤلفون: | Javad Sharifi-Rad, Muhammad Naeem Shahwani, Khushbukhat Khan, Shahid Raza, Bahare Salehi, Amna Rasheed, Asma Irshad, Cristina Quispe, Hafiz Ansar Rasul Suleria, Haleema Sadia, Natália Cruz-Martins, Zeeshan Javed |
| المساهمون: | Instituto de Investigação e Inovação em Saúde |
| المصدر: | Cancer Cell International Cancer Cell International, Vol 21, Iss 1, Pp 1-13 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Curcumin, Review, lcsh:RC254-282, 03 medical and health sciences, Prostate cancer, chemistry.chemical_compound, Therapeutic approach, 0302 clinical medicine, microRNA, Genetics, Medicine, lcsh:QH573-671, 030304 developmental biology, 0303 health sciences, Nanoformulations, lcsh:Cytology, business.industry, Cancer, Diagnostic markers, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Androgen receptor, MicroRNAs, Oncology, chemistry, 030220 oncology & carcinogenesis, Drug delivery, Cancer research, Androgen receptor signaling, business, Hormone |
| الوصف: | Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in recent decades are focused on investigating the anti-tumor effects of natural compounds in PC. Curcumin is widely recognized and now of huge prestige for its anti-proliferative abilities in different types of cancer. However, its limited solubility, compatibility, and instability in the aqueous phase are major hurdles when administering. Nanoformulations have proven to be an excellent drug delivery system for various drugs and can be used as potential delivery platforms for curcumin in PC. In this review, a shed light is given on the miRNAs-mediated regulation of androgen receptor (AR) signaling and miRNA-curcumin interplay in PC, as well as on curcumin-based nanoformulations that can be used as possible therapeutic solutions for PC. |
| وصف الملف: | application/pdf |
| تدمد: | 1475-2867 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01704e8e01227ec51d438692303be15Test https://doi.org/10.1186/s12935-021-01777-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b01704e8e01227ec51d438692303be15 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752867 |
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