Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV
| العنوان: | Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV |
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| المؤلفون: | Simon B. Ascher, Amanda B. Spence, Chirag R. Parikh, Deborah R. Gustafson, Vasantha Jotwani, Carl Grunfeld, Mardge H. Cohen, Michelle M. Estrella, Michael G. Shlipak, Joachim H. Ix, Rebecca Scherzer, Derek K. Ng, Kimberly A. Spaulding, Anjali Sharma, Judy K. Shigenaga, Anthony N. Muiru |
| المصدر: | BMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021) BMC nephrology, vol 22, iss 1 BMC Nephrology |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Nephrology, medicine.medical_specialty, Kidney Disease, Tamm–Horsfall protein, Clinical Sciences, Population, Renal and urogenital, Renal function, HIV Infections, Urine biomarkers HIV CKD, Risk Factors, Clinical Research, Internal medicine, medicine, Humans, Renal Insufficiency, Hepatitis A Virus Cellular Receptor 1, Renal Insufficiency, Chronic, Chronic, Risk factor, education, Glycated Hemoglobin, education.field_of_study, biology, business.industry, Research, Prevention, Middle Aged, Urology & Nephrology, medicine.disease, Diseases of the genitourinary system. Urology, Kidney Tubules, Infectious Diseases, Good Health and Well Being, Anti-Retroviral Agents, biology.protein, Albuminuria, HIV/AIDS, Biomarker (medicine), Female, RC870-923, medicine.symptom, business, Biomarkers, Kidney disease |
| الوصف: | Background Novel urine biomarkers have enabled the characterization of kidney tubular dysfunction and injury among persons living with HIV, a population at an increased risk of kidney disease. Even though several urine biomarkers predict progressive kidney function decline, antiretroviral toxicity, and mortality in the setting of HIV infection, the relationships among the risk factors for chronic kidney disease (CKD) and urine biomarkers are unclear. Methods We assessed traditional and infection-related CKD risk factors and measured 14 urine biomarkers at baseline and at follow-up among women living with HIV in the Women’s Interagency Health Study (WIHS). We then used simultaneously adjusted multivariable linear regression models to evaluate the associations of CKD risk factors with longitudinal changes in biomarker levels. Results Of the 647 women living with HIV in this analysis, the majority (67%) were Black, the median age was 45 years and median follow-up time was 2.5 years. Each traditional and infection-related CKD risk factor was associated with a unique set of changes in urine biomarkers. For example, baseline hemoglobin a1c was associated with worse tubular injury (higher interleukin [IL]-18), proximal tubular reabsorptive dysfunction (higher α1-microglobulin), tubular reserve (lower uromodulin) and immune response to injury (higher chitinase-3-like protein-1 [YKL-40]). Furthermore, increasing hemoglobin a1c at follow-up was associated with further worsening of tubular injury (higher kidney injury molecule-1 [KIM-1] and IL-18), as well as higher YKL-40. HCV co-infection was associated with worsening proximal tubular reabsorptive dysfunction (higher β2-microglobulin [β2m]), and higher YKL-40, whereas HIV viremia was associated with worsening markers of tubular and glomerular injury (higher KIM-1 and albuminuria, respectively). Conclusions CKD risk factors are associated with unique patterns of biomarker changes among women living with HIV, suggesting that serial measurements of multiple biomarkers may help in detecting and monitoring kidney disease in this setting. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-2369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c3629c2e8fae5047ada4020e2cde1cTest https://doi.org/10.1186/s12882-021-02508-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....96c3629c2e8fae5047ada4020e2cde1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712369 |
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