Impact of a Genetic Polymorphism of the Interleukin-1 Receptor Antagonist on Technique Survival in Peritoneal Dialysis Patients
| العنوان: | Impact of a Genetic Polymorphism of the Interleukin-1 Receptor Antagonist on Technique Survival in Peritoneal Dialysis Patients |
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| المؤلفون: | Kozue Fujimura, Naoko Okayama, Yuji Hinoda, Kimio Takai, Koichi Uchiyama, Katsusuke Naito, Masahiro Tsuchida |
| المصدر: | Blood Purification. 23:450-458 |
| بيانات النشر: | S. Karger AG, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Sialoglycoproteins, medicine.medical_treatment, Peritonitis, Peritoneal dialysis, Interleukin 1 Receptor Antagonist Gene, Gene Frequency, Predictive Value of Tests, Polymorphism (computer science), medicine, Humans, Renal Insufficiency, Allele, Gene, Alleles, Polymorphism, Genetic, business.industry, Interleukin, Hematology, General Medicine, Middle Aged, Interleukin 1 Receptor Antagonist Protein, Interleukin 1 receptor antagonist, Cardiovascular Diseases, Nephrology, Immunology, Female, Dialisis peritoneal, business, Peritoneal Dialysis |
| الوصف: | Background/Aims: There is a clear association between one allele of the interleukin-1 receptor-antagonist gene (IL-1RN) and inflammatory diseases in which IL-1 is implicated. We evaluated patient survival and technique survival of peritoneal dialysis (PD) patients, while analyzing independent risk factors, in a PD program. We also tested the association between IL-1RN polymorphism, patient survival and technique survival. Methods: We retrospectively evaluated 129 Japanese CAPD patients undergoing initial treatment in eight centers in Japan. Using PCR, IL-1RN genotype and allele frequencies were determined, and clinical and biochemical variables were recorded at the start of PD. The relation of patient survival or technique survival with IL-1RN polymorphism and those variables was analyzed with a multivariate Cox’s proportional-hazard model. Results: The frequencies of IL-1RN*1/IL-1RN*1 and IL-1RN*1/IL-1RN*2 genotypes were 84.5 and 15.5%, respectively. Median patient survival was 37.0 months, and overall patient survival was 92.8 and 87.9% at 2 and 5 years, respectively. Age, cardiovascular disease and serum albumin were found to be independent predictors of patient survival. Median technique survival was 32 months. PD failure occurred in 37 patients, with technique survival rates of 92.0 and 72.7% at 2 and 5 years, respectively. Serum albumin, peritonitis and the presence of the IL-1RN*2 genotype were found to be independent predictors of technique survival. Conclusion: Serum albumin was the strongest predictive factor for mortality and technique failure in PD. Technique failure was also affected by IL-1RN polymorphism in this patient population. |
| تدمد: | 1421-9735 0253-5068 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4353a96671c9113c70a174759963aca6Test https://doi.org/10.1159/000088988Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4353a96671c9113c70a174759963aca6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219735 02535068 |
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