Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study
| العنوان: | Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study |
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| المؤلفون: | Elena H. Martinez-Lapiscina, Bernhard Hemmer, Teresa C. Frohman, Pablo Villoslada, Raed Behbehani, Alexander U. Brandt, Abdullah Abu Al-Hassan, Benjamin Knier, Omar Akhand, Hanna Zimmermann, Lisanne J. Balk, Hong Jiang, Letizia Leocani, Shiv Saidha, Athina Papadopoulou, Steven L. Galetta, Rachel Nolan-Kenney, Friedemann Paul, Elliot M. Frohman, Thomas Korn, Axel Petzold, Mengling Liu, Joachim Havla, Marco Pisa, Peter A. Calabresi, Laura J. Balcer |
| المساهمون: | Ophthalmology, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Mental Health, APH - Methodology, Neurology, Nolan-Kenney, R. C., Liu, M., Akhand, O., Calabresi, P. A., Paul, F., Petzold, A., Balk, L., Brandt, A. U., Martinez-Lapiscina, E. H., Saidha, S., Villoslada, P., Al-Hassan, A. A., Behbehani, R., Frohman, E. M., Frohman, T., Havla, J., Hemmer, B., Jiang, H., Knier, B., Korn, T., Leocani, L., Papadopoulou, A., Pisa, M., Zimmermann, H., Galetta, S. L., Balcer, L. J. |
| المصدر: | Nolan-Kenney, R C, Liu, M, Akhand, O, Calabresi, P A, Paul, F, Petzold, A, Balk, L, Brandt, A U, Martínez-Lapiscina, E H, Saidha, S, Villoslada, P, Al-Hassan, A A, Behbehani, R, Frohman, E M, Frohman, T, Havla, J, Hemmer, B, Jiang, H, Knier, B, Korn, T, Leocani, L, Papadopoulou, A, Pisa, M, Zimmermann, H, Galetta, S L, Balcer, L J & on behalf of the International Multiple Sclerosis Visual System Consortium 2019, ' Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study ', Annals of Neurology, vol. 85, no. 5, pp. 618-629 . https://doi.org/10.1002/ana.25462Test Annals of Neurology, 85(5), 618-629. John Wiley and Sons Inc. |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Retinal Ganglion Cells, 0301 basic medicine, medicine.medical_specialty, Internationality, Multiple Sclerosis, Adolescent, genetic structures, Visual Acuity, Nerve fiber layer, Retinal Ganglion Cell, Nerve fiber, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, Multiple Sclerosi, medicine, Humans, Optic neuritis, Retinal thinning, Aged, business.industry, Multiple sclerosis, Optic Nerve, Middle Aged, medicine.disease, Inner plexiform layer, eye diseases, Ganglion, 030104 developmental biology, medicine.anatomical_structure, Neurology, Retinal Neuron, Optic nerve, Female, sense organs, Neurology (clinical), Cohort Studie, business, Tomography, Optical Coherence, 030217 neurology & neurosurgery, Human, Retinal Neurons |
| الوصف: | Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High- and low-contrast acuity were also collected in a subset of participants. Presence of an optic nerve lesion for this study was defined as history of acute unilateral optic neuritis. Results Among patients (n = 1,530), receiver operating characteristic curve analysis demonstrated an optimal peripapillary retinal nerve fiber layer intereye difference threshold of 5μm and ganglion cell + inner plexiform layer threshold of 4μm for identifying unilateral optic neuritis (n = 477). Greater intereye differences in acuities were associated with greater intereye retinal layer thickness differences (p ≤ 0.001). Interpretation Intereye differences of 5μm for retinal nerve fiber layer and 4μm for macular ganglion cell + inner plexiform layer are robust thresholds for identifying unilateral optic nerve lesions. These thresholds may be useful in establishing the presence of asymptomatic and symptomatic optic nerve lesions in multiple sclerosis and could be useful in a new version of the diagnostic criteria. Our findings lend further validation for utilizing the visual system in a multiple sclerosis clinical trial setting. Ann Neurol 2019;85:618-629. |
| تدمد: | 1531-8249 0364-5134 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83666a57002114db78044946b0b46211Test https://doi.org/10.1002/ana.25462Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....83666a57002114db78044946b0b46211 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318249 03645134 |
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