Venetoclax plus azacitidine and donor lymphocyte infusion in treating acute myeloid leukemia patients who relapse after allogeneic hematopoietic stem cell transplantation
| العنوان: | Venetoclax plus azacitidine and donor lymphocyte infusion in treating acute myeloid leukemia patients who relapse after allogeneic hematopoietic stem cell transplantation |
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| المؤلفون: | Mei Zhao, Min Liu, Peng Zhao, Yi Huang, Shisi Huang, Shuangshuang Wen, Ying Chen, Bo Deng, Dan Ma, Yan Zhang, Ming Ni, Yan Li, Yun Zhan, Yanju Li, Xiao Chai, Fengqi Zhang, Qian Kang, Jishi Wang, Qin Fang |
| المصدر: | Annals of Hematology |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, medicine.medical_treatment, Azacitidine, Hematopoietic stem cell transplantation, Allo-HSCT, Gene mutation, Donor lymphocyte infusion, Venetoclax, Young Adult, chemistry.chemical_compound, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Transplantation, Homologous, Adverse effect, Relapsed acute myeloid leukemia, Sulfonamides, Azacytidine, Hematology, business.industry, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, General Medicine, Middle Aged, Bridged Bicyclo Compounds, Heterocyclic, Leukemia, Myeloid, Acute, Treatment Outcome, chemistry, Lymphocyte Transfusion, Female, Original Article, Neoplasm Recurrence, Local, business, Follow-Up Studies, medicine.drug |
| الوصف: | This study aimed to evaluate the efficacy and safety of venetoclax plus azacitidine and donor lymphocyte infusion (DLI) in treating patients with relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-six AML patients who relapsed after allo-HSCT were enrolled and treated with venetoclax plus azacitidine and DLI. Complete remission with incomplete recovery (CRi), partial remission (PR), and objective remission rate (ORR) were assessed, and then event-free survival (EFS) and overall survival (OS) were evaluated. Besides, adverse events were documented. Additionally, whole exome sequencing was performed in bone marrow samples. The CRi, PR, and ORR rates were 26.9%, 34.6%, and 61.5%, respectively. The median time of EFS and OS was 120 (95% CI: 71–610) days and 284.5 (95% CI: 81–610) days, respectively. The most common adverse events were hematologic system adverse events including agranulocytosis, anemia, and thrombocytopenia, while the adverse events of other systems were relatively less and milder. In addition, no serious adverse events existed. Of note, there were 6 (23.1%) patients who developed GVHD. As for gene mutation, 49 mutated genes were found, which were categorized as first-, second-, and third-class mutations, and then further analysis revealed that the first-class mutations were not correlated with EFS or OS. Additionally, the most frequent mutated genes were FLT3, CEBPA, DNMT3A, KIT, KRAS, and NRAS. Venetoclax plus azacitidine and DLI is efficient and tolerant in treating patients with relapsed AML after allo-HSCT, implying this combined therapy as a potential treatment option in the studied patients. Supplementary Information The online version contains supplementary material available at 10.1007/s00277-021-04674-x. |
| تدمد: | 1432-0584 0939-5555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481077f6ee6f09546256ded2f5d5b0c3Test https://doi.org/10.1007/s00277-021-04674-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....481077f6ee6f09546256ded2f5d5b0c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320584 09395555 |
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