دورية أكاديمية
Natural antibody--complement dependent neutralization of bovine herpesvirus 4 by human serum
| العنوان: | Natural antibody--complement dependent neutralization of bovine herpesvirus 4 by human serum |
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| المؤلفون: | Machiels, Bénédicte, Gillet, Laurent, Brito, Sieberth Do Nascimento, Drion, Pierre, Delforge, Cédric, Nizet, Yannick, Gianello, Pierre, Bona, Christophe, Costes, Bérénice, Markine-Goriaynoff, Nicolas, Vanderplasschen, Alain |
| المصدر: | Microbes and Infection, 9 (14-15), 1530-1537 (2007) |
| بيانات النشر: | Elsevier Science, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Bovine herpesvirus 4, Innate anti-viral immunity, Virus neutralization, Natural antibodies, Life sciences, Veterinary medicine & animal health, Sciences du vivant, Médecine vétérinaire & santé animale |
| الوصف: | In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoHV-4 could lead to human infections. In the present study, we investigate the sensitivity of BoHV-4 to neutralization by naïve human sera in order to determine if humans exhibit innate anti-viral activities against this virus. Our results demonstrate that human sera from naïve individuals, in contrast to the sera of naïve subjects from various animal species, neutralize BoHV-4 efficiently. A series of complementary experiments were performed to unravel the mechanism(s) of this neutralization. The data obtained in this study demonstrates that human serum neutralizes BoHV-4 in a complement dependent manner activated by natural antibodies raised against the Galalpha1-3Galbeta1-4GlcNAc-R epitope expressed by bovine cells |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VPN-4PJCYK0-2&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=1f7db6185dc6f13484b1d3019ea5ad3eTest; urn:issn:1286-4579 |
| DOI: | 10.1016/j.micinf.2007.08.007 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/18041Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.18041 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1016/j.micinf.2007.08.007 |
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